View in EDS

HPV-associated anal lesions in HIV+ patients: long-term results regarding quality of life

Saved in:
Bibliographic Details
Title: HPV-associated anal lesions in HIV+ patients: long-term results regarding quality of life
Authors: Wesselmann, Paul, Schwarze-Zander, Carolynne, Boesecke, Christoph, Rockstroh, Jürgen, Stoffels, B., Vilz, Tim O., Glowka, Tim R., Kalff, J. C., von Websky, Martin W.
Source: Int J Colorectal Dis
Publisher Information: Springer Science and Business Media LLC, 2020.
Publication Year: 2020
Subject Terms: Adult, Male, 2. Zero hunger, Time Factors, Adolescent, Sexual Behavior, Middle Aged, Anus Neoplasms, 3. Good health, Surveys and Questionnaires [MeSH], Anus Neoplasms/complications [MeSH], Carcinoma in Situ/complications [MeSH], Anus Neoplasms/therapy [MeSH], Original Article, Condylomata Acuminata/complications [MeSH], Male [MeSH], Quality of Life [MeSH], HPV, Neoplasm Recurrence, Local [MeSH], Stress, Psychological/etiology [MeSH], Condylomata Acuminata/psychology [MeSH], Anus Neoplasms/psychology [MeSH], Condyloma, Adolescent [MeSH], Carcinoma in Situ/psychology [MeSH], Follow-Up Studies [MeSH], Adult [MeSH], Humans [MeSH], HIV, HIV Seropositivity/complications [MeSH], Sexual Behavior [MeSH], Middle Aged [MeSH], Time Factors [MeSH], Anus Neoplasms/pathology [MeSH], Anal intraepithelial neoplasia, Recurrence [MeSH], Quality of life, SF-36, Carcinoma in Situ/pathology [MeSH], Young Adult [MeSH], Condylomata Acuminata/therapy [MeSH], Carcinoma in Situ/therapy [MeSH], Young Adult, 03 medical and health sciences, 0302 clinical medicine, Condylomata Acuminata, Recurrence, Surveys and Questionnaires, HIV Seropositivity, Quality of Life, Humans, Neoplasm Recurrence, Local, 10. No inequality, Carcinoma in Situ, Stress, Psychological, Follow-Up Studies
Description: Purpose HIV infection and concomitant HPV-associated anal lesions may significantly impact on patients’ quality of life (QoL), as they are predicted to have negative effects on health, psyche, and sexuality. Material and methods Fifty-two HIV+ patients with HPV-associated anal lesions were enrolled in a survey approach after undergoing routine proctologic assessment and therapy for HPV-associated anal lesions if indicated over a time span of 11 years (11/2004–11/2015). Therapy consisted of surgical ablation and topic treatment. QoL was analyzed using the SF-36 and the CECA questionnaires. Results Fifty-two of 67 patients (77.6%) were successfully contacted and 29/52 provided full information. The mean age was 43.8 ± 12.8 years. The median follow-up from treatment to answering of the questionnaire was 34 months. Twenty-one percent (6/29) of the patients reported suffering from recurrence of condyloma acuminata, three patients from anal dysplasia (10.3%). In the SF-36, HIV+ patients did not rate their QoL as significantly different over all items after successful treatment of HPV-associated anal lesions. In the CECA questionnaire, patients with persisting HPV-associated anal lesions reported significantly higher emotional stress levels and disturbance of everyday life compared to patients who had successful treatment (71.9/100 ± 18.7 vs. 40.00/100 ± 27.4, p = 0.004). Importantly, the sexuality of patients with anal lesions was significantly impaired (59.8/100 ± 30.8 vs. 27.5/100 ± 12.2, p = 0.032). Conclusion HPV-associated anal lesions impact significantly negative on QoL in HIV+ patients. Successful treatment of HPV-associated anal lesions in HIV+ patients improved QoL. Specific questionnaires, such as CECA, seem to be more adequate than the SF-36 in this setting.
Document Type: Article
Other literature type
Language: English
ISSN: 1432-1262
0179-1958
DOI: 10.1007/s00384-020-03567-1
Access URL: https://link.springer.com/content/pdf/10.1007/s00384-020-03567-1.pdf
https://pubmed.ncbi.nlm.nih.gov/32215680
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245587
https://link.springer.com/content/pdf/10.1007/s00384-020-03567-1.pdf
https://www.ncbi.nlm.nih.gov/pubmed/32215680
https://link.springer.com/article/10.1007/s00384-020-03567-1
https://pubmed.ncbi.nlm.nih.gov/32215680/
https://europepmc.org/article/MED/32215680
https://repository.publisso.de/resource/frl:6469810
Rights: CC BY
Accession Number: edsair.doi.dedup.....951834642701e11a6c7e53918b2a8c1f
Database: OpenAIRE
Description
Abstract:Purpose HIV infection and concomitant HPV-associated anal lesions may significantly impact on patients’ quality of life (QoL), as they are predicted to have negative effects on health, psyche, and sexuality. Material and methods Fifty-two HIV+ patients with HPV-associated anal lesions were enrolled in a survey approach after undergoing routine proctologic assessment and therapy for HPV-associated anal lesions if indicated over a time span of 11 years (11/2004–11/2015). Therapy consisted of surgical ablation and topic treatment. QoL was analyzed using the SF-36 and the CECA questionnaires. Results Fifty-two of 67 patients (77.6%) were successfully contacted and 29/52 provided full information. The mean age was 43.8 ± 12.8 years. The median follow-up from treatment to answering of the questionnaire was 34 months. Twenty-one percent (6/29) of the patients reported suffering from recurrence of condyloma acuminata, three patients from anal dysplasia (10.3%). In the SF-36, HIV+ patients did not rate their QoL as significantly different over all items after successful treatment of HPV-associated anal lesions. In the CECA questionnaire, patients with persisting HPV-associated anal lesions reported significantly higher emotional stress levels and disturbance of everyday life compared to patients who had successful treatment (71.9/100 ± 18.7 vs. 40.00/100 ± 27.4, p = 0.004). Importantly, the sexuality of patients with anal lesions was significantly impaired (59.8/100 ± 30.8 vs. 27.5/100 ± 12.2, p = 0.032). Conclusion HPV-associated anal lesions impact significantly negative on QoL in HIV+ patients. Successful treatment of HPV-associated anal lesions in HIV+ patients improved QoL. Specific questionnaires, such as CECA, seem to be more adequate than the SF-36 in this setting.
ISSN:14321262
01791958
DOI:10.1007/s00384-020-03567-1