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Temporal dynamics of oxylipins and antioxidant metabolites in rainbow trout muscle are driven by diet type rather than methylmercury or selenomethionine supplementation

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Title: Temporal dynamics of oxylipins and antioxidant metabolites in rainbow trout muscle are driven by diet type rather than methylmercury or selenomethionine supplementation
Authors: Bidon, Marius, Heraud, Cécile, Marchán-Moreno, Claudia, Larroquet, Laurence, Reversat, Guillaume, Vigor, Claire, Oger, Camille, Galano, Jean-Marie, Durand, Thierry, Pedrero, Zoyne, Fontagné-Dicharry, Stéphanie, Roy, Jérôme
Contributors: Iprem, Hal
Source: Free Radical Biology and Medicine. 239:417-431
Publisher Information: Elsevier BV, 2025.
Publication Year: 2025
Subject Terms: [CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.POLY] Chemical Sciences/Polymers, [CHIM.THEO] Chemical Sciences/Theoretical and/or physical chemistry, [CHIM.ANAL] Chemical Sciences/Analytical chemistry
Description: Tuna by-products in aquafeed pose challenges due to heavy metals like mercury (Hg), which has pro-oxidant effects. However, they also contain selenium (Se), an antioxidant oligoelement. This study assessed the oxidative impact of these elements in juvenile rainbow trout over a 6-month feeding trial. Fish were fed plant-based or tuna-based diets, with or without supplementation of methylmercury (MeHg) and selenomethionine (SeMet). Muscle samples were collected at 0, 21, 84, and 168 days to analyze fatty acid profiles, non-enzymatic oxylipins, and antioxidant metabolites (glutathione, vitamin E). Tuna-fed fish exhibited higher oxylipin levels and lower antioxidant metabolites compared to plant-fed fish. Notably, oxylipin levels remained elevated at 84 and 168 days in tuna-fed fish, correlating with a decrease in the GSH:GSSG ratio. In contrast, plant-fed fish showed a transient increase in oxylipins at 84 days, which normalized by day 168, aligning with a temporary drop in the GSH:GSSG ratio. MeHg and SeMet supplementation did not alter these trends. Surprisingly, these findings, along with a previous study, suggest that prolonged oxidative stress in tuna-fed fish is more closely linked to Se bioaccumulation than Hg. Future work should investigate dietary Se concentration and form to better understand these results.
Document Type: Article
File Description: application/pdf
Language: English
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2025.07.043
Access URL: https://univ-pau.hal.science/hal-05225823v1/document
https://doi.org/10.1016/j.freeradbiomed.2025.07.043
https://univ-pau.hal.science/hal-05225823v1
Rights: CC BY
Accession Number: edsair.doi.dedup.....86cbd04fe6cf6cd681b8ab2a19f0498f
Database: OpenAIRE
Description
Abstract:Tuna by-products in aquafeed pose challenges due to heavy metals like mercury (Hg), which has pro-oxidant effects. However, they also contain selenium (Se), an antioxidant oligoelement. This study assessed the oxidative impact of these elements in juvenile rainbow trout over a 6-month feeding trial. Fish were fed plant-based or tuna-based diets, with or without supplementation of methylmercury (MeHg) and selenomethionine (SeMet). Muscle samples were collected at 0, 21, 84, and 168 days to analyze fatty acid profiles, non-enzymatic oxylipins, and antioxidant metabolites (glutathione, vitamin E). Tuna-fed fish exhibited higher oxylipin levels and lower antioxidant metabolites compared to plant-fed fish. Notably, oxylipin levels remained elevated at 84 and 168 days in tuna-fed fish, correlating with a decrease in the GSH:GSSG ratio. In contrast, plant-fed fish showed a transient increase in oxylipins at 84 days, which normalized by day 168, aligning with a temporary drop in the GSH:GSSG ratio. MeHg and SeMet supplementation did not alter these trends. Surprisingly, these findings, along with a previous study, suggest that prolonged oxidative stress in tuna-fed fish is more closely linked to Se bioaccumulation than Hg. Future work should investigate dietary Se concentration and form to better understand these results.
ISSN:08915849
DOI:10.1016/j.freeradbiomed.2025.07.043