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Identifying neurological comorbidities in obstructive sleep apnea patients through polysomnography

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Title: Identifying neurological comorbidities in obstructive sleep apnea patients through polysomnography
Authors: Lothar Burghaus, Lisa Piano, Gereon R. Fink, Lennart Knaack
Source: Sleep Breath
Sleep and breathing 25, 1555-1557 (2021). doi:10.1007/s11325-020-02231-w
Publisher Information: Springer Science and Business Media LLC, 2020.
Publication Year: 2020
Subject Terms: Sleep Apnea, Obstructive, Sleep Breathing Physiology and Disorders • Letter to the Editors, Polysomnography, Comorbidity, Middle Aged, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Neurology, Pediatrics, Aged [MeSH], Pneumology/Respiratory System, Humans [MeSH], Sleep Apnea, Obstructive/epidemiology [MeSH], Dentistry, Nervous System Diseases/epidemiology [MeSH], Middle Aged [MeSH], Polysomnography [MeSH], Sleep Apnea, Obstructive/physiopathology [MeSH], Otorhinolaryngology, Comorbidity [MeSH], Internal Medicine, Nervous System Diseases/diagnosis [MeSH], Humans, Nervous System Diseases, 0305 other medical science, Aged
Description: Purpose!#!Adaptive servo-ventilation (ASV) is a therapy designed for patients with central sleep apnea (CSA) and Cheyne Stokes respiration. The aim of this study was to find predictors of ASV usage in patients with CSA in a routine sleep clinic cohort.!##!Methods!#!In this retrospective study, consecutive patients in whom ASV therapy was initiated at the University Hospital Regensburg between 2011 and 2015, were analyzed. Analysis included polysomnographies of diagnostic and ASV initiation nights, a phone questionnaire on ASV usage, readout of the ASV device 1 month after initiation ('early ASV usage,' 1 month after ASV initiation), and the readout of the last month before a reappointment date set in 2015 ('late ASV usage,' median 17 months after ASV initiation).!##!Results!#!In 69 consecutive patients, the mean early and late ASV usage per night was 4.8 ± 2.5 h and 4.1 ± 3.0 h, respectively. Seventeen months after initiation, 57% of patients used the device ≥ 4 h per night, and of those 91% reported a subjective benefit from ASV therapy. Early ASV usage was significantly associated with late ASV usage (univariable regression: Beta 0.8, 95%CI [0.6; 1.0] p < 0.001). In multivariable regression analysis, short duration of slow wave sleep (N3) during diagnostic polysomnography (Beta - 6.2, 95%CI [- 11.0; - 1.5]; p = 0.011) and subjective benefit from ASV (Beta 174.0, 95%CI [68.6; 279.5]; p = 0.002) were significantly associated with longer late ASV usage.!##!Conclusion!#!Early ASV usage predicts late ASV usage. In addition, low slow wave sleep before ASV initiation and subjective benefit from ASV may contribute to higher late ASV usage.
Document Type: Article
Other literature type
Language: English
ISSN: 1522-1709
1520-9512
DOI: 10.1007/s11325-020-02231-w
Access URL: https://link.springer.com/content/pdf/10.1007/s11325-020-02231-w.pdf
https://pubmed.ncbi.nlm.nih.gov/33089399
https://link.springer.com/article/10.1007/s11325-020-02231-w
https://link.springer.com/content/pdf/10.1007/s11325-020-02231-w.pdf
https://www.ncbi.nlm.nih.gov/pubmed/33089399
https://juser.fz-juelich.de/record/885837
https://repository.publisso.de/resource/frl:6468690
Rights: CC BY
Accession Number: edsair.doi.dedup.....9611a4f93a1e1b45f18ecb2c630a97fc
Database: OpenAIRE
Description
Abstract:Purpose!#!Adaptive servo-ventilation (ASV) is a therapy designed for patients with central sleep apnea (CSA) and Cheyne Stokes respiration. The aim of this study was to find predictors of ASV usage in patients with CSA in a routine sleep clinic cohort.!##!Methods!#!In this retrospective study, consecutive patients in whom ASV therapy was initiated at the University Hospital Regensburg between 2011 and 2015, were analyzed. Analysis included polysomnographies of diagnostic and ASV initiation nights, a phone questionnaire on ASV usage, readout of the ASV device 1 month after initiation ('early ASV usage,' 1 month after ASV initiation), and the readout of the last month before a reappointment date set in 2015 ('late ASV usage,' median 17 months after ASV initiation).!##!Results!#!In 69 consecutive patients, the mean early and late ASV usage per night was 4.8 ± 2.5 h and 4.1 ± 3.0 h, respectively. Seventeen months after initiation, 57% of patients used the device ≥ 4 h per night, and of those 91% reported a subjective benefit from ASV therapy. Early ASV usage was significantly associated with late ASV usage (univariable regression: Beta 0.8, 95%CI [0.6; 1.0] p < 0.001). In multivariable regression analysis, short duration of slow wave sleep (N3) during diagnostic polysomnography (Beta - 6.2, 95%CI [- 11.0; - 1.5]; p = 0.011) and subjective benefit from ASV (Beta 174.0, 95%CI [68.6; 279.5]; p = 0.002) were significantly associated with longer late ASV usage.!##!Conclusion!#!Early ASV usage predicts late ASV usage. In addition, low slow wave sleep before ASV initiation and subjective benefit from ASV may contribute to higher late ASV usage.
ISSN:15221709
15209512
DOI:10.1007/s11325-020-02231-w