Cortical thinning and associated connectivity changes in patients with anorexia nervosa
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| Názov: | Cortical thinning and associated connectivity changes in patients with anorexia nervosa |
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| Autori: | Feliberto de la Cruz, Andy Schumann, Stefanie Suttkus, Nadin Helbing, Regine Zopf, Karl-Jürgen Bär |
| Zdroj: | Transl Psychiatry Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021) |
| Informácie o vydavateľovi: | Springer Science and Business Media LLC, 2021. |
| Rok vydania: | 2021 |
| Predmety: | 2. Zero hunger, Brain Mapping, Anorexia Nervosa, Brain, Neurosciences. Biological psychiatry. Neuropsychiatry, Cerebral Cortical Thinning, Magnetic Resonance Imaging, Article, 3. Good health, 03 medical and health sciences, Cross-Sectional Studies, 0302 clinical medicine, Magnetic Resonance Imaging [MeSH], Brain/diagnostic imaging [MeSH], Neuroscience, Humans [MeSH], Brain Mapping [MeSH], Anorexia Nervosa/diagnostic imaging [MeSH], Psychiatric disorders, Cross-Sectional Studies [MeSH], Neural Pathways/diagnostic imaging [MeSH], Cerebral Cortical Thinning [MeSH], Neural Pathways, Humans, 10. No inequality, RC321-571 |
| Popis: | Structural brain abnormalities are a consistent finding in anorexia nervosa (AN) and proposed as a state biomarker of the disorder. Yet little is known about how regional structural changes affect intrinsic resting-state functional brain connectivity (rsFC). Using a cross-sectional, multimodal imaging approach, we investigated the association between regional cortical thickness abnormalities and rsFC in AN. Twenty-two acute AN patients and twenty-six age- and gender-matched healthy controls underwent a resting-state functional magnetic resonance imaging scan and cognitive tests. We performed group comparisons of whole-brain cortical thickness, seed-based rsFC, and network-based statistical (NBS) analyses. AN patients showed cortical thinning in the precuneus and inferior parietal lobules, regions involved in visuospatial memory and imagery. Cortical thickness in the precuneus correlated with nutritional state and cognitive functions in AN, strengthening the evidence for a critical role of this region in the disorder. Cortical thinning was accompanied by functional connectivity reductions in major brain networks, namely default mode, sensorimotor and visual networks. Similar to the seed-based approach, the NBS analysis revealed a single network of reduced functional connectivity in patients, comprising mainly sensorimotor- occipital regions. Our findings provide evidence that structural and functional brain abnormalities in AN are confined to specific regions and networks involved in visuospatial and somatosensory processing. We show that structural changes of the precuneus are linked to nutritional and functional states in AN, and future longitudinal research should assess how precuneus changes might be related to the evolution of the disorder. |
| Druh dokumentu: | Article Conference object Other literature type |
| Jazyk: | English |
| ISSN: | 2158-3188 |
| DOI: | 10.1038/s41398-021-01237-6 |
| Prístupová URL adresa: | https://www.nature.com/articles/s41398-021-01237-6.pdf https://pubmed.ncbi.nlm.nih.gov/33542197 https://doaj.org/article/fa44176b13e14865b7bbea7ea92e5ee0 https://www.ncbi.nlm.nih.gov/pubmed/33542197 https://pubmed.ncbi.nlm.nih.gov/33542197/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862305 https://www.nature.com/articles/s41398-021-01237-6 https://www.nature.com/articles/s41398-021-01237-6.pdf https://researchers.mq.edu.au/en/publications/cortical-thinning-and-associated-connectivity-changes-in-patients https://repository.publisso.de/resource/frl:6442548 |
| Rights: | CC BY |
| Prístupové číslo: | edsair.doi.dedup.....8fda1cd3f8da6dffffac6d38f22effed |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Structural brain abnormalities are a consistent finding in anorexia nervosa (AN) and proposed as a state biomarker of the disorder. Yet little is known about how regional structural changes affect intrinsic resting-state functional brain connectivity (rsFC). Using a cross-sectional, multimodal imaging approach, we investigated the association between regional cortical thickness abnormalities and rsFC in AN. Twenty-two acute AN patients and twenty-six age- and gender-matched healthy controls underwent a resting-state functional magnetic resonance imaging scan and cognitive tests. We performed group comparisons of whole-brain cortical thickness, seed-based rsFC, and network-based statistical (NBS) analyses. AN patients showed cortical thinning in the precuneus and inferior parietal lobules, regions involved in visuospatial memory and imagery. Cortical thickness in the precuneus correlated with nutritional state and cognitive functions in AN, strengthening the evidence for a critical role of this region in the disorder. Cortical thinning was accompanied by functional connectivity reductions in major brain networks, namely default mode, sensorimotor and visual networks. Similar to the seed-based approach, the NBS analysis revealed a single network of reduced functional connectivity in patients, comprising mainly sensorimotor- occipital regions. Our findings provide evidence that structural and functional brain abnormalities in AN are confined to specific regions and networks involved in visuospatial and somatosensory processing. We show that structural changes of the precuneus are linked to nutritional and functional states in AN, and future longitudinal research should assess how precuneus changes might be related to the evolution of the disorder. |
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| ISSN: | 21583188 |
| DOI: | 10.1038/s41398-021-01237-6 |