Acute febrile encephalopathy and seizures in children with diffusion restriction lesions on magnetic resonance imaging brain: A case series
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| Title: | Acute febrile encephalopathy and seizures in children with diffusion restriction lesions on magnetic resonance imaging brain: A case series |
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| Authors: | Bhakti Sarangi, SaiDivya Sasi Kumar, VenkatSandeep Reddy, Ajay Walimbe |
| Source: | Journal of Pediatric Critical Care, Vol 8, Iss 1, Pp 42-46 (2021) |
| Publisher Information: | Medknow, 2021. |
| Publication Year: | 2021 |
| Subject Terms: | 03 medical and health sciences, pediatric, 0302 clinical medicine, diffusion restriction, acute febrile encephalopathy, Pediatrics, RJ1-570, seizures, 3. Good health |
| Description: | Over the last decade, several entities within the spectrum of acute febrile encephalopathy (AFE) including acute disseminated encephalomyelitis, acute necrotizing encephalitis, fever-induced refractory epilepsy syndrome, clinically mild encephalopathy with reversible splenial lesion, and autoimmune encephalitis have been recognized, all of which now have reasonably well-established clinicoradiological diagnostic criteria and therapeutic options. This case series highlights the clinical profile and outcome of seven children with the lesser-known entity of AFE with seizures and white matter diffusion restriction lesions on magnetic resonance imaging. All children had a history of acute onset fever, altered sensorium, and refractory seizures requiring multiple antiepileptic drugs and presented in shock requiring multiple organ support. All had extensive, diffusion-restricted lesions involving white matter. The infectious trigger was identified as influenza A (H3N2) in case 1, dengue virus in cases 2 and 6, and influenza B in case 4. Five children survived, each of whom had significant neurological sequelae. |
| Document Type: | Article Other literature type |
| Language: | English |
| ISSN: | 2349-6592 |
| DOI: | 10.4103/jpcc.jpcc_132_20 |
| Access URL: | https://doaj.org/article/da001bb2a98e4886b658f2bb88554842 https://jpcc.org.in/article.asp?issn=2349-6592;year=2021;volume=8;issue=1;spage=42;epage=46;aulast=Sasi http://jpcc.org.in/article.asp?issn=2349-6592;year=2021;volume=8;issue=1;spage=42;epage=46;aulast=Sasi |
| Rights: | CC BY NC SA |
| Accession Number: | edsair.doi.dedup.....93385e269c81a2e1d643a444527aa1d1 |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Over the last decade, several entities within the spectrum of acute febrile encephalopathy (AFE) including acute disseminated encephalomyelitis, acute necrotizing encephalitis, fever-induced refractory epilepsy syndrome, clinically mild encephalopathy with reversible splenial lesion, and autoimmune encephalitis have been recognized, all of which now have reasonably well-established clinicoradiological diagnostic criteria and therapeutic options. This case series highlights the clinical profile and outcome of seven children with the lesser-known entity of AFE with seizures and white matter diffusion restriction lesions on magnetic resonance imaging. All children had a history of acute onset fever, altered sensorium, and refractory seizures requiring multiple antiepileptic drugs and presented in shock requiring multiple organ support. All had extensive, diffusion-restricted lesions involving white matter. The infectious trigger was identified as influenza A (H3N2) in case 1, dengue virus in cases 2 and 6, and influenza B in case 4. Five children survived, each of whom had significant neurological sequelae. |
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| ISSN: | 23496592 |
| DOI: | 10.4103/jpcc.jpcc_132_20 |