REM-predominant obstructive sleep apnea: an unmet clinical need: an unmet clinical need
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| Titel: | REM-predominant obstructive sleep apnea: an unmet clinical need: an unmet clinical need |
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| Autoren: | Shauni Wellekens, Eef Vanderhelst, Sylvia Verbanck, Sonia De Weerdt |
| Weitere Verfasser: | Brussels Photonics, Pneumology, Physiotherapy, Human Physiology and Anatomy, Vitality Research Group, Clinical sciences |
| Quelle: | Sleep and Breathing. 29 |
| Verlagsinformationen: | Springer Science and Business Media LLC, 2025. |
| Publikationsjahr: | 2025 |
| Schlagwörter: | Male, Adult, Sleep Apnea, Obstructive, Sleep, REM/physiology, Depression, Depression/epidemiology, Polysomnography, Sleep, REM, Disorders of Excessive Somnolence/epidemiology, Disorders of Excessive Somnolence, Fatigue/epidemiology, Middle Aged, polysomnography, Humans, Female, Sleep Apnea, Obstructive/epidemiology, Fatigue, Aged |
| Beschreibung: | Obstructive sleep apnea (OSA) and rapid eye movement (REM) sleep fragmentation are associated with increased fatigue, sleepiness, anxiety and depressive symptoms. However, the clinical significance of REM-predominant OSA (REM-OSA) remains less clear.To determine any differences in symptom-burden between REM-OSA and non-REM (NREM) OSA.Patients diagnosed with OSA at a University Hospital in Brussels between 25-11-2019 and 19-09-2020 were eligible. REM-OSA was defined as an apnea hypopnea index REM/NREM ratio of at least 2 with a minimum REM-time of 30 min. Severe OSA was excluded due to the expectedly lower prevalence of REM-OSA in this group. All patients completed the Hospital Anxiety and Depression Scale, Big Five Inventory-2, DS-14 questionnaire, SF-36 Health Survey Questionnaire, Pittsburgh Sleep Quality Index, Insomnia Severity Index, Fatigue Assessment Scale, Checklist Individual Strength, Epworth Sleepiness Scale and Stanford Sleepiness Scale at diagnosis.209 patients with REM-OSA (112 mild and 97 moderate) and 132 with NREM-OSA (48 mild and 84 moderate) were included. Patients with mild REM-OSA were twice as likely to have a SSS score of 3 or more (defined as excessive daytime sleepiness) compared to NREM-OSA (odds ratio 2.1591, p-value 0.0359). There was no significant difference in anxiety, depression, personality traits, fatigue or sleep quality.For mild OSA, a predominance of obstructive respiratory events during the REM phase results in a greater impact on excessive daytime sleepiness. To address this symptom, a lower treatment threshold to include symptomatic mild REM-OSA patients may be warranted. |
| Publikationsart: | Article |
| Sprache: | English |
| ISSN: | 1522-1709 1520-9512 |
| DOI: | 10.1007/s11325-025-03268-5 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/39934482 https://hdl.handle.net/20.500.14017/3d2b6776-485e-45e9-82d0-7aff660740e4 https://doi.org/10.1007/s11325-025-03268-5 https://biblio.vub.ac.be/vubir/(3d2b6776-485e-45e9-82d0-7aff660740e4).html |
| Rights: | Springer Nature TDM |
| Dokumentencode: | edsair.doi.dedup.....8be009cea652511454e8e930deb0ff82 |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Obstructive sleep apnea (OSA) and rapid eye movement (REM) sleep fragmentation are associated with increased fatigue, sleepiness, anxiety and depressive symptoms. However, the clinical significance of REM-predominant OSA (REM-OSA) remains less clear.To determine any differences in symptom-burden between REM-OSA and non-REM (NREM) OSA.Patients diagnosed with OSA at a University Hospital in Brussels between 25-11-2019 and 19-09-2020 were eligible. REM-OSA was defined as an apnea hypopnea index REM/NREM ratio of at least 2 with a minimum REM-time of 30 min. Severe OSA was excluded due to the expectedly lower prevalence of REM-OSA in this group. All patients completed the Hospital Anxiety and Depression Scale, Big Five Inventory-2, DS-14 questionnaire, SF-36 Health Survey Questionnaire, Pittsburgh Sleep Quality Index, Insomnia Severity Index, Fatigue Assessment Scale, Checklist Individual Strength, Epworth Sleepiness Scale and Stanford Sleepiness Scale at diagnosis.209 patients with REM-OSA (112 mild and 97 moderate) and 132 with NREM-OSA (48 mild and 84 moderate) were included. Patients with mild REM-OSA were twice as likely to have a SSS score of 3 or more (defined as excessive daytime sleepiness) compared to NREM-OSA (odds ratio 2.1591, p-value 0.0359). There was no significant difference in anxiety, depression, personality traits, fatigue or sleep quality.For mild OSA, a predominance of obstructive respiratory events during the REM phase results in a greater impact on excessive daytime sleepiness. To address this symptom, a lower treatment threshold to include symptomatic mild REM-OSA patients may be warranted. |
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| ISSN: | 15221709 15209512 |
| DOI: | 10.1007/s11325-025-03268-5 |