Place and Underlying Cause of Death During the COVID-19 Pandemic: Retrospective Cohort Study of 3.5 Million Deaths in England and Wales, 2014 to 2020: Retrospective Cohort Study of 3.5 Million Deaths in England and Wales, 2014 to 2020
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| Titel: | Place and Underlying Cause of Death During the COVID-19 Pandemic: Retrospective Cohort Study of 3.5 Million Deaths in England and Wales, 2014 to 2020: Retrospective Cohort Study of 3.5 Million Deaths in England and Wales, 2014 to 2020 |
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| Autoren: | Chris P Gale, M Mafham, Muhammad Rashid, Evangelos Kontopantelis, John E. Deanfield, Mark A de Belder, Mamas A. Mamas, Jianhua Wu |
| Quelle: | Mayo Clin Proc Wu, J, Mafham, M, Mamas, M A, Rashid, M, Kontopantelis, E, Deanfield, J E, de Belder, M A & Gale, C P 2021, 'Place and Underlying Cause of Death During the COVID-19 Pandemic : Retrospective Cohort Study of 3.5 Million Deaths in England and Wales, 2014 to 2020', Mayo Clinic Proceedings, vol. 96, no. 4, pp. 952-963. https://doi.org/10.1016/j.mayocp.2021.02.007 |
| Publication Status: | Preprint |
| Verlagsinformationen: | Elsevier BV, 2020. |
| Publikationsjahr: | 2020 |
| Schlagwörter: | Adult, Male, COVID-19/diagnosis, Heart Diseases, Diagnostic Errors/mortality, Nursing Homes/statistics & numerical data, Cause of Death/trends, 03 medical and health sciences, 0302 clinical medicine, RZ, Cause of Death, Neoplasms, 80 and over, Humans, Hospice Care/statistics & numerical data, Hospital Mortality, England/epidemiology, Diagnostic Errors, Mortality, Wales/epidemiology, Aged, Hospital Mortality/trends, Aged, 80 and over, Wales, SARS-CoV-2, Heart Diseases/mortality, R735, COVID-19, Middle Aged, Home Care Services, Nursing Homes, 3. Good health, Hospice Care, England, Home Care Services/statistics & numerical data, Original Article, Female, Neoplasms/mortality, RA |
| Beschreibung: | BackgroundThe COVID-19 pandemic has resulted in a high death toll. We aimed to describe the place and cause of death during the COVID-19 pandemic.MethodsThis national death registry included all adult (aged ≥18 years) deaths in England and Wales between 1st January 2014 and 30th June 2020. Analyses were based upon ICD-10 codes corresponding to the underlying cause of death as stated on the Medical Certificate of Cause of Death. Daily deaths during COVID-19 pandemic were compared against the expected daily deaths estimated using Farrington surveillance algorithm for daily historical data between 2014 and 2020, by place and cause of death.FindingsBetween 2nd March and 30th June 2020, there was an excess mortality of 57,860 (a proportional increase of 35%) compared with the expected deaths, of which 50,603 (86.2%) were COVID-19 related. Almost half the excess deaths occurred in care homes (25,611 deaths) where deaths were 55% higher than expected. One fifth of the excess deaths occurred in hospital (15,938 deaths; a proportional increase of 21%) with the remainder occurring at home (16,190 deaths; a proportional increase of 39%). At home, only 14% of 16,190 excess deaths were related to COVID-19, with 5,963 deaths due to cancer and 2,485 deaths due to cardiac disease, very few of which involved COVID-19. In care homes or hospices, 61% of the 25,611 excess deaths were related to COVID-19, 5,539 of which were due to respiratory disease and most of these (4,315 deaths) involved COVID-19. In hospital, there were 16,174 fewer deaths than expected which did not involve COVID-19, and there were 4,088 fewer deaths due to cancer and 1,398 fewer deaths due to cardiac disease than expected.InterpretationThe COVID-19 pandemic has resulted in a substantial increase in the absolute numbers of deaths occurring at home and care homes. There was a huge burden of excess deaths occurring in care homes, which were poorly characterised, and were likely to be, at least in part, the result of undiagnosed COVID-19. There was a smaller but important and ongoing excess in deaths at home, particularly from cancer and cardiac disease, which suggests avoidance of hospital care for non-COVID-19 conditions.FundingThe study is unfunded. |
| Publikationsart: | Article Other literature type |
| Dateibeschreibung: | application/pdf |
| Sprache: | English |
| ISSN: | 0025-6196 |
| DOI: | 10.1016/j.mayocp.2021.02.007 |
| DOI: | 10.1101/2020.08.12.20173302 |
| Zugangs-URL: | http://www.mayoclinicproceedings.org/article/S0025619621001397/pdf https://eprints.keele.ac.uk/9484/1/Place%20and%20underlying%20cause%20of%20death%20during%20the%20COVID19%20pandemic.pdf https://pubmed.ncbi.nlm.nih.gov/33714592 https://research.manchester.ac.uk/en/publications/464384da-6ccc-4b9f-9a64-447343e73b1e https://doi.org/10.1016/j.mayocp.2021.02.007 https://www.medrxiv.org/content/10.1101/2020.08.12.20173302v1 http://www.medrxiv.org/content/10.1101/2020.08.12.20173302v1 https://medrxiv.org/content/10.1101/2020.08.12.20173302v1.full.pdf https://www.sciencedirect.com/science/article/abs/pii/S0025619621001397 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885692 https://pubmed.ncbi.nlm.nih.gov/33714592/ https://europepmc.org/article/PPR/PPR200768 https://www.research.manchester.ac.uk/portal/en/publications/place-and-underlying-cause-of-death-during-the-covid19-pandemic(464384da-6ccc-4b9f-9a64-447343e73b1e).html https://www.mayoclinicproceedings.org/article/S0025-6196(21)00139-7/fulltext https://research.manchester.ac.uk/en/publications/464384da-6ccc-4b9f-9a64-447343e73b1e https://discovery.ucl.ac.uk/id/eprint/10126433/ https://doi.org/10.1016/j.mayocp.2021.02.007 https://discovery-pp.ucl.ac.uk/id/eprint/10126433/ |
| Rights: | Elsevier TDM CC BY NC ND |
| Dokumentencode: | edsair.doi.dedup.....8ac1a8ddaa4e340e76c794b33783a00d |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | BackgroundThe COVID-19 pandemic has resulted in a high death toll. We aimed to describe the place and cause of death during the COVID-19 pandemic.MethodsThis national death registry included all adult (aged ≥18 years) deaths in England and Wales between 1st January 2014 and 30th June 2020. Analyses were based upon ICD-10 codes corresponding to the underlying cause of death as stated on the Medical Certificate of Cause of Death. Daily deaths during COVID-19 pandemic were compared against the expected daily deaths estimated using Farrington surveillance algorithm for daily historical data between 2014 and 2020, by place and cause of death.FindingsBetween 2nd March and 30th June 2020, there was an excess mortality of 57,860 (a proportional increase of 35%) compared with the expected deaths, of which 50,603 (86.2%) were COVID-19 related. Almost half the excess deaths occurred in care homes (25,611 deaths) where deaths were 55% higher than expected. One fifth of the excess deaths occurred in hospital (15,938 deaths; a proportional increase of 21%) with the remainder occurring at home (16,190 deaths; a proportional increase of 39%). At home, only 14% of 16,190 excess deaths were related to COVID-19, with 5,963 deaths due to cancer and 2,485 deaths due to cardiac disease, very few of which involved COVID-19. In care homes or hospices, 61% of the 25,611 excess deaths were related to COVID-19, 5,539 of which were due to respiratory disease and most of these (4,315 deaths) involved COVID-19. In hospital, there were 16,174 fewer deaths than expected which did not involve COVID-19, and there were 4,088 fewer deaths due to cancer and 1,398 fewer deaths due to cardiac disease than expected.InterpretationThe COVID-19 pandemic has resulted in a substantial increase in the absolute numbers of deaths occurring at home and care homes. There was a huge burden of excess deaths occurring in care homes, which were poorly characterised, and were likely to be, at least in part, the result of undiagnosed COVID-19. There was a smaller but important and ongoing excess in deaths at home, particularly from cancer and cardiac disease, which suggests avoidance of hospital care for non-COVID-19 conditions.FundingThe study is unfunded. |
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| ISSN: | 00256196 |
| DOI: | 10.1016/j.mayocp.2021.02.007 |