Effects of sodium fluoride, vitamin D, and calcium on cortical bone remodeling in osteoporotic patients
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| Názov: | Effects of sodium fluoride, vitamin D, and calcium on cortical bone remodeling in osteoporotic patients |
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| Autori: | Kragstrup, J, Shijie, Z, Mosekilde, L, Melsen, F |
| Zdroj: | Calcified Tissue International. 45:337-341 |
| Informácie o vydavateľovi: | Springer Science and Business Media LLC, 1989. |
| Rok vydania: | 1989 |
| Predmety: | 0301 basic medicine, 0303 health sciences, Bone Regeneration, Bone Resorption/pathology, Bone and Bones/drug effects, Vitamin D/pharmacology, Middle Aged, Bone Regeneration/drug effects, Sodium Fluoride/pharmacology, Calcium/pharmacology, Bone and Bones, 03 medical and health sciences, Humans, Osteoporosis, Sodium Fluoride, Calcium, Female, Bone Resorption, Vitamin D, Osteoporosis/pathology, Aged |
| Popis: | The purpose of this histomorphometric study of iliac bone biopsies from 10 postmenopausal osteoporotic patients was to describe the effects of sodium fluoride (combined with calcium and vitamin D) on remodeling in cortical bone after 6 months and after 5 years of treatment. Biopsies had been fixed in absolute methanol, embedded undecalcified in methylmetacrylate, and cut on a heavyduty microtome. The therapy had no effect on the thickness of cortical bone in the iliac crest but increased the porosity slightly. It had no statistically significant effect on depth of resorption or thickness of new walls formed at remodeling sites but treatment increased the fraction of osteons undergoing remodeling in cortical bone. After 6 months of treatment, the increase was due to an enhanced activation of new remodeling sites, but in biopsies taken after 5 years of treatment, some degree of mineralization defect was observed and the duration of the remodeling cycle appeared to be prolonged. The mechanism underlying this qualitative change in the response to treatment is unknown, and it is unclear whether the mineralization defect may be prevented by, e.g., an altered supplementation of vitamin D or calcium. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1432-0827 0171-967X |
| DOI: | 10.1007/bf02556003 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/2509023 https://www.ncbi.nlm.nih.gov/pubmed/2509023 https://link.springer.com/article/10.1007/BF02556003 |
| Rights: | Springer TDM |
| Prístupové číslo: | edsair.doi.dedup.....8549ab26d731b97a18aa9b80bb0ef5d6 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | The purpose of this histomorphometric study of iliac bone biopsies from 10 postmenopausal osteoporotic patients was to describe the effects of sodium fluoride (combined with calcium and vitamin D) on remodeling in cortical bone after 6 months and after 5 years of treatment. Biopsies had been fixed in absolute methanol, embedded undecalcified in methylmetacrylate, and cut on a heavyduty microtome. The therapy had no effect on the thickness of cortical bone in the iliac crest but increased the porosity slightly. It had no statistically significant effect on depth of resorption or thickness of new walls formed at remodeling sites but treatment increased the fraction of osteons undergoing remodeling in cortical bone. After 6 months of treatment, the increase was due to an enhanced activation of new remodeling sites, but in biopsies taken after 5 years of treatment, some degree of mineralization defect was observed and the duration of the remodeling cycle appeared to be prolonged. The mechanism underlying this qualitative change in the response to treatment is unknown, and it is unclear whether the mineralization defect may be prevented by, e.g., an altered supplementation of vitamin D or calcium. |
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| ISSN: | 14320827 0171967X |
| DOI: | 10.1007/bf02556003 |