Anogenital distance is associated with semen quality but not reproductive hormones in 1106 young men from the general population
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| Názov: | Anogenital distance is associated with semen quality but not reproductive hormones in 1106 young men from the general population |
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| Autori: | Marianna Krause, Lærke Priskorn, Anders Juul, Niels Jørgensen, Shanna H. Swan, Jaime Mendiola, Anne Kirstine Bang, Tina Kold Jensen, N E Skakkebaek, Loa Nordkap |
| Zdroj: | Priskorn, L, Bang, A K, Nordkap, L, Krause, M, Mendiola, J, Jensen, T K, Juul, A, Skakkebaek, N E, Swan, S H & Jørgensen, N 2019, ' Anogenital distance is associated with semen quality but not reproductive hormones in 1106 young men from the general population ', Human reproduction (Oxford, England), vol. 34, no. 1, pp. 12-24 . https://doi.org/10.1093/humrep/dey326 |
| Informácie o vydavateľovi: | Oxford University Press (OUP), 2018. |
| Rok vydania: | 2018 |
| Predmety: | Adult, Male, Fertility/physiology, Self Report/statistics & numerical data, AGDAS, Denmark, AGDAP, Anal Canal, Follicle Stimulating Hormone/blood, reproductive hormones, Estradiol/blood, Young Adult, 03 medical and health sciences, semen quality, 0302 clinical medicine, Semen, Humans, anogenital distance, Scrotum/anatomy & histology, Anal Canal/anatomy & histology, Penis/anatomy & histology, Anthropometry, Estradiol, Sperm Count, Semen/physiology, Luteinizing Hormone, 3. Good health, Cross-Sectional Studies, Fertility, 13. Climate action, Scrotum, Sperm Motility, Luteinizing Hormone/blood, Self Report, Follicle Stimulating Hormone, Sperm Motility/physiology, Penis |
| Popis: | Is anogenital distance (AGD) associated with semen quality and reproductive hormones in men from the general population?Short AGD measured from the anus to the base of scrotum (AGDAS) was associated with reduced sperm counts and morphology but not with sperm motility or reproductive hormones.AGD is longer in males than in females. In rodents, AGD is a well-established and sensitive marker of disruption during the masculinization programming window in utero and it has been suggested to be so in humans as well. Therefore, the average AGD would be expected to be shorter in men with poor semen quality, which some studies have confirmed while others have not.This cross-sectional population-based study was of 1106 men included between 2012 and 2016.Men from the general Danish population (median age 19 years), unselected with regard to fertility status and semen quality, delivered a semen sample, had a blood sample drawn, which was analyzed for concentrations of reproductive hormones, and answered a comprehensive questionnaire. They also had a physical examination performed including determination of AGD measured as the distance between anus and scrotum (AGDAS) and penis (AGDAP). Odds ratios (OR) and 95% CI were estimated for a man having abnormal semen parameters according to the World Health Organization's reference values or a low/high concentration of reproductive hormones (defined as the lowest or highest 10%) depending on AGD. AGD was categorized in four strata: ≤10th percentile, 10th-30th percentile, 30th-50th percentile and >50th percentile.Men with the 10% shortest AGDAS had a more than doubled risk (OR: 2.19, 95% CI: 1.40-3.42) of being in the subfertile range for either sperm concentration ( |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1460-2350 0268-1161 |
| DOI: | 10.1093/humrep/dey326 |
| Prístupová URL adresa: | https://academic.oup.com/humrep/article-pdf/34/1/12/27171474/dey326.pdf https://pubmed.ncbi.nlm.nih.gov/30452659 https://portal.findresearcher.sdu.dk/da/publications/anogenital-distance-is-associated-with-semen-quality-but-not-repr https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295959 https://pubmed.ncbi.nlm.nih.gov/30452659/ https://academic.oup.com/humrep/article/34/1/12/5185660 https://europepmc.org/article/MED/30452659 https://portal.findresearcher.sdu.dk/da/publications/f79d3b67-958b-44c0-bcbf-9b0206f0df5f |
| Rights: | OUP Standard Publication Reuse |
| Prístupové číslo: | edsair.doi.dedup.....95a2eda1e3727d984119fb71d6eba8d0 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Is anogenital distance (AGD) associated with semen quality and reproductive hormones in men from the general population?Short AGD measured from the anus to the base of scrotum (AGDAS) was associated with reduced sperm counts and morphology but not with sperm motility or reproductive hormones.AGD is longer in males than in females. In rodents, AGD is a well-established and sensitive marker of disruption during the masculinization programming window in utero and it has been suggested to be so in humans as well. Therefore, the average AGD would be expected to be shorter in men with poor semen quality, which some studies have confirmed while others have not.This cross-sectional population-based study was of 1106 men included between 2012 and 2016.Men from the general Danish population (median age 19 years), unselected with regard to fertility status and semen quality, delivered a semen sample, had a blood sample drawn, which was analyzed for concentrations of reproductive hormones, and answered a comprehensive questionnaire. They also had a physical examination performed including determination of AGD measured as the distance between anus and scrotum (AGDAS) and penis (AGDAP). Odds ratios (OR) and 95% CI were estimated for a man having abnormal semen parameters according to the World Health Organization's reference values or a low/high concentration of reproductive hormones (defined as the lowest or highest 10%) depending on AGD. AGD was categorized in four strata: ≤10th percentile, 10th-30th percentile, 30th-50th percentile and >50th percentile.Men with the 10% shortest AGDAS had a more than doubled risk (OR: 2.19, 95% CI: 1.40-3.42) of being in the subfertile range for either sperm concentration ( |
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| ISSN: | 14602350 02681161 |
| DOI: | 10.1093/humrep/dey326 |