Copper death combination therapy: the innovative frontier and challenges in prostate cancer treatment
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| Titel: | Copper death combination therapy: the innovative frontier and challenges in prostate cancer treatment |
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| Autoren: | Jia Wei He, Pei Zhen Li, Zi Xuan Huang |
| Quelle: | Cancer Biol Ther Cancer Biology & Therapy, Vol 26, Iss 1 (2025) |
| Verlagsinformationen: | Informa UK Limited, 2025. |
| Publikationsjahr: | 2025 |
| Schlagwörter: | Prostate cancer, drug resistance, androgen receptor, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, copper metabolism, Review Article, therapeutic strategies, RC254-282 |
| Beschreibung: | Prostate cancer (PCA) remains a significant health challenge, necessitating the exploration of novel therapeutic strategies to enhance patient outcomes. Recent research has identified cuproptosis, a copper-dependent programmed cell death mechanism, as a promising target in PCA treatment. Elevated copper levels have been associated with tumor progression and therapeutic resistance, highlighting the need for innovative approaches. This review synthesizes current findings on the role of copper and cuproptosis in PCA, focusing on the mechanisms underlying cuproptosis, the identification of key biomarkers, and the therapeutic potential of copper complexes and ionophores. The integration of cuproptosis-related biomarkers into clinical practice may facilitate personalized treatment strategies, while ongoing research into copper-based therapies holds promise for overcoming limitations of traditional chemotherapy. Future directions should emphasize elucidating the molecular mechanisms of cuproptosis and optimizing therapeutic applications to improve patient outcomes in PCA. |
| Publikationsart: | Article Other literature type |
| Sprache: | English |
| ISSN: | 1555-8576 1538-4047 |
| DOI: | 10.1080/15384047.2025.2532224 |
| Zugangs-URL: | https://doaj.org/article/57b1319b80714069b4616fcfe4db58b4 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
| Dokumentencode: | edsair.doi.dedup.....891aa6f78486695a6322b7e35b3c5da6 |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Prostate cancer (PCA) remains a significant health challenge, necessitating the exploration of novel therapeutic strategies to enhance patient outcomes. Recent research has identified cuproptosis, a copper-dependent programmed cell death mechanism, as a promising target in PCA treatment. Elevated copper levels have been associated with tumor progression and therapeutic resistance, highlighting the need for innovative approaches. This review synthesizes current findings on the role of copper and cuproptosis in PCA, focusing on the mechanisms underlying cuproptosis, the identification of key biomarkers, and the therapeutic potential of copper complexes and ionophores. The integration of cuproptosis-related biomarkers into clinical practice may facilitate personalized treatment strategies, while ongoing research into copper-based therapies holds promise for overcoming limitations of traditional chemotherapy. Future directions should emphasize elucidating the molecular mechanisms of cuproptosis and optimizing therapeutic applications to improve patient outcomes in PCA. |
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| ISSN: | 15558576 15384047 |
| DOI: | 10.1080/15384047.2025.2532224 |