Higher Postoperative Mortality and Inferior Survival After Right-Sided Liver Resection for Perihilar Cholangiocarcinoma: Left-Sided Resection is Preferred When Possible: Left-Sided Resection is Preferred When Possible
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Higher Postoperative Mortality and Inferior Survival After Right-Sided Liver Resection for Perihilar Cholangiocarcinoma: Left-Sided Resection is Preferred When Possible: Left-Sided Resection is Preferred When Possible
Institut Català de la Salut, [Olthof PB] Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands. Department of Surgery, Amsterdam UMC, Amsterdam, The Netherlands. Department of Surgery, University Medical Center, Groningen, Groningen, The Netherlands. [Erdmann JI] Department of Surgery, Amsterdam UMC, Amsterdam, The Netherlands. [Alikhanov R] Department of Liver and Pancreatic Surgery, Department of Transplantation, Moscow Clinical Scientifc Centre, Moscow, Russia. [Charco R] Servei de Cirurgia Hepatobiliopancreàtica i Trasplantaments, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Guglielmi A] Division of General Surgery, Department of Surgery, Unit of Hepato-Pancreato-Biliary Surgery, University of Verona Medical School, Verona, Italy. [Hagendoorn J] Department of Surgical Oncology, University Medical Centre/Utrecht University, Utrecht, The Netherlands, Vall d'Hebron Barcelona Hospital Campus
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Ann Surg Oncol Scientia Scientia. Dipòsit d'Informació Digital del Departament de Salut instname
Background A right- or left-sided liver resection can be considered in about half of patients with perihilar cholangiocarcinoma (pCCA), depending on tumor location and vascular involvement. This study compared postoperative mortality and long-term survival of right- versus left-sided liver resections for pCCA. Methods Patients who underwent major liver resection for pCCA at 25 Western centers were stratified according to the type of hepatectomy—left, extended left, right, and extended right. The primary outcomes were 90-day mortality and overall survival (OS). Results Between 2000 and 2022, 1701 patients underwent major liver resection for pCCA. The 90-day mortality was 9% after left-sided and 18% after right-sided liver resection (p p p p Conclusions A left or extended left hepatectomy is associated with a lower 90-day mortality and superior OS compared with an (extended) right hepatectomy for pCCA. When both a left and right liver resection are feasible, a left-sided liver resection is preferred.
Background A right- or left-sided liver resection can be considered in about half of patients with perihilar cholangiocarcinoma (pCCA), depending on tumor location and vascular involvement. This study compared postoperative mortality and long-term survival of right- versus left-sided liver resections for pCCA. Methods Patients who underwent major liver resection for pCCA at 25 Western centers were stratified according to the type of hepatectomy—left, extended left, right, and extended right. The primary outcomes were 90-day mortality and overall survival (OS). Results Between 2000 and 2022, 1701 patients underwent major liver resection for pCCA. The 90-day mortality was 9% after left-sided and 18% after right-sided liver resection (p p p p Conclusions A left or extended left hepatectomy is associated with a lower 90-day mortality and superior OS compared with an (extended) right hepatectomy for pCCA. When both a left and right liver resection are feasible, a left-sided liver resection is preferred.
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