Convergent and Discriminant Validity of Default Mode Network and Limbic Network Perfusion in Amnestic Mild Cognitive Impairment Patients
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| Názov: | Convergent and Discriminant Validity of Default Mode Network and Limbic Network Perfusion in Amnestic Mild Cognitive Impairment Patients |
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| Autori: | Quattrini, Giulia, Marizzoni, Moira, Pizzini, Francesca B, Galazzo, Ilaria Boscolo, Aiello, Marco, Didic, Mira, Soricelli, Andrea, Albani, Diego, Romano, Melissa, Blin, Olivier, Forloni, Gianluigi, Golay, Xavier, Jovicich, Jorge, Nathan, Pradeep J, Richardson, Jill C, Salvatore, Marco, Frisoni, Giovanni, Pievani, Michela, PharmaCog Consortium |
| Prispievatelia: | Otten, Lisa |
| Zdroj: | Journal of Alzheimer's Disease. 82:1797-1808 |
| Informácie o vydavateľovi: | SAGE Publications, 2021. |
| Rok vydania: | 2021 |
| Predmety: | Male, Arterial spin labeling, Cognitive Dysfunction / physiopathology, Hippocampus, Alzheimer's disease, arterial spin labeling, brain perfusion, default mode network, limbic network, mild cognitive impairment, 618.97, 03 medical and health sciences, 0302 clinical medicine, Brain perfusion, Alzheimer Disease, Limbic network, Limbic System, Humans, Cognitive Dysfunction, 10. No inequality, Alzheimer Disease / physiopathology, Aged, Amnesia, Biomarkers, Cerebrovascular Circulation, Female, Magnetic Resonance Imaging, Default Mode Network, Perfusion, 2. Zero hunger, [SCCO.NEUR] Cognitive science/Neuroscience, Mild cognitive impairment, Hippocampus / physiopathology, 3. Good health, Amnesia / physiopathology, Default mode network, Biomarkers / cerebrospinal fluid |
| Popis: | Background: Previous studies reported default mode network (DMN) and limbic network (LIN) brain perfusion deficits in patients with amnestic mild cognitive impairment (aMCI), frequently a prodromal stage of Alzheimer’s disease (AD). However, the validity of these measures as AD markers has not yet been tested using MRI arterial spin labeling (ASL). Objective: To investigate the convergent and discriminant validity of DMN and LIN perfusion in aMCI. Methods: We collected core AD markers (amyloid-β 42 [Aβ42], phosphorylated tau 181 levels in cerebrospinal fluid [CSF]), neurodegenerative (hippocampal volumes and CSF total tau), vascular (white matter hyperintensities), genetic (apolipoprotein E [APOE] status), and cognitive features (memory functioning on Paired Associate Learning test [PAL]) in 14 aMCI patients. Cerebral blood flow (CBF) was extracted from DMN and LIN using ASL and correlated with AD features to assess convergent validity. Discriminant validity was assessed carrying out the same analysis with AD-unrelated features, i.e., somatomotor and visual networks’ perfusion, cerebellar volume, and processing speed. Results: Perfusion was reduced in the DMN (F = 5.486, p = 0.039) and LIN (F = 12.678, p = 0.004) in APOE ɛ4 carriers compared to non-carriers. LIN perfusion correlated with CSF Aβ42 levels (r = 0.678, p = 0.022) and memory impairment (PAL, number of errors, r = –0.779, p = 0.002). No significant correlation was detected with tau, neurodegeneration, and vascular features, nor with AD-unrelated features. Conclusion: Our results support the validity of DMN and LIN ASL perfusion as AD markers in aMCI, indicating a significant correlation between CBF and amyloidosis, APOE ɛ4, and memory impairment. |
| Druh dokumentu: | Article |
| Popis súboru: | application/pdf |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-210531 |
| Prístupová URL adresa: | https://hal.archives-ouvertes.fr/hal-03575102/file/draft_Quattrini_RR2_JAD_2021_DEF.pdf https://pubmed.ncbi.nlm.nih.gov/34219733 https://pubmed.ncbi.nlm.nih.gov/34219733/ https://iris.univr.it/handle/11562/1045759 https://content.iospress.com/articles/journal-of-alzheimers-disease/jad210531 https://www.ncbi.nlm.nih.gov/pubmed/34219733 https://archive-ouverte.unige.ch/unige:169177 https://doi.org/10.3233/jad-210531 https://hal.science/hal-03575102v1/document https://doi.org/10.3233/jad-210531 https://hal.science/hal-03575102v1 https://discovery-pp.ucl.ac.uk/id/eprint/10131190/ |
| Prístupové číslo: | edsair.doi.dedup.....8c11a3036f24bd4f748e48b1686d231e |
| Databáza: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | Background: Previous studies reported default mode network (DMN) and limbic network (LIN) brain perfusion deficits in patients with amnestic mild cognitive impairment (aMCI), frequently a prodromal stage of Alzheimer’s disease (AD). However, the validity of these measures as AD markers has not yet been tested using MRI arterial spin labeling (ASL). Objective: To investigate the convergent and discriminant validity of DMN and LIN perfusion in aMCI. Methods: We collected core AD markers (amyloid-β 42 [Aβ42], phosphorylated tau 181 levels in cerebrospinal fluid [CSF]), neurodegenerative (hippocampal volumes and CSF total tau), vascular (white matter hyperintensities), genetic (apolipoprotein E [APOE] status), and cognitive features (memory functioning on Paired Associate Learning test [PAL]) in 14 aMCI patients. Cerebral blood flow (CBF) was extracted from DMN and LIN using ASL and correlated with AD features to assess convergent validity. Discriminant validity was assessed carrying out the same analysis with AD-unrelated features, i.e., somatomotor and visual networks’ perfusion, cerebellar volume, and processing speed. Results: Perfusion was reduced in the DMN (F = 5.486, p = 0.039) and LIN (F = 12.678, p = 0.004) in APOE ɛ4 carriers compared to non-carriers. LIN perfusion correlated with CSF Aβ42 levels (r = 0.678, p = 0.022) and memory impairment (PAL, number of errors, r = –0.779, p = 0.002). No significant correlation was detected with tau, neurodegeneration, and vascular features, nor with AD-unrelated features. Conclusion: Our results support the validity of DMN and LIN ASL perfusion as AD markers in aMCI, indicating a significant correlation between CBF and amyloidosis, APOE ɛ4, and memory impairment. |
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| ISSN: | 18758908 13872877 |
| DOI: | 10.3233/jad-210531 |