Nanodiamonds Inhibit Cancer Cell Migration by Strengthening Cell Adhesion: Implications for Cancer Treatment
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| Název: | Nanodiamonds Inhibit Cancer Cell Migration by Strengthening Cell Adhesion: Implications for Cancer Treatment |
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| Autoři: | Qingyue Guo, Lei Li, Guanyue Gao, Runze Liu, Yasuaki Einaga, Jinfang Zhi |
| Zdroj: | ACS Applied Materials & Interfaces. 13:9620-9629 |
| Informace o vydavateli: | American Chemical Society (ACS), 2021. |
| Rok vydání: | 2021 |
| Témata: | Male, Epithelial-Mesenchymal Transition, Chemical Sciences not elsewhere classified, Immunology, 02 engineering and technology, decrease tumor metastasis, Strengthening Cell Adhesion, 01 natural sciences, Nanodiamonds, murine B 16 melanoma cells, Mice, tumor cell migration, Cell Movement, cND, Cell Line, Tumor, Neoplasms, Genetics, Cell Adhesion, Animals, Humans, Neoplasm Metastasis, Molecular Biology, Nanodiamonds Inhibit Cancer Cell Mi, Cancer, Pharmacology, F-actin staining experiments, EMT, cell adhesion, cancer cell migration, Cell Biology, Cancer Treatment Nanodiamonds, growth factor β, TGF, Actins, 0104 chemical sciences, 3. Good health, Actin Cytoskeleton, protein expression level, Female, ND, 0210 nano-technology, Physical Sciences not elsewhere classified, Developmental Biology, Biological Sciences not elsewhere classified |
| Popis: | Nanodiamonds (NDs) are a type of biocompatible nanomaterial with easily modified surfaces and are considered as promising candidates in biomedicine. In this work, the inhibition of tumor cell migration by carboxylated nanodiamonds (cNDs) was investigated. AFM-based single cell adhesion and F-actin staining experiments demonstrated that cNDs treatment could enhance cell adhesion and impair assembly of the cytoskeleton. The mechanism analysis of the regulatory protein expression level also proved that cNDs could inhibit the migration of Hela cells by preventing the epithelial-mesenchymal transition (EMT) process through the transforming growth factor β (TGF-β) signaling pathway. The in vivo pulmonary metastasis model also showed that cNDs effectively reduced the metastasis of murine B16 melanoma cells. In summary, cNDs have been demonstrated to inhibit cancer cell migration in vitro and decrease tumor metastasis in vivo. Therefore, cNDs might have potential utility for specific cancer treatment. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.0c21332 |
| DOI: | 10.1021/acsami.0c21332.s001 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/33595291 https://pubmed.ncbi.nlm.nih.gov/33595291/ https://europepmc.org/article/MED/33595291 https://www.ncbi.nlm.nih.gov/pubmed/33595291 https://keio.pure.elsevier.com/en/publications/nanodiamonds-inhibit-cancer-cell-migration-by-strengthening-cell- https://pubs.acs.org/doi/10.1021/acsami.0c21332 |
| Rights: | STM Policy #29 CC BY NC |
| Přístupové číslo: | edsair.doi.dedup.....9635665d19a8fc4c5aed173c749cbf56 |
| Databáze: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | Nanodiamonds (NDs) are a type of biocompatible nanomaterial with easily modified surfaces and are considered as promising candidates in biomedicine. In this work, the inhibition of tumor cell migration by carboxylated nanodiamonds (cNDs) was investigated. AFM-based single cell adhesion and F-actin staining experiments demonstrated that cNDs treatment could enhance cell adhesion and impair assembly of the cytoskeleton. The mechanism analysis of the regulatory protein expression level also proved that cNDs could inhibit the migration of Hela cells by preventing the epithelial-mesenchymal transition (EMT) process through the transforming growth factor β (TGF-β) signaling pathway. The in vivo pulmonary metastasis model also showed that cNDs effectively reduced the metastasis of murine B16 melanoma cells. In summary, cNDs have been demonstrated to inhibit cancer cell migration in vitro and decrease tumor metastasis in vivo. Therefore, cNDs might have potential utility for specific cancer treatment. |
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| ISSN: | 19448252 19448244 |
| DOI: | 10.1021/acsami.0c21332 |