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Atmospheric levels and cytotoxicity of polycyclic aromatic hydrocarbons and oxygenated-PAHs in PM2.5 in the Beijing-Tianjin-Hebei region

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Název: Atmospheric levels and cytotoxicity of polycyclic aromatic hydrocarbons and oxygenated-PAHs in PM2.5 in the Beijing-Tianjin-Hebei region
Autoři: Xinyi Niu, Kin Fai Ho, Qiyuan Wang, Junji Cao, Jian Sun, Zhuzi Zhao, Yu Huang, Yaqing Zhou, Steven Sai Hang Ho
Zdroj: Environmental Pollution. 231:1075-1084
Informace o vydavateli: Elsevier BV, 2017.
Rok vydání: 2017
Témata: China, Cytotoxicity, SEASONAL-VARIATION, AMBIENT AIR, Environmental Sciences & Ecology, Naphthalenes, CHEMICAL-COMPOSITION, 01 natural sciences, Chrysenes, DIESEL EXHAUST PARTICLES, Pahs, Pm2.5, PARTICULATE MATTER, Air Pollution, 11. Sustainability, Opahs, OXIDATIVE STRESS, Polycyclic Aromatic Hydrocarbons, 0105 earth and related environmental sciences, Air Pollutants, Aldehydes, Science & Technology, NITRIC-OXIDE, Atmosphere, AIR-POLLUTION, NITRATED PAHS, 6. Clean water, 3. Good health, Oxygen, 13. Climate action, Beijing, Particulate Matter, Seasons, Life Sciences & Biomedicine, CANCER-RISK ASSESSMENT, Environmental Sciences
Popis: The chemical composition of PM2.5 and cellular effects from exposure to fine aerosol extracts were studied for samples collected in Beijing, Tianjin, Shijiazhuang, and Hengshui, China in winter 2015. Effects of priority polycyclic aromatic hydrocarbons (PAHs) and their oxygenated derivatives (OPAHs) in PM2.5 on cell cultures were a major focus of the study. Total quantified PAHs and OPAHs at Shijiazhuang and Hengshui were higher than at Beijing and Tianjin, and benz(a)anthracene, chrysene and 1,8-naphthalic anhydride were the most abundant species. Exposure to PM2.5 extracts caused a concentration-dependent decline in cell viability and a dose-dependent increase in nitric oxide production. Two cytokines, tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), also increased when A549 test cells were exposed to PM2.5 extracts. PAHs and OPAHs in PM2.5 can potentially cause cell damage and induce cytotoxicity and pro-inflammatory responses: benzo(a)anthracene-7,12-dione was highly correlated with NO production, dibenz(a,h)anthracene and 1,4-chrysenequinone were correlated with TNF-α production, and 1-naphthaldehyde was significantly correlated with IL-6 production. The study provides a new approach for evaluating relationships between air-quality and cell toxicity with respect to specific chemicals.
Druh dokumentu: Article
Jazyk: English
ISSN: 0269-7491
DOI: 10.1016/j.envpol.2017.08.099
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/28922714
https://europepmc.org/article/MED/28922714
https://www.sciencedirect.com/science/article/pii/S0269749117310126
https://pubmed.ncbi.nlm.nih.gov/28922714/
https://www.ncbi.nlm.nih.gov/pubmed/28922714
Rights: Elsevier TDM
Přístupové číslo: edsair.doi.dedup.....8664430c3083ecdf0cacdf36cdf0a9f8
Databáze: OpenAIRE
Popis
Abstrakt:The chemical composition of PM2.5 and cellular effects from exposure to fine aerosol extracts were studied for samples collected in Beijing, Tianjin, Shijiazhuang, and Hengshui, China in winter 2015. Effects of priority polycyclic aromatic hydrocarbons (PAHs) and their oxygenated derivatives (OPAHs) in PM2.5 on cell cultures were a major focus of the study. Total quantified PAHs and OPAHs at Shijiazhuang and Hengshui were higher than at Beijing and Tianjin, and benz(a)anthracene, chrysene and 1,8-naphthalic anhydride were the most abundant species. Exposure to PM2.5 extracts caused a concentration-dependent decline in cell viability and a dose-dependent increase in nitric oxide production. Two cytokines, tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), also increased when A549 test cells were exposed to PM2.5 extracts. PAHs and OPAHs in PM2.5 can potentially cause cell damage and induce cytotoxicity and pro-inflammatory responses: benzo(a)anthracene-7,12-dione was highly correlated with NO production, dibenz(a,h)anthracene and 1,4-chrysenequinone were correlated with TNF-α production, and 1-naphthaldehyde was significantly correlated with IL-6 production. The study provides a new approach for evaluating relationships between air-quality and cell toxicity with respect to specific chemicals.
ISSN:02697491
DOI:10.1016/j.envpol.2017.08.099