Do infections have a role in the pathogenesis of Alzheimer disease?
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| Title: | Do infections have a role in the pathogenesis of Alzheimer disease? |
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| Authors: | Ruth F. Itzhaki, Todd E. Golde, Michael T. Heneka, Ben Readhead |
| Source: | Nature reviews / Neurology 16(4), 193-197 (2020). doi:10.1038/s41582-020-0323-9 Itzhaki, R F, Golde, T E, Heneka, M T & Readhead, B 2020, 'Do infections have a role in the pathogenesis of Alzheimer disease?', Nature Reviews. Neurology, vol. 16, no. 4, pp. 193-197. https://doi.org/10.1038/s41582-020-0323-9 |
| Publisher Information: | Springer Science and Business Media LLC, 2020. |
| Publication Year: | 2020 |
| Subject Terms: | 0301 basic medicine, 0303 health sciences, Herpesvirus 6, Human, Apolipoprotein E4, Brain, Herpesvirus 7, Human, Herpesvirus 1, Human, Chlamydophila pneumoniae, Infections, 3. Good health, 03 medical and health sciences, Alzheimer Disease, Borrelia burgdorferi, Brain/microbiology, Humans, Infections/complications, ddc:610, Apolipoprotein E4/genetics, Alzheimer Disease/etiology, Porphyromonas gingivalis |
| Description: | The idea that infectious agents in the brain have a role in the pathogenesis of Alzheimer disease (AD) was proposed nearly 30 years ago. However, this theory failed to gain substantial traction and was largely disregarded by the AD research community for many years. Several recent discoveries have reignited interest in the infectious theory of AD, culminating in a debate on the topic at the Alzheimer's Association International Conference (AAIC) in July 2019. In this Viewpoint article, experts who participated in the AAIC debate weigh up the evidence for and against the infectious theory of AD and suggest avenues for future research and drug development. |
| Document Type: | Article |
| Language: | English |
| ISSN: | 1759-4766 1759-4758 |
| DOI: | 10.1038/s41582-020-0323-9 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/32152461 https://www.nature.com/articles/s41582-020-0323-9 https://asu.pure.elsevier.com/en/publications/do-infections-have-a-role-in-the-pathogenesis-of-alzheimer-diseas https://www.nature.com/articles/s41582-020-0323-9.epdf?no_publisher_access=1&r3_referer=nature https://www.ncbi.nlm.nih.gov/pubmed/32152461 https://www.nature.com/articles/s41582-020-0323-9.pdf https://pubmed.ncbi.nlm.nih.gov/32152461/ https://research.manchester.ac.uk/en/publications/37a12afe-fe35-4537-b0dc-d200e6785164 https://doi.org/10.1038/s41582-020-0323-9 |
| Rights: | Springer TDM |
| Accession Number: | edsair.doi.dedup.....8815c9868037d1f1ebd8dd2e8eb26c7e |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | The idea that infectious agents in the brain have a role in the pathogenesis of Alzheimer disease (AD) was proposed nearly 30 years ago. However, this theory failed to gain substantial traction and was largely disregarded by the AD research community for many years. Several recent discoveries have reignited interest in the infectious theory of AD, culminating in a debate on the topic at the Alzheimer's Association International Conference (AAIC) in July 2019. In this Viewpoint article, experts who participated in the AAIC debate weigh up the evidence for and against the infectious theory of AD and suggest avenues for future research and drug development. |
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| ISSN: | 17594766 17594758 |
| DOI: | 10.1038/s41582-020-0323-9 |