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Treatment-related mortality among children with cancer in Denmark during 2001-2021

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Titel: Treatment-related mortality among children with cancer in Denmark during 2001-2021
Autoren: Marie C.L. Sørensen, Mie M. Andersen, Klaus Rostgaard, Kjeld Schmiegelow, Torben S. Mikkelsen, Peder S. Wehner, Marianne Olsen, Signe H. Søegaard, Lisa L. Hjalgrim
Quelle: Acta Oncol
Acta Oncologica, Vol 63, Iss 1 (2024)
Sørensen, M C L, Andersen, M M, Rostgaard, K, Schmiegelow, K, Mikkelsen, T S, Wehner, P S, Olsen, M, Søegaard, S H & Hjalgrim, L L 2024, 'Treatment-related mortality among children with cancer in Denmark during 2001-2021', Acta Oncologica, vol. 63, pp. 294-302. https://doi.org/10.2340/1651-226X.2024.27731
Sørensen, M C L, Andersen, M M, Rostgaard, K, Schmiegelow, K, Mikkelsen, T S, Wehner, P S, Olsen, M, Søegaard, S H & Hjalgrim, L L 2024, ' Treatment-related mortality among children with cancer in Denmark during 2001-2021 ', Acta oncologica (Stockholm, Sweden), vol. 63, pp. 294-302 . https://doi.org/10.2340/1651-226X.2024.27731
Verlagsinformationen: MJS Publishing, Medical Journals Sweden AB, 2024.
Publikationsjahr: 2024
Schlagwörter: Male, 0301 basic medicine, Register-based study, Treatment-related death, Adolescent, Denmark, Paediatric cancer, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Neoplasms, Original Report, Humans, Registries, Child, RC254-282, Retrospective Studies, Incidence, Registries/statistics & numerical data, Infant, Newborn, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Infant, Denmark/epidemiology, 3. Good health, Child, Preschool, Female, Neoplasms/mortality, Cohort study
Beschreibung: Background: Survival of children with cancer has markedly improved over recent decades, largely due to intensified treatment regimes. The intensive treatment may, however, result in fatal complications. In this retrospective cohort study, we assessed temporal variation in the incidence of treatment-related death and associated risk factors among children diagnosed with cancer in Denmark during 2001–2021. Method: Among all children diagnosed with first incident cancer before age 15 years recorded in the Danish Childhood Cancer Register (n = 3,255), we estimated cumulative incidence of treatment-related death (death in the absence of progressive cancer) within 5 years from diagnosis using Aalen–Johansen estimators and assessed associated risk factors using Cox regression. Results: Among all 3,255 children with cancer, 93 (20% of all 459 deaths) died from treatment. Of these treatment-related deaths, 39 (42%) occurred within 3 months of diagnosis. The 5-year cumulative incidences of treatment-related death were 3.3% during 2001–2010 and 2.5% during 2011–2021 (p = 0.20). During 2011–2021, treatment-related deaths accounted for more than half of all deaths among children with haematological cancers. Risk factors varied according to cancer group and included female sex, age below 1 year at diagnosis, disease relapse, stem cell transplantation, central nervous system involvement, and metastasis at diagnosis. Interpretation: Despite increasing treatment intensities, the incidence of treatment-related death has remained stable during the past 20 years in Denmark. Still, clinical attention is warranted to prevent treatment-related deaths, particularly among children with haematological cancers. Patient characteristics associated with increased treatment-related death risk support patient-specific treatment approaches to avoid these fatalities.
Publikationsart: Article
Other literature type
Dateibeschreibung: application/pdf
ISSN: 1651-226X
0284-186X
DOI: 10.2340/1651-226x.2024.27731
Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/38716484
https://doaj.org/article/17276a5b55aa46d7b47a219ead167085
https://vbn.aau.dk/da/publications/c027eede-2553-4fdc-a30f-234b2e3341b9
https://doi.org/10.2340/1651-226X.2024.27731
https://vbn.aau.dk/ws/files/713755897/S_rensen_et_al._2024_._Treatment-related_mortality_among_children_with_cancer_in_Denmark_during_2001-2021.pdf
https://curis.ku.dk/ws/files/392450781/AO27731.pdf
https://portal.findresearcher.sdu.dk/da/publications/d19b20d7-8f29-432f-a966-97b3ed6ec7d6
https://doi.org/10.2340/1651-226X.2024.27731
https://pure.au.dk/portal/en/publications/e0fa9cdf-d256-431a-a8a6-8a568dcd7cd4
https://doi.org/10.2340/1651-226X.2024.27731
Rights: CC BY
URL: http://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, with the condition of proper attribution to the original work.
Dokumentencode: edsair.doi.dedup.....8bea17223b5f37bee29cb5152b15e3d7
Datenbank: OpenAIRE
Beschreibung
Abstract:Background: Survival of children with cancer has markedly improved over recent decades, largely due to intensified treatment regimes. The intensive treatment may, however, result in fatal complications. In this retrospective cohort study, we assessed temporal variation in the incidence of treatment-related death and associated risk factors among children diagnosed with cancer in Denmark during 2001–2021. Method: Among all children diagnosed with first incident cancer before age 15 years recorded in the Danish Childhood Cancer Register (n = 3,255), we estimated cumulative incidence of treatment-related death (death in the absence of progressive cancer) within 5 years from diagnosis using Aalen–Johansen estimators and assessed associated risk factors using Cox regression. Results: Among all 3,255 children with cancer, 93 (20% of all 459 deaths) died from treatment. Of these treatment-related deaths, 39 (42%) occurred within 3 months of diagnosis. The 5-year cumulative incidences of treatment-related death were 3.3% during 2001–2010 and 2.5% during 2011–2021 (p = 0.20). During 2011–2021, treatment-related deaths accounted for more than half of all deaths among children with haematological cancers. Risk factors varied according to cancer group and included female sex, age below 1 year at diagnosis, disease relapse, stem cell transplantation, central nervous system involvement, and metastasis at diagnosis. Interpretation: Despite increasing treatment intensities, the incidence of treatment-related death has remained stable during the past 20 years in Denmark. Still, clinical attention is warranted to prevent treatment-related deaths, particularly among children with haematological cancers. Patient characteristics associated with increased treatment-related death risk support patient-specific treatment approaches to avoid these fatalities.
ISSN:1651226X
0284186X
DOI:10.2340/1651-226x.2024.27731