Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
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| Title: | Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data |
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| Authors: | Yoichiro Kamatani, Yau Hua Yu, Marju Orho-Melander, Vuokko Anttonen, Paul M. Ridker, Marja Laitala, Daniel I. Chasman, Tamar Sofer, Takeaki Sudo, Kimon Divaris, George Hindy, Saori Sakaue, Franco Giulianini, John R. Shaffer, Paul W. Franks, Yukinori Okada, Birte Holtfreter, Myoung Keun Lee, Mary L. Marazita, Erik Ingelsson, Paula Pesonen, Ingegerd Johansson, Dmitry Shungin, Yasushi Furuichi, Uwe Völker, Michiaki Kubo, Nicholas J. Timpson, Jun Hirata, Kelsey Grinde, Kari E. North, Patrik K. E. Magnusson, Viivi Alaraudanjoki, Alexandre R. Vieira, Cary S. Agler, Alexander Teumer, Thomas Kocher, Simon Haworth, S. Offenbacher |
| Source: | Nat Commun Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019) Shungin, D, Haworth, S, Divaris, K, Agler, C, Kamatani, Y, Lee, M K, Grinde, K, Hindy, G, Viivi Alaraudanjoki, V, Pesonen, P, Teumer, A, Holtfreter, B, Sakaue, S, Hirata, J, Yu, Y-H, Ridker, P, Giulianini, F, Chasman, D I, Magnusson, P K E, Sudo, T, Okada, Y, Völker, U, Kocher, T, Anttonen, V, Laitala, M-L, Orho-Melander, M, Sofer, T, Shaffer, J R, Vieira, A, Marazita, M L, Kubo, M, Furuichi, Y, North, K, Offenbacher, S, Ingelsson, E, Franks, P W, Timpson, N & Johansson, I 2019, 'Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data', Nature Communications, vol. 10, 2773. https://doi.org/10.1038/s41467-019-10630-1 |
| Publisher Information: | Springer Science and Business Media LLC, 2019. |
| Publication Year: | 2019 |
| Subject Terms: | 0301 basic medicine, Heredity, Self Report/statistics & numerical data, Science, Quantitative Trait Loci, Dental Caries, Odontologi, Polymorphism, Single Nucleotide, Article, Periodontitis/epidemiology, 03 medical and health sciences, 5. Gender equality, Humans, Genetic Predisposition to Disease, Polymorphism, Periodontitis, 2. Zero hunger, 0303 health sciences, Single Nucleotide, Genomics, Mendelian Randomization Analysis, 3. Good health, Dentistry, Self Report, Quantitative Trait Loci/genetics, Dental Caries/epidemiology, Genome-Wide Association Study |
| Description: | Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence suggesting that the processes contributing to dental caries may have undesirable downstream effects on health. |
| Document Type: | Article Conference object Other literature type |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-019-10630-1 |
| Access URL: | https://www.nature.com/articles/s41467-019-10630-1.pdf https://pubmed.ncbi.nlm.nih.gov/31235808 https://doaj.org/article/9c0e19f3136944e4b0b2db9b41f36485 https://europepmc.org/article/MED/31235808 https://pubmed.ncbi.nlm.nih.gov/31235808/ http://www.diva-portal.org/smash/record.jsf?pid=diva2:1338348 https://www.nature.com/articles/s41467-019-10630-1.pdf https://lup.lub.lu.se/search/publication/faec2925-abee-4bb5-bac4-9623c97f3fce https://research-information.bris.ac.uk/files/199452352/s41467_019_10630_1.pdf http://urn.fi/urn:nbn:fi-fe202003127980 https://research-information.bris.ac.uk/en/publications/83a16783-854b-48cf-867e-6bc247f2d20c https://hdl.handle.net/1983/83a16783-854b-48cf-867e-6bc247f2d20c http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161588 https://publications.scilifelab.se/publication/cb37677921194ab3a4e0306fa262a79c |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....92bb0867b5007b1726a7bda7e5e9c29b |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence suggesting that the processes contributing to dental caries may have undesirable downstream effects on health. |
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| ISSN: | 20411723 |
| DOI: | 10.1038/s41467-019-10630-1 |