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The application of ultrasound shear wave elastography in the prediction of paradoxical upgrading reaction in tuberculous lymphadenitis. a pilot study

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Název: The application of ultrasound shear wave elastography in the prediction of paradoxical upgrading reaction in tuberculous lymphadenitis. a pilot study
Autoři: Yen-Lin Chen, Yao-Wen Kuo, Huey-Dong Wu, Jann-Yuan Wang, Hao-Chien Wang
Zdroj: Journal of the Formosan Medical Association, Vol 121, Iss 9, Pp 1696-1704 (2022)
Informace o vydavateli: Elsevier BV, 2022.
Rok vydání: 2022
Témata: Adult, Tuberculous lymphadenitis, Medicine (General), Extra-pulmonary tuberculosis, Pilot Projects, Middle Aged, Tuberculosis, Lymph Node, Sensitivity and Specificity, 3. Good health, 03 medical and health sciences, R5-920, 0302 clinical medicine, Paradoxical upgrading reaction, Response assessment, Shear wave elastography, Elasticity Imaging Techniques, Humans, Female, Aged, Ultrasonography
Popis: Paradoxical upgrading reaction (PUR) indicates the unanticipated deterioration during therapy in patients with tuberculous lymphadenitis. We investigated the diagnostic performance of the ultrasonography and shear wave elastography (SWE) in predicting the therapeutic response of peripheral tuberculous lymphadenitis.A prospective observational study was conducted from December 2017 to August 2020. Participants diagnosed with peripheral tuberculous lymphadenitis were included for a longitudinal follow-up utilizing ultrasonography with two-dimensional SWE to record sonographic features and the maximum elasticity value (Emax). We defined PUR as the development of any worsening symptoms of the pre-existing lymphadenitis within one month after the previous ultrasonography.A total of 108 sonographic and SWE examinations were performed in 20 enrollees (75% woman), and their mean ( ± standard deviation) age was 49.6 ( ± 22.7) years. The area under the receiver operating characteristic curve of Emax to predict the next-month PUR was 0.906 at the cut-point of 85 kPa, with an accuracy of 87.0%, a sensitivity of 81.1% and a specificity of 87.9%. Multivariate analysis indicated that Emax > 85 kPa (OR: 24.85, 95% CI: 4.01-154.08, p 2 kPa/month (OR: 15.14, 95% CI: 4.24-54.06, p
Druh dokumentu: Article
Jazyk: English
ISSN: 0929-6646
DOI: 10.1016/j.jfma.2021.12.002
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/34953644
https://doaj.org/article/cece0c5f127f4f0e93966ff105c02db6
Rights: CC BY NC ND
Přístupové číslo: edsair.doi.dedup.....933a7f60da92656cf52a2fd36663773f
Databáze: OpenAIRE
Popis
Abstrakt:Paradoxical upgrading reaction (PUR) indicates the unanticipated deterioration during therapy in patients with tuberculous lymphadenitis. We investigated the diagnostic performance of the ultrasonography and shear wave elastography (SWE) in predicting the therapeutic response of peripheral tuberculous lymphadenitis.A prospective observational study was conducted from December 2017 to August 2020. Participants diagnosed with peripheral tuberculous lymphadenitis were included for a longitudinal follow-up utilizing ultrasonography with two-dimensional SWE to record sonographic features and the maximum elasticity value (Emax). We defined PUR as the development of any worsening symptoms of the pre-existing lymphadenitis within one month after the previous ultrasonography.A total of 108 sonographic and SWE examinations were performed in 20 enrollees (75% woman), and their mean ( ± standard deviation) age was 49.6 ( ± 22.7) years. The area under the receiver operating characteristic curve of Emax to predict the next-month PUR was 0.906 at the cut-point of 85 kPa, with an accuracy of 87.0%, a sensitivity of 81.1% and a specificity of 87.9%. Multivariate analysis indicated that Emax > 85 kPa (OR: 24.85, 95% CI: 4.01-154.08, p 2 kPa/month (OR: 15.14, 95% CI: 4.24-54.06, p
ISSN:09296646
DOI:10.1016/j.jfma.2021.12.002