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Neural correlates and predictors of subjective cognitive decline in patients with Parkinson’s disease

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Název: Neural correlates and predictors of subjective cognitive decline in patients with Parkinson’s disease
Autoři: Anja Ophey, Fabian Krohm, Elke Kalbe, Andrea Greuel, Alexander Drzezga, Marc Tittgemeyer, Lars Timmermann, Frank Jessen, Carsten Eggers, Franziska Maier
Zdroj: Neurol Sci
Neurological sciences 43(5), 3153-3163 (2022). doi:10.1007/s10072-021-05734-w
Neurological sciences 43, 3153–3163 (2022). doi:10.1007/s10072-021-05734-w
Informace o vydavateli: Springer Science and Business Media LLC, 2021.
Rok vydání: 2021
Témata: Male, Positron emission tomography, diagnostic imaging [Cognitive Dysfunction], Neuropsychological Tests, etiology [Cognitive Dysfunction], 03 medical and health sciences, 0302 clinical medicine, Fluorodeoxyglucose F18, diagnostic imaging [Parkinson Disease], Humans, Cognitive Dysfunction, ddc:610, Retrospective Studies, Neural correlates, Predictors, Parkinson Disease, 3. Good health, Female [MeSH], Subjective cognitive decline, Parkinson disease, Parkinson Disease/complications [MeSH], Humans [MeSH], Cognitive Dysfunction/etiology [MeSH], Retrospective Studies [MeSH], Fluorodeoxyglucose F18 [MeSH], Original Article, Parkinson Disease/diagnostic imaging [MeSH], Male [MeSH], Cognitive Dysfunction/diagnostic imaging [MeSH], Positron-Emission Tomography [MeSH], Neuropsychological Tests [MeSH], Positron-Emission Tomography, Female, complications [Parkinson Disease]
Popis: Background Subjective cognitive decline (SCD) may occur very early in the course of Parkinson’s disease (PD) before the onset of objective cognitive decline. Data on neural correlates and determinants of SCD in PD are rare. Objective The aim of the present study was to identify neural correlates as well as sociodemographic, clinical, and neuropsychological predictors of SCD in patients with PD. Methods We retrospectively analyzed 30 patients with PD without cognitive impairment (23% female, 66.90 ± 7.20 years, UPDRS-III: 19.83 ± 9.29), of which n = 12 patients were classified as having no SCD (control group, PD-CG) and n = 18 as having SCD (PD-SCD). Neuropsychological testing and 18-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) were conducted. SCD was assessed using a questionnaire covering multiple cognitive domains. Results SCD subscores differed significantly between PD-CG and PD-SCD and correlated significantly with other scales measuring related concepts. FDG-PET whole-brain voxel-wise regression analysis revealed hypometabolism in middle frontal, middle temporal, and occipital areas, and the angular gyrus as neural correlates of SCD in PD. Next to this hypometabolism, depressive symptoms were an independent significant determinant of SCD in a stepwise regression analysis (adjusted R2 = 50.3%). Conclusion This study strengthens the hypothesis of SCD being an early manifestation of future cognitive decline in PD and, more generally, early pathological changes in PD. The early identification of the vulnerability for future cognitive decline constitutes the basis for successful prevention and delay of this non-motor symptom.
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1590-3478
1590-1874
DOI: 10.1007/s10072-021-05734-w
Přístupová URL adresa: https://link.springer.com/content/pdf/10.1007/s10072-021-05734-w.pdf
https://pubmed.ncbi.nlm.nih.gov/34820745
https://www.ncbi.nlm.nih.gov/pubmed/34820745
https://juser.fz-juelich.de/record/904370
https://repository.publisso.de/resource/frl:6448997
Rights: CC BY
URL: http://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) .
Přístupové číslo: edsair.doi.dedup.....8ea6a4891a48b2880c404843c3375cdc
Databáze: OpenAIRE
Popis
Abstrakt:Background Subjective cognitive decline (SCD) may occur very early in the course of Parkinson’s disease (PD) before the onset of objective cognitive decline. Data on neural correlates and determinants of SCD in PD are rare. Objective The aim of the present study was to identify neural correlates as well as sociodemographic, clinical, and neuropsychological predictors of SCD in patients with PD. Methods We retrospectively analyzed 30 patients with PD without cognitive impairment (23% female, 66.90 ± 7.20 years, UPDRS-III: 19.83 ± 9.29), of which n = 12 patients were classified as having no SCD (control group, PD-CG) and n = 18 as having SCD (PD-SCD). Neuropsychological testing and 18-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) were conducted. SCD was assessed using a questionnaire covering multiple cognitive domains. Results SCD subscores differed significantly between PD-CG and PD-SCD and correlated significantly with other scales measuring related concepts. FDG-PET whole-brain voxel-wise regression analysis revealed hypometabolism in middle frontal, middle temporal, and occipital areas, and the angular gyrus as neural correlates of SCD in PD. Next to this hypometabolism, depressive symptoms were an independent significant determinant of SCD in a stepwise regression analysis (adjusted R2 = 50.3%). Conclusion This study strengthens the hypothesis of SCD being an early manifestation of future cognitive decline in PD and, more generally, early pathological changes in PD. The early identification of the vulnerability for future cognitive decline constitutes the basis for successful prevention and delay of this non-motor symptom.
ISSN:15903478
15901874
DOI:10.1007/s10072-021-05734-w