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The Intersectoral Coordination Unit for the Sustainable Intensification of Peritoneal Dialysis in Schleswig–Holstein (SKIP-SH) cohort study

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Title: The Intersectoral Coordination Unit for the Sustainable Intensification of Peritoneal Dialysis in Schleswig–Holstein (SKIP-SH) cohort study
Authors: Wülfrath, Hauke S., Schrumpf, Thorben, von Samson-Himmelstjerna, Friedrich A., Voran, Jakob, Zhang, Yao, Esser, Grit, Thomsen, Sarah-Yasmin, Messtorff, Maja L., Riebeling, Theresa, Kakavand, Nassim, Schmitt, Roland, Schulte, Kevin, Kolbrink, Benedikt
Source: BMC Nephrol
BMC Nephrology, Vol 25, Iss 1, Pp 1-7 (2024)
Publisher Information: Springer Science and Business Media LLC, 2024.
Publication Year: 2024
Subject Terms: Quality of life, Biobanking, Peritoneal dialysis, Biocompatible Materials, Diseases of the genitourinary system. Urology, 12. Responsible consumption, 3. Good health, Cohort Studies, End-stage renal disease, Study Protocol, 03 medical and health sciences, 0302 clinical medicine, Peritoneal Dialysis [MeSH], Disease Progression [MeSH], Humans [MeSH], Prospective Studies [MeSH], Prospective cohort study, Biocompatible Materials [MeSH], Cohort Studies [MeSH], Quality of Life [MeSH], Renal Insufficiency, Chronic/therapy [MeSH], Renal Insufficiency, Chronic/epidemiology [MeSH], Kidney replacement therapy, Kidney Failure, Chronic/epidemiology [MeSH], Renal Dialysis/adverse effects [MeSH], Renal Dialysis, Quality of Life, Disease Progression, Humans, Kidney Failure, Chronic, RC870-923, Prospective Studies, Renal Insufficiency, Chronic, Peritoneal Dialysis
Description: Background Peritoneal dialysis (PD) remains underutilised in Germany, prompting the initiation of the Sustainable Intensification of Peritoneal Dialysis in Schleswig–Holstein (SKIP-SH) project. The SKIP-SH cohort study aims to demonstrate the presumed benefits of PD, including enhanced quality of life and reduced healthcare personnel requirements, and to generate data to strengthen the use of PD. Methods The prospective SKIP-SH cohort study recruits patients with advanced chronic kidney disease (CKD) and their caregivers. Comprehensive data, including demographic information, medical history, clinical course, laboratory data, and quality-of-life assessments, are collected. Additionally, biomaterials will be obtained. Primary study objectives are documenting the clinical course and complications, time on therapy for new dialysis patients, reasons influencing treatment modality choices, circumstances at the initiation of dialysis, and quality of life for patients with CKD and their caregivers. The collected biomaterials will serve as a basis for further translational research. Secondary objectives include identifying factors impacting disease-related quality of life, clinical complications, and therapy dropout, estimating ecological footprints, and evaluating healthcare costs and labour time for initiating and sustaining PD treatment. Discussion PD is notably underutilised in Germany. The current therapy approach for advanced CKD often lacks emphasis on patient-focused care and quality-of-life considerations. Furthermore, adequate explorative research programs to improve our knowledge of mechanisms leading to disease progression and therapy failure in PD patients are scarce. The overarching goal of the SKIP-SH cohort study is to address the notably low PD prevalence in Germany whilst advocating for a shift towards patient-focused care, quality-of-life considerations, and robust translational research. Trial registration This study was registered with the German trial registry (Deutsches Register klinischer Studien) on November 7, 2023, under trial number DRKS00032983.
Document Type: Article
Other literature type
Language: English
ISSN: 1471-2369
DOI: 10.1186/s12882-024-03519-9
Access URL: https://pubmed.ncbi.nlm.nih.gov/38429741
https://doaj.org/article/fd6c74d62b6c46bcbefe7c34d77ab353
https://repository.publisso.de/resource/frl:6523482
Rights: CC BY
URL: http://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (http://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Accession Number: edsair.doi.dedup.....91de5059c7f7d86aa8be79e21336ef2d
Database: OpenAIRE
Description
Abstract:Background Peritoneal dialysis (PD) remains underutilised in Germany, prompting the initiation of the Sustainable Intensification of Peritoneal Dialysis in Schleswig–Holstein (SKIP-SH) project. The SKIP-SH cohort study aims to demonstrate the presumed benefits of PD, including enhanced quality of life and reduced healthcare personnel requirements, and to generate data to strengthen the use of PD. Methods The prospective SKIP-SH cohort study recruits patients with advanced chronic kidney disease (CKD) and their caregivers. Comprehensive data, including demographic information, medical history, clinical course, laboratory data, and quality-of-life assessments, are collected. Additionally, biomaterials will be obtained. Primary study objectives are documenting the clinical course and complications, time on therapy for new dialysis patients, reasons influencing treatment modality choices, circumstances at the initiation of dialysis, and quality of life for patients with CKD and their caregivers. The collected biomaterials will serve as a basis for further translational research. Secondary objectives include identifying factors impacting disease-related quality of life, clinical complications, and therapy dropout, estimating ecological footprints, and evaluating healthcare costs and labour time for initiating and sustaining PD treatment. Discussion PD is notably underutilised in Germany. The current therapy approach for advanced CKD often lacks emphasis on patient-focused care and quality-of-life considerations. Furthermore, adequate explorative research programs to improve our knowledge of mechanisms leading to disease progression and therapy failure in PD patients are scarce. The overarching goal of the SKIP-SH cohort study is to address the notably low PD prevalence in Germany whilst advocating for a shift towards patient-focused care, quality-of-life considerations, and robust translational research. Trial registration This study was registered with the German trial registry (Deutsches Register klinischer Studien) on November 7, 2023, under trial number DRKS00032983.
ISSN:14712369
DOI:10.1186/s12882-024-03519-9