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Effect of an 18-month meditation training on cardiovascular risk in older adults: a secondary analysis of the Age-Well randomized controlled trial

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Název: Effect of an 18-month meditation training on cardiovascular risk in older adults: a secondary analysis of the Age-Well randomized controlled trial
Autoři: Antoine Garnier-Crussard, Julie Gonneaud, Francesca Felisatti, Cassandre Palix, Eglantine Ferrand Devouge, Anne Chocat, Géraldine Rauchs, Vincent de la Sayette, Denis Vivien, Harriet Demnitz-King, Antoine Lutz, Gaël Chételat, Géraldine Poisnel, the Medit-Ageing Research Group
Přispěvatelé: lutz, antoine, Physiopathologie et imagerie des troubles neurologiques (PhIND), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital des Charpennes CHU - HCL, Hospices Civils de Lyon (HCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Normandie Université (NU), Institut Blood and Brain @ Caen-Normandie Caen (BB@C), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Institut National de la Santé et de la Recherche Médicale (INSERM), GIP Cyceron (Cyceron), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Rouen, Centre d'Investigation Clinique CHU Rouen (CIC Rouen), Hôpital Charles Nicolle Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Neurologie CHU Caen, Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Division of Psychiatry London, UK, University College of London London (UCL), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), European Project: 667696,H2020,H2020-PHC-2015-two-stage,MEDIT-AGEING(2016)
Zdroj: BMC Geriatr
BMC Geriatrics, Vol 24, Iss 1, Pp 1-10 (2024)
Informace o vydavateli: Springer Science and Business Media LLC, 2024.
Rok vydání: 2024
Témata: NCT02977819 Cardiovascular risk factor, Male, Aged, 80 and over, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, NCT02977819 Cardiovascular risk factor Metabolic risk factor Meditation Mindfulness Randomized controlled trial, Research, RC952-954.6, Cardiovascular risk factor, 03 medical and health sciences, Metabolic risk factor, Meditation, 0302 clinical medicine, Randomized controlled trial, Geriatrics, Cardiovascular Diseases, Heart Disease Risk Factors, Humans, Female, Independent Living, Mindfulness, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Aged
Popis: Cardiovascular risk factors represent an important health issue in older adults. Previous findings suggest that meditation training could have a positive impact on these risk factors. The objective of this study was to investigate the effects of an 18-month meditation-based intervention on cardiovascular health.Age-Well was a randomized, controlled superiority trial with blinded end point assessment, including community-dwelling cognitively unimpaired adults 65 years and older enrolled between November 24, 2016, and March 5, 2018, in France. One hundred and thirty-four participants were included in this secondary analysis. Participants were randomly affected to an intervention group that received an 18-month meditation-based program or to comparison groups (active control group i.e. non-native language training or passive control group i.e. no intervention). The main outcome was change in the Framingham Risk Score (FRS); other outcomes were changes in cardiovascular and metabolic risk factors.There was no difference in FRS change after 18 months between trial arms (p = .38). When assessing individual cardiovascular or metabolic risk factors, meditation training was associated with a greater reduction in diastolic blood pressure than the comparison group in participants with intermediate to high cardiovascular risk (FRS > 10%) at baseline (p = .03).An 18-month meditation training was not effective to increase overall cardiovascular health in older adults, but improved diastolic blood pressure in a subgroup analysis including at-risk participants. These results suggest a potential benefit of a long-term meditation intervention in older adults at-risk of cardiovascular diseases, and highlights the need for future research in more targeted populations.ClinicalTrials.gov Identifier: NCT02977819.
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1471-2318
DOI: 10.1186/s12877-024-05550-9
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39550530
https://doaj.org/article/bb479e06834d4bbabf1c19fbb871852f
https://hal.science/hal-04810245v1
https://doi.org/10.1186/s12877-024-05550-9
Rights: CC BY NC ND
Přístupové číslo: edsair.doi.dedup.....90bc005271fd7edcd1c9391bb06e726e
Databáze: OpenAIRE
Popis
Abstrakt:Cardiovascular risk factors represent an important health issue in older adults. Previous findings suggest that meditation training could have a positive impact on these risk factors. The objective of this study was to investigate the effects of an 18-month meditation-based intervention on cardiovascular health.Age-Well was a randomized, controlled superiority trial with blinded end point assessment, including community-dwelling cognitively unimpaired adults 65 years and older enrolled between November 24, 2016, and March 5, 2018, in France. One hundred and thirty-four participants were included in this secondary analysis. Participants were randomly affected to an intervention group that received an 18-month meditation-based program or to comparison groups (active control group i.e. non-native language training or passive control group i.e. no intervention). The main outcome was change in the Framingham Risk Score (FRS); other outcomes were changes in cardiovascular and metabolic risk factors.There was no difference in FRS change after 18 months between trial arms (p = .38). When assessing individual cardiovascular or metabolic risk factors, meditation training was associated with a greater reduction in diastolic blood pressure than the comparison group in participants with intermediate to high cardiovascular risk (FRS > 10%) at baseline (p = .03).An 18-month meditation training was not effective to increase overall cardiovascular health in older adults, but improved diastolic blood pressure in a subgroup analysis including at-risk participants. These results suggest a potential benefit of a long-term meditation intervention in older adults at-risk of cardiovascular diseases, and highlights the need for future research in more targeted populations.ClinicalTrials.gov Identifier: NCT02977819.
ISSN:14712318
DOI:10.1186/s12877-024-05550-9