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Chromatin landscape associated with sexual differentiation in a UV sex determination system

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Titel: Chromatin landscape associated with sexual differentiation in a UV sex determination system
Autoren: Gueno, Josselin, Borg, Michael, Bourdareau, Simon, Cossard, Guillaume, Godfroy, Olivier, Lipinska, Agnieszka, Tirichine, Leila, Cock, J. Mark, Coelho, Susana
Weitere Verfasser: Cock, J. Mark, Laboratoire de Biologie Intégrative des Modèles Marins (LBI2M), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff = Roscoff Marine Station (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Austrian Academy of Sciences (OeAW), Station biologique de Roscoff = Roscoff Marine Station (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Department of Ecology and Evolution UNIL, Lausanne = Département d'écologie et évolution (DEE), Université de Lausanne = University of Lausanne (UNIL), Unité en Sciences Biologiques et Biotechnologies de Nantes (US2B), Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), ERC : 864038, CNRS, Sorbonne Université, ANR-19-CE20-0028,Epicycle,Régulation génétique et épigénétique du cycle de vie de l'algue brune Ectocarpus(2019), European Project: 638240,H2020,ERC-2014-STG,SEXSEA(2015)
Quelle: Nucleic Acids Res
Nucleic Acids Research
Verlagsinformationen: Oxford University Press (OUP), 2022.
Publikationsjahr: 2022
Schlagwörter: 0301 basic medicine, Sex Chromosomes, Phaeophyceae, [SDV]Life Sciences [q-bio], Gene regulation, Chromatin and Epigenetics, Molecular, MESH: Sex Chromosomes, MESH: Phaeophyta, MESH: Haploidy, Haploidy, Chromatin, [SDV] Life Sciences [q-bio], Evolution, Molecular, 03 medical and health sciences, MESH: Dosage Compensation, Genetic, Dosage Compensation, Genetic, MESH: Evolution
Beschreibung: In many eukaryotes, such as dioicous mosses and many algae, sex is determined by UV sex chromosomes and is expressed during the haploid phase of the life cycle. In these species, the male and female developmental programs are initiated by the presence of the U- or V-specific regions of the sex chromosomes but, as in XY and ZW systems, sexual differentiation is largely driven by autosomal sex-biased gene expression. The mechanisms underlying the regulation of sex-biased expression of genes during sexual differentiation remain elusive. Here, we investigated the extent and nature of epigenomic changes associated with UV sexual differentiation in the brown alga Ectocarpus, a model UV system. Six histone modifications were quantified in near-isogenic lines, leading to the identification of 16 chromatin signatures across the genome. Chromatin signatures correlated with levels of gene expression and histone PTMs changes in males versus females occurred preferentially at genes involved in sex-specific pathways. Despite the absence of chromosome scale dosage compensation and the fact that UV sex chromosomes recombine across most of their length, the chromatin landscape of these chromosomes was remarkably different to that of autosomes. Hotspots of evolutionary young genes in the pseudoautosomal regions appear to drive the exceptional chromatin features of UV sex chromosomes.
Publikationsart: Article
Other literature type
Dateibeschreibung: application/pdf
Sprache: English
ISSN: 1362-4962
0305-1048
DOI: 10.1093/nar/gkac145
Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/35253891
https://cnrs.hal.science/hal-03608518v1/document
https://cnrs.hal.science/hal-03608518v1
https://doi.org/10.1093/nar/gkac145
Rights: CC BY
CC BY NC
URL: http://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Dokumentencode: edsair.doi.dedup.....85d273cb6b3c949d9b9e32c4061cbe32
Datenbank: OpenAIRE
Beschreibung
Abstract:In many eukaryotes, such as dioicous mosses and many algae, sex is determined by UV sex chromosomes and is expressed during the haploid phase of the life cycle. In these species, the male and female developmental programs are initiated by the presence of the U- or V-specific regions of the sex chromosomes but, as in XY and ZW systems, sexual differentiation is largely driven by autosomal sex-biased gene expression. The mechanisms underlying the regulation of sex-biased expression of genes during sexual differentiation remain elusive. Here, we investigated the extent and nature of epigenomic changes associated with UV sexual differentiation in the brown alga Ectocarpus, a model UV system. Six histone modifications were quantified in near-isogenic lines, leading to the identification of 16 chromatin signatures across the genome. Chromatin signatures correlated with levels of gene expression and histone PTMs changes in males versus females occurred preferentially at genes involved in sex-specific pathways. Despite the absence of chromosome scale dosage compensation and the fact that UV sex chromosomes recombine across most of their length, the chromatin landscape of these chromosomes was remarkably different to that of autosomes. Hotspots of evolutionary young genes in the pseudoautosomal regions appear to drive the exceptional chromatin features of UV sex chromosomes.
ISSN:13624962
03051048
DOI:10.1093/nar/gkac145