N4-acetylcytidine (ac4C) promotes mRNA localization to stress granules
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| Názov: | N4-acetylcytidine (ac4C) promotes mRNA localization to stress granules |
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| Autori: | Pavel Kudrin, Ankita Singh, David Meierhofer, Anna Kuśnierczyk, Ulf Andersson Vang Ørom |
| Zdroj: | EMBO Rep EMBO Reports Kudrin, P, Singh, A, Meierhofer, D, Kuśnierczyk, A & Ørom, U A V 2024, 'N4-acetylcytidine (ac4C) promotes mRNA localization to stress granules', EMBO Reports, vol. 25, no. 4, pp. 1814-1834. https://doi.org/10.1038/s44319-024-00098-6 |
| Informácie o vydavateľovi: | Springer Science and Business Media LLC, 2023. |
| Rok vydania: | 2023 |
| Predmety: | RNA, Messenger/genetics, 0301 basic medicine, Translation, 0303 health sciences, RNA Acetylation, Cytidine/genetics, RNA-Binding Proteins, Cytidine, Article, Stress Granules, 03 medical and health sciences, mRNA Localization, RNA, Messenger, RNA-Binding Proteins/metabolism |
| Popis: | Stress granules are an integral part of the stress response that are formed from non-translating mRNAs aggregated with proteins. While much is known about stress granules, the factors that drive their mRNA localization are incompletely described. Modification of mRNA can alter the properties of the nucleobases and affect processes such as translation, splicing and localization of individual transcripts. Here, we show that the RNA modification N4-acetylcytidine (ac4C) on mRNA associates with transcripts enriched in stress granules and that stress granule localized transcripts with ac4C are specifically translationally regulated. We also show that ac4C on mRNA can mediate localization of the protein NOP58 to stress granules. Our results suggest that acetylation of mRNA regulates localization of both stress-sensitive transcripts and RNA-binding proteins to stress granules and adds to our understanding of the molecular mechanisms responsible for stress granule formation. |
| Druh dokumentu: | Article Other literature type |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1469-3178 |
| DOI: | 10.1038/s44319-024-00098-6 |
| DOI: | 10.1101/2023.05.22.541693 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/38413733 http://hdl.handle.net/21.11116/0000-000E-82D0-3 http://hdl.handle.net/21.11116/0000-000E-82CE-7 https://hdl.handle.net/11250/3196009 http://www.scopus.com/inward/record.url?scp=85185962795&partnerID=8YFLogxK https://pure.au.dk/portal/en/publications/c05252ca-59c6-44b2-98f4-0953c42f80af https://doi.org/10.1038/s44319-024-00098-6 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible. |
| Prístupové číslo: | edsair.doi.dedup.....85dfe496760da701509de6e95f8132b5 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Stress granules are an integral part of the stress response that are formed from non-translating mRNAs aggregated with proteins. While much is known about stress granules, the factors that drive their mRNA localization are incompletely described. Modification of mRNA can alter the properties of the nucleobases and affect processes such as translation, splicing and localization of individual transcripts. Here, we show that the RNA modification N4-acetylcytidine (ac4C) on mRNA associates with transcripts enriched in stress granules and that stress granule localized transcripts with ac4C are specifically translationally regulated. We also show that ac4C on mRNA can mediate localization of the protein NOP58 to stress granules. Our results suggest that acetylation of mRNA regulates localization of both stress-sensitive transcripts and RNA-binding proteins to stress granules and adds to our understanding of the molecular mechanisms responsible for stress granule formation. |
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| ISSN: | 14693178 |
| DOI: | 10.1038/s44319-024-00098-6 |