Shh and ROCK1 modulate the dynamic epithelial morphogenesis in circumvallate papilla development
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| Názov: | Shh and ROCK1 modulate the dynamic epithelial morphogenesis in circumvallate papilla development |
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| Autori: | Lee, JM, Kim, JY, Jung, HS, Cho, SW, Cho, JY, Jung, HI, Kim, YJ, Cho, KW, Lee, MJ |
| Prispievatelia: | Jae-Young Kim, Min-Jung Lee, Kyoung-Won Cho, Jong-Min Lee, Yeun-Jung Kim, Ji-Youn Kim, Hye-In Jung, Je-Yoel Cho, Sung-Won Cho, Han-Sung Jung, Kim, Yeun Jung, Kim, Ji Youn, Lee, Min Jung, Lee, Jong Min, Jung, Han Sung, Cho, Kyoung Won, Cho, Sung Won |
| Zdroj: | Developmental Biology. 325:273-280 |
| Informácie o vydavateľovi: | Elsevier BV, 2009. |
| Rok vydania: | 2009 |
| Predmety: | 0301 basic medicine, Morphogenesis - Drug Effects, Pyridines, Proliferation, Cell Movement/drug effects, Developmental/drug effects, Epithelium/drug effects, Shh, Epithelium, Mice, Models, Cell Movement, rho-Associated Kinases/metabolism, Morphogenesis, Cytoskeleton, Pyridines/pharmacology, Mice, Inbred Icr, Mice, Inbred ICR, rho-Associated Kinases, 0303 health sciences, Tongue/enzymology, Gene Expression Regulation, Developmental, Rho-Associated Kinases - Antagonists & Inhibitors - Metabolism, rho-Associated Kinases/antagonists & inhibitors, Inbred Icr, Inbred ICR, Hedgehog Proteins - Metabolism, Cell Movement - Drug Effects, Wnt11, Models, Biological, 03 medical and health sciences, Organ Culture Techniques, Tongue, ROCK1, Morphogenesis*/drug effects, Tongue - Cytology - Embryology - Enzymology, Hedgehog Proteins/metabolism, Animals, Epithelium/embryology, Hedgehog Proteins, Gene Expression Regulation, Developmental - Drug Effects, Molecular Biology, Tongue/embryology, Amides/pharmacology, Tongue/cytology, Cell Biology, Biological, Pyridines - Pharmacology, Circumvallate papilla, Amides, Epithelium/enzymology, Epithelium/metabolism, Gene Expression Regulation, Epithelium - Drug Effects - Embryology - Enzymology - Metabolism, Developmental - Drug Effects, Amides - Pharmacology, Developmental Biology |
| Popis: | In rodents, a circumvallate papilla (CVP) develops with dynamic changes in epithelial morphogenesis during early tongue development. Molecular and cellular studies of CVP development revealed that there would be two different mechanisms in the apex and the trench wall forming regions with specific expression patterns of Wnt11 and Shh. Molecular interactions were examined using in vitro organ culture with over-expression of Shh, important signalling molecules and various inhibitors revealed that there are two significant different mechanisms in CVP formation by Wnt11 and Shh expressions. Wnt, a well known key molecule to initiate taste papillae, would govern Rho activation and cytoskeleton formation in the apex epithelium of CVP. In contrast, Shh regulates the cell proliferation to differentiate taste buds and to invaginate the epithelium for development of von Ebner's gland (VEG). Based on these results, we suggest that these different molecular signalling cascades of Wnt11 and Shh would play crucial roles in specific morphogenesis and pattern formation of CVP during early mouse embryo development. |
| Druh dokumentu: | Article |
| Popis súboru: | 273~280 |
| Jazyk: | English |
| ISSN: | 0012-1606 |
| DOI: | 10.1016/j.ydbio.2008.10.034 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/19014928 https://yonsei.pure.elsevier.com/en/publications/shh-and-rock1-modulate-the-dynamic-epithelial-morphogenesis-in-ci https://www.sciencedirect.com/science/article/abs/pii/S0012160608013006 https://core.ac.uk/display/37994743 https://www.sciencedirect.com/science/article/pii/S0012160608013006 https://ir.ymlib.yonsei.ac.kr/handle/22282913/103451 https://www.ncbi.nlm.nih.gov/pubmed/19014928 http://hdl.handle.net/10722/169554 |
| Rights: | Elsevier Non-Commercial CC BY NC ND |
| Prístupové číslo: | edsair.doi.dedup.....86c6e6d6d3facfca1ecbe77167e604f6 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | In rodents, a circumvallate papilla (CVP) develops with dynamic changes in epithelial morphogenesis during early tongue development. Molecular and cellular studies of CVP development revealed that there would be two different mechanisms in the apex and the trench wall forming regions with specific expression patterns of Wnt11 and Shh. Molecular interactions were examined using in vitro organ culture with over-expression of Shh, important signalling molecules and various inhibitors revealed that there are two significant different mechanisms in CVP formation by Wnt11 and Shh expressions. Wnt, a well known key molecule to initiate taste papillae, would govern Rho activation and cytoskeleton formation in the apex epithelium of CVP. In contrast, Shh regulates the cell proliferation to differentiate taste buds and to invaginate the epithelium for development of von Ebner's gland (VEG). Based on these results, we suggest that these different molecular signalling cascades of Wnt11 and Shh would play crucial roles in specific morphogenesis and pattern formation of CVP during early mouse embryo development. |
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| ISSN: | 00121606 |
| DOI: | 10.1016/j.ydbio.2008.10.034 |