In EDS ansehen

Neuropsychiatric symptoms in cognitive decline and Alzheimer’s disease: biomarker discovery using plasma proteomics

Gespeichert in:
Bibliographische Detailangaben
Titel: Neuropsychiatric symptoms in cognitive decline and Alzheimer’s disease: biomarker discovery using plasma proteomics
Autoren: Rabl, Miriam, Clark, Christopher, Dayon, Loïc, Popp, Julius
Weitere Verfasser: Alzheimer's Disease Neuroimaging Initiative, Weiner, M., Aisen, P., Jack, C.R., Jagust, W., Landau, S., Rivera-Mindt, M., Okonkwo, O., Shaw, L.M., Lee, E.B., Toga, A.W., Beckett, L., Harvey, D., Green, R.C., Saykin, A.J., Nho, K., Perrin, R.J., Tosun, D., Sachdev, P., Drake, E., Montine, T., Conti, C., Nosheny, R., Sacrey, D., Fockler, J., Miller, M.J., Kwang, W., Jin, C., Diaz, A., Ashford, M., Flenniken, D., Kormos, A., Rafii, M., Raman, R., Jimenez, G., Donohue, M., Salazar, J., Fidell, A., Boatwright, V., Robison, J., Zimmerman, C., Cabrera, Y., Walter, S., Clanton, T., Shaffer, E., Webb, C., Hergesheimer, L., Smith, S., Ogwang, S., Mahboubi, P., Pizzola, J., Jenkins, C., Saito, N., Hussen, K., Amaza, H., Thao, M., Parkins, S., Ayo, O., Glittenberg, M., Hoang, I., Germano, K., Strong, J., Weisensel, T., Magana, F., Thomas, L., Guzman, V., Ajayi, A., Benedetto, J., Talavera, S., Felmlee, J., Fox, N.C., Thompson, P., DeCarli, C., Forghanian-Arani, A., Borowski, B., Reyes, C., Hedberg, C., Ward, C., Schwarz, C., Reyes, D., Gunter, J., Moore-Weiss, J., Kantarci, K., Matoush, L., Senjem, M., Vemuri, P., Reid, R., Malone, I., Thomopoulos, S.I., Nir, T.M., Jahanshad, N., Knaack, A., Fletcher, E., Tosun-Turgut, D., Chen, S., Choe, M., Crawford, K., Yushkevich, P.A., Das, S., Koepp, R.A., Rabinovici, G., Villemagne, V., LoPresti, B., Morris, J., Franklin, E., Bernhardt, H., Cairns, N.J., Taylor-Reinwald, L., Lee, V.M., Korecka, M., Brylska, M., Wan, Y., Trojanowki, J.Q., Neu, S., Foroud, T.M., Jo, T., Risacher, S.L., Craft, H., Apostolova, L.G., Nudelman, K., Faber, K., Potter, Z., Lacy, K., Kaddurah-Daouk, R., Shen, L., Karlawish, J., Erickson, C., Grill, J., Largent, E., Harkins, K., Thal, L., Kachaturian, Z., Frank, R., Snyder, P.J., Buckholtz, N., Hsiao, J.K., Ryan, L., Molchan, S., Carrillo, M., Potter, W., Barnes, L., Bernard, M., González, H., Ho, C., Jackson, J., Masliah, E., Masterman, D., Silverberg, N., Silbert, L., Kaye, J., White, S., Pierce, A., Thomas, A., Clay, T., Schwartz, D., Devereux, G., Taylor, J., Ryan, J., Nguyen, M., DeCapo, M., Shang, Y., Schneider, L., Munoz, C., Ferman, D., Conant, C., Martin, K., Oleary, K., Pawluczyk, S., Trejo, E., Dagerman, K., Teodoro, L., Becerra, M., Fairooz, M., Garrison, S., Boudreau, J., Avila, Y., Brewer, J., Jacobson, A., Gama, A., Kim, C., Little, E., Frascino, J., Ferng, N., Trujillo, S., Heidebrink, J., Koeppe, R., MacDonald, S., Malyarenko, D., Ziolkowski, J., O'Connor, J., Robert, N., Lowe, S., Rogers, V., Hackenmiller, B., Boeve, B., Albers, C., Kreuger, C., Jones, D., Knopman, D., Botha, H., Magnuson, J., Graff-Radford, J., Crawley, K., Schumacher, M., McKinzie, S., Helland, T., Lowe, V., Ramanan, V., Pavlik, V., Faircloth, J., Bishop, J., Nath, J., Chaudhary, M., Kataki, M., Yu, M., Pacini, N., Barker, R., Brooks, R., Aggarwal, R., Honig, L., Stern, Y., Mintz, A., Cordona, J., Hernandez, M., Long, J., Arnold, A., Groves, A., Middleton, A., Vogler, B., McCurry, C., Mayo, C., Raji, C., Amtashar, F.S., Klemp, H., Elmore, H., Ruszkiewicz, J., Kusuran, J., Stewart, J., Horenkamp, J., Greeson, J., Wever, K., Vo, K., Larkin, K., Rao, L., Schoolcraft, L., Gallagher, L., Paczynski, M., McMillan, M., Holt, M., Gagliano, N., Henson, R., LaBarge, R., Swarm, R., Munie, S., Cepeda, S., Winterton, S., Hegedus, S., Wilson, T., Harte, T., Bonacorsi, Z., Geldmacher, D., Watkins, A., Barger, B., Smelser, B., Bates, C., Stover, C., McKinley, E., Ikner, G., Hendrix, H., Cooper, H., Mahaffey, J., Robbins, L., Ashley, L., Natelson-Love, M., Carter, P., Solomon, V., Grossman, H., Groome, A., Ardolino, A., Kaplan, A., Sheppard, F., Burgos-Rivera, G., Garcia-Camilo, G., Lim, J., Neugroschl, J., Jackson, K., Evans, K., Soleimani, L., Sano, M., Ghesani, N., Binder, S., Apuango, X., Sood, A., Troutman, A., Blanchard, K., Richards, A., Nelson, G., Hendrickson, K., Yurko, E., Plenge, J., Rufo, V., Shah, R., Duara, R., Lynch, B., Chirinos, C., Dittrich, C., Campbell, D., Mejia, D., Perez, G., Colvee, H., Gonzalez, J., Gondrez, J., Knaack, J., Acevedo, M., Cereijo, M., Greig-Cust, M., Villar, M., Wishnia, M., Detling, S., Barker, W., Albert, M., Moghekar, A., Rodzon, B., Demsky, C., Pontone, G., Pekar, J., Farrington, L., Pomper, M., Johnson, N., Alo, T., Sadowski, M., Ulysse, A., Masurkar, A., Marti, B., Mossa, D., Geesey, E., Petrocca, E., Schulze, E., Wong, J., Boonsiri, J., Kenowsky, S., Martinez, T., Briglall, V., Murali Doraiswamy, P., Nwosu, A., Adhikari, A., Hellegers, C., Petrella, J., James, O., Wong, T., Hawk, T., Vaishnavi, S., McCoubrey, H., Nasrallah, I., Rovere, R., Maneval, J., Robinson, E., Rivera, F., Uffelman, J., Combs, M., O'Donnell, P., Manning, S., King, R., Nieto, A., Glueck, A., Mandal, A., Swain, A., Gamble, B., Meacham, B., Forenback, D., Ross, D., Cheatham, E., Hartman, E., Cornell, G., Harp, J., Ashe, L., Goins, L., Watts, L., Yazell, M., Mandal, P., Buckler, R., Vincent, S., Rudd, T., Lopez, O., Malia, A., Chiado, C., Zik, C., Savage, K., Fenice, L., Oakley, M., Tacey, P., Berman, S., Bowser, S., Saganis, X., Porsteinsson, A., Mathewson, A., Widman, A., Holvey, B., Clark, E., Morales, E., Young, I., Hopkins, K., Kowalski, N., Hunt, R., Calzavara, R., Kurvach, R., D'Ambrosio, S., Thai, G., Vides, B., Lieb, B., McAdams-Ortiz, C., Toso, C., Mares, I., Moorlach, K., Liu, L., Corona, M., Tallakson, M., McDonnell, M., Rangel, M., Basheer, N., Place, P., Romero, R., Tam, S., Nguyen, T., Frolov, A., Khera, A., Browning, A., Kelley, B., Dawson, C., Mathews, D., Most, E., Phillips, E., Nguyen, L., Nunez, M., Miller, M., Jones, M.R., Martinez, N., Logan, R., McColl, R., Pham, S., Fox, T., Moore, T., Levey, A., Brown, A., Kippels, A., Ellison, A., Lyons, C., Hales, C., Parry, C., Williams, C., McCorkle, E., Harris, G., Rose, H., Jooma, I., Al-Amin, J., Lah, J., Webster, J., Swiniarski, J., Chapman, L., Donnelly, L., Mariotti, L., Locke, M., Vaughn, P., Penn, R., Carpentier, S., Yeboah, S., Basadre, S., Malakauskas, S., Lyron, S., Villinger, T., Burney, T., Burns, J., Abusalim, A., Dahlgren, A., Montero, A., Arthur, A., Dooly, H., Kreszyn, K., Berner, K., Gillen, L., Scanlan, M., Madison, M., Mathis, N., Switzer, P., Townley, R., Fikru, S., Sullivan, S., Wright, E., Beigi, M., Daley, A., Ko, A., Luong, B., Nyborg, G., Morales, J., Durbin, K., Garcia, L., Parand, L., Macias, L., Monserratt, L., Farchi, M., Wu, P., Hernandez, R., Rodriguez, T., Graff-Radford, N., Marolt, A., Aloszka, D., Moncayo, E., Westerhold, E., Day, G., Chrestensen, K., Imhansiemhonehi, M., Stephens, S., Grant, S., Brosch, J., Perkins, A., Saunders, A., Kovac, D., Polson, H., Mwaura, I., Mejia, K., Britt, K., King, K., Nichols, K., Lawrence, K., Rankin, L., Farlow, M., Wiesenauer, P., Bryant, R., Herring, S., Lynch, S., Wilson, S., Day, T., Korst, W., Dyck, C., Mecca, A., Miller, A., Brennan, A., Khan, A., Ruan, A., Gunnoud, C., Mendonca, C., Raynes-Goldfinger, D., Salardini, E., Hidalgo, E., Cooper, E., Singh, E., Murphy, E., May, J., Stanhope, J., Lam, J., Waszak, J., Nelsen, K., Sacaza, K., Hasbani, M., Donahue, M., Chen, M.K., Barcelos, N., Eigenberger, P., Bonomi, R., O'Dell, R., Jefferson, S., Khasnavis, S., Smilowitz, S., DeStefano, S., Good, S., Camarro, T., Clayton, V., Cavrel, Y., Lu, Y., Chertkow, H., Bergman, H., Hosein, C., Black, S., Kapadia, A., Bhan, A., Lam, B., Scott, C., Gabriel, G., Bray, J., Zotovic, L., Gutierrez, M., Masellis, M., Farshadi, M., Gui, M., Mitchell, M., Taylor, R., Endre, R., Taghi-Zada, Z., Hsiung, R., English, C., Kim, E., Yau, E., Tong, H., Barlow, L., Jennings, L., Assaly, M., Nunes, P., Marian, T., Kertesz, A., Rogers, J., Trost, D., Wint, D., Bernick, C., Munic, D., Grant, I., Korkoyah, A., Raja, A., Lapins, A., Ryan, C., Pejic, J., Basham, K., Lukose, L., Haddad, L., Quinlan, L., Houghtaling, N., Sadowsky, C., Martinez, W., Villena, T., Reynolds, B., Forero, A., Brennan, E., Figueroa, E., Esposito, G., Mallory, J., Johnson, K., Turner, K., Seidenberg, K., McCann, K., Bassett, M., Chadwick, M., Turner, R., Bean, R., Sharma, S., Marshall, G., Haviari, A., Pietras, A., Wallace, B., Munro, C., Rivera-Delpin, G., Hustead, H., Levesque, I., Ramirez, J., Nolan, K., Glennon, K., Palou, M., Erkkinen, M., DaSilva, N., Friedman, P., Silver, R.M., Salazar, R., Polleys, R., McGinnis, S., Gale, S., Hall, T., Luu, T., Chao, S., Lin, E., Coleman, J., Epperson, K., Vasanawala, M., Atri, A., Rangel, A., Evans, B., Monarrez, C., Cline, C., Liebsack, C., Bandy, D., Goldfarb, D., Intorcia, D., Olgin, J., Clark, K., York, K., Reade, M., Callan, M., Glass, M., Johnson, M., Goddard, M., Trncic, N., Choudhury, P., Reyes, P., Lowery, S., Hall, S., Olgin, S., Santiago, S., Alosco, M., Ton, A., Jimenez, A., Tran, A., Anderson, B., Carter, D., Veronelli, D., Lenio, S., Steinberg, E., Mez, J., Weller, J., Johns, J., Harkins, J., Hoti, I., Mwicigi, J., Schultz, O., Lauture, M., Denis, R., Killiany, R., Singh, S., Qiu, W., Devis, Y., Obisesan, T., Stone, A., Ordor, D., Udodong, I., Okonkwo, I., Khan, J., Turner, J., Hughes, K., Kadiri, O., Duffy, C., Moss, A., Stapleton, K., Toth, M., Sanders, M., Ayres, M., Hamski, M., Fatica, P., Ogrocki, P., Ash, S., Pot, S., Chen, D., Soto, A., Tanase, C., Bissig, D., Vanya, H., Russell, H., Patel, H., Zhang, H., Wallace, K., Ayers, K., Gallegos, M., Forloines, M., Sinn, M., Kahulugan, Q., Isip, R., Calderon, S., Hamm, T., Borrie, M., Lee, T.Y., Bartha, R., Johnson, S., Asthana, S., Carlsson, C.M., Perrin, A., Tariot, P., Fleisher, A., Reeder, S., Capote, H., Emborsky, A., Mattle, A., Ajtai, B., Wagner, B., Myers, B., Slazyk, D., Fragale, D., Fransen, E., Macnamara, H., Falletta, J., Hirtreiter, J., Mechtler, L., King, M., Asbach, M., Rainka, M., Zawislak, R., Wisniewski, S., O'Malley, S., Jimenez-Knight, T., Peehler, T., Aladeen, T., Bates, V., Wenner, V., Elmalik, W., Scharre, D.W., Ramamurthy, A., Bouchachi, S., Tarawneh, R., Celmins, D., Leader, A., Figueroa, C., Bauerle, H., Patterson, K., Reposa, M., Presto, S., Ahmed, T., Stewart, W., Pearlson, G.D., Blank, K., Anderson, K., Santulli, R.B., Schwartz, E.S., Williamson, J., Jessup, A., Williams, A., Duncan, C., O'Connell, A., Gagnon, K., Zamora, E., Bateman, J., Crawford, F., Thompson, D., Walker, E., Rowell, J., White, M., Ledford, P., Bohlman, S., Henkle, S., Bottoms, J., Moretz, L., Hoover, B., Shannon, M., Rogers, S., Baker, W., Harrison, W., Wu, C.K., DeMarco, A., Stipanovich, A., Arcuri, D., Clark, J., Davis, J., Doyon, K., Amoyaw, M., Acosta, M., Bailey, R., Warren, S., Fogerty, T., Sanborn, V., Riddle, M., Salloway, S., Malloy, P., Correia, S., Windon, C., Blackburn, M., Rosen, H.J., Miller, B.L., Smith, A., Mba, I., Echevarria, J., Janavs, J., Roglaski, E., Yong, M., Devine, R., Okhravi, H., Rivera, E., Kalowsky, T., Smith, C., Rosario, C., Masdeu, J., Le, R., Gurung, M., Sabbagh, M., Garcia, A., Slaughter, M., Elayan, N., Acothley, S., Pomara, N., Hernando, R., Pomara, V., Reichert, C., Brawman-Mintzer, O., Acree, A., Long, C., Long, R., Newhouse, P., Hill, S., Boegel, A., Seshadri, S., Saklad, A., Jones, F., Hu, W., Sotelo, V., Rojas, Y., Mintzer, J., Longmire, C., Spicer, K., University of Zurich, Popp, Julius
Quelle: J Neurol Neurosurg Psychiatry
Journal of neurology, neurosurgery, and psychiatry, vol. 96, no. 4, pp. 370-382
Verlagsinformationen: BMJ, 2024.
Publikationsjahr: 2024
Schlagwörter: 2738 Psychiatry and Mental Health, 2728 Neurology (clinical), 10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics, 610 Medicine & health, Neuropsychiatry, 2746 Surgery, Humans, Alzheimer Disease/blood, Biomarkers/blood, Biomarkers/cerebrospinal fluid, Male, Female, Cognitive Dysfunction/blood, Cognitive Dysfunction/cerebrospinal fluid, Aged, Proteomics, Disease Progression, Neuropsychological Tests, Aged, 80 and over, Blood Proteins/analysis, ALZHEIMER'S DISEASE, APATHY, BEHAVIOURAL DISORDER, DEPRESSION, MOLECULAR BIOLOGY
Beschreibung: Background and objectivesNeuropsychiatric symptoms (NPS) are common in older people with cognitive impairment and Alzheimer’s disease (AD). No biomarkers to detect the related pathology or predict the clinical evolution of NPS are available yet. This study aimed to identify plasma proteins that may serve as biomarkers for NPS and NPS-related clinical disease progression.MethodsA panel of 190 plasma proteins was quantified using Luminex xMAP in the Alzheimer’s Disease Neuroimaging Initiative cohort. NPS and cognitive performance were assessed at baseline and after 1 and 2 years. Logistic regression, receiver operating characteristic analysis and cross-validation were used to address the relations of interest.ResultsA total of 507 participants with mild cognitive impairment (n=396) or mild AD dementia (n=111) were considered. Selected plasma proteins improved the prediction of NPS (area under the curve (AUC) from 0.61 to 0.76, pConclusionsPlasma proteins are associated with NPS and improve prediction of future NPS.
Publikationsart: Article
Other literature type
Dateibeschreibung: application/pdf; ZORA_279058.pdf - application/pdf
Sprache: English
ISSN: 1468-330X
0022-3050
DOI: 10.1136/jnnp-2024-333819
DOI: 10.5167/uzh-279058
Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/39288961
https://serval.unil.ch/resource/serval:BIB_D8FFCBBF9B53.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_D8FFCBBF9B535
https://serval.unil.ch/notice/serval:BIB_D8FFCBBF9B53
Rights: CC BY NC
Dokumentencode: edsair.doi.dedup.....8d9cbb85f11413bf1524fbefeddb9ca7
Datenbank: OpenAIRE
Beschreibung
Abstract:Background and objectivesNeuropsychiatric symptoms (NPS) are common in older people with cognitive impairment and Alzheimer’s disease (AD). No biomarkers to detect the related pathology or predict the clinical evolution of NPS are available yet. This study aimed to identify plasma proteins that may serve as biomarkers for NPS and NPS-related clinical disease progression.MethodsA panel of 190 plasma proteins was quantified using Luminex xMAP in the Alzheimer’s Disease Neuroimaging Initiative cohort. NPS and cognitive performance were assessed at baseline and after 1 and 2 years. Logistic regression, receiver operating characteristic analysis and cross-validation were used to address the relations of interest.ResultsA total of 507 participants with mild cognitive impairment (n=396) or mild AD dementia (n=111) were considered. Selected plasma proteins improved the prediction of NPS (area under the curve (AUC) from 0.61 to 0.76, pConclusionsPlasma proteins are associated with NPS and improve prediction of future NPS.
ISSN:1468330X
00223050
DOI:10.1136/jnnp-2024-333819