Long term exposure to low level air pollution and mortality in eight European cohorts within the ELAPSE project: pooled analysis: pooled analysis
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| Název: | Long term exposure to low level air pollution and mortality in eight European cohorts within the ELAPSE project: pooled analysis: pooled analysis |
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| Autoři: | Debora Rizzuto, Sara Schramm, Matthias Ketzel, Yvonne T. van der Schouw, Maciej Strak, Nicole A.H. Janssen, Amar Mehta, Shuo Liu, Kathrin Wolf, Gabriele Nagel, Francesco Forastiere, Jørgen Brandt, Tom Bellander, W M Monique Verschuren, Mariska Bauwelinck, Barbara Hoffmann, Terese Bekkevold, Annette Peters, Jeanette Therming Jørgensen, Matteo Renzi, Gudrun Weinmayr, Patrik K. E. Magnusson, Massimo Stafoggia, Anton Lager, Ole Raaschou-Nielsen, Karl-Heinz Jöckel, Danielle Vienneau, Jie Chen, Kees de Hoogh, Hans Concin, Torben Sigsgaard, Göran Pershagen, Anne Tjønneland, Gianluca Severi, Petter Ljungman, Daniela Fecht, Jochem O. Klompmaker, Sophia Rodopoulou, Mette Sørensen, Richard Atkinson, Marie-Christine Boutron-Ruault, Bert Brunekreef, Zorana Jovanovic Andersen, Evangelia Samoli, Giulia Cesaroni, Gerard Hoek, John S. Gulliver, Klea Katsouyanni, Ulla Arthur Hvidtfeldt, Ole Hertel, Karin Leander, Bente Oftedal |
| Přispěvatelé: | HAL UVSQ, Équipe, Faculty of Economic and Social Sciences and Solvay Business School, Sociology, Open Repository DS7.6 Demo, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut Gustave Roussy (IGR), U.S. Environmental Protection Agency, EPA: R-82811201, Health Effects Institute, HEI: 4954-RFA14-3/16-5-3, Funding: This work was supported by Health Effects Institute (HEI) research agreement (grant No 4954-RFA14-3/16-5-3). Research described in this article was conducted under contract to the HEI, an organisation jointly funded by the US Environmental Protection Agency (EPA) (assistance award No R-82811201) and certain motor vehicle and engine manufacturers. The contents of this article do not necessarily reflect the views of HEI, or its sponsors, nor do they necessarily reflect the views and policies of the EPA or motor vehicle and engine manufacturers. Competing interests: All authors have completed the ICMJE uniform disclosure form at http://www.icmje.org/coi_disclosure.pdf and declare: support from the Health Effects Institute for the submitted work, no financial relationships with any organisations that might have an interest in the submitted work in the previous three years, no other relationships or activities that could appear to have influenced the submitted work. Ethical approval: All included cohort studies were approved by the medical ethics committees in their respective countries. Data sharing: No additional data available. The corresponding author affirms that the manuscript is an honest, accurate, and transparent account of the study being reported, that no important aspects of the study have been omitted, and that any discrepancies from the study as planned (and, if relevant, registered) have been explained. |
| Zdroj: | BMJ Strak, M, Weinmayr, G, Rodopoulou, S, Chen, J, de Hoogh, K, Andersen, Z J, Atkinson, R, Bauwelinck, M, Bekkevold, T, Bellander, T, Boutron-Ruault, M-C, Brandt, J, Cesaroni, G, Concin, H, Fecht, D, Forastiere, F, Gulliver, J, Hertel, O, Hoffmann, B, Hvidtfeldt, U A, Janssen, N A H, Jöckel, K-H, Jørgensen, J T, Ketzel, M, Klompmaker, J O, Lager, A, Leander, K, Liu, S, Ljungman, P, Magnusson, P K E, Mehta, A J, Nagel, G, Oftedal, B, Pershagen, G, Peters, A, Raaschou-Nielsen, O, Renzi, M, Rizzuto, D, van der Schouw, Y T, Schramm, S, Severi, G, Sigsgaard, T, Sørensen, M, Stafoggia, M, Tjønneland, A, Verschuren, W M M, Vienneau, D, Wolf, K, Katsouyanni, K, Brunekreef, B, Hoek, G & Samoli, E 2021, 'Long term exposure to low level air pollution and mortality in eight European cohorts within the ELAPSE project : pooled analysis', BMJ, vol. 374, n1904. https://doi.org/10.1136/bmj.n1904 Strak, M, Weinmayr, G, Rodopoulou, S, Chen, J, de Hoogh, K, Andersen, Z J, Atkinson, R, Bauwelinck, M, Bekkevold, T, Bellander, T, Boutron-Ruault, M-C, Brandt, J, Cesaroni, G, Concin, H, Fecht, D, Forastiere, F, Gulliver, J, Hertel, O, Hoffmann, B, Hvidtfeldt, U A, Janssen, N A H, Jockel, K-H, Jorgensen, J, Ketzel, M, Klompmaker, J, Lager, A, Leander, K, Liu, S, Ljungman, P, Magnusson, P K E, Mehta, A J, Nagel, G, Oftedal, B, Pershagen, G, Peters, A, Raaschou-Nielsen, O, Renzi, M, Rizzuto, D, Schouw, Y T V D, Schramm, S, Severi, G, Sigsgaard, T, Sørensen, M, Stafoggia, M, Tjonneland, A, Verschuren, W M M, Vienneau, D, Wolf, K, Katsouyanni, K, Brunekreef, B, Hoek, G & Samoli, E 2021, ' Long term exposure to low level air pollution and mortality in eight European cohorts within the ELAPSE project : pooled analysis ', B M J, vol. 374, 1904 . https://doi.org/10.1136/bmj.n1904 BMJ 374:n1904 (2021) The BMJ Strak, M, Weinmayr, G, Rodopoulou, S, Chen, J, de Hoogh, K, Andersen, Z J, Atkinson, R, Bauwelinck, M, Bekkevold, T, Bellander, T, Boutron-Ruault, M-C, Brandt, J, Cesaroni, G, Concin, H, Fecht, D, Forastiere, F, Gulliver, J, Hertel, O, Hoffmann, B, Hvidtfeldt, U A, Janssen, N A H, Jöckel, K-H, Jørgensen, J T, Ketzel, M, Klompmaker, J O, Lager, A, Leander, K, Liu, S, Ljungman, P, Magnusson, P K E, Mehta, A J, Nagel, G, Oftedal, B, Pershagen, G, Peters, A, Raaschou-Nielsen, O, Renzi, M, Rizzuto, D, van der Schouw, Y T, Schramm, S, Severi, G, Sigsgaard, T, Sørensen, M, Stafoggia, M, Tjønneland, A, Verschuren, W M M, Vienneau, D, Wolf, K, Katsouyanni, K, Brunekreef, B, Hoek, G & Samoli, E 2021, 'Long term exposure to low level air pollution and mortality in eight European cohorts within the ELAPSE project : pooled analysis', BMJ (Clinical research ed.), vol. 374, n1904. https://doi.org/10.1136/bmj.n1904 |
| Informace o vydavateli: | BMJ, 2021. |
| Rok vydání: | 2021 |
| Témata: | Mortality, air pollution, [SDV]Life Sciences [q-bio], MODELS, Medizin, PM2.5, General & Internal, NO2, 01 natural sciences, 1117 Public Health and Health Services, 03 medical and health sciences, Medicine, General & Internal, 0302 clinical medicine, General & Internal Medicine, Air Pollution, 11. Sustainability, Air Pollutants/adverse effects, Humans, Noncommunicable Diseases/mortality, Noncommunicable Diseases, Cardiovascular Diseases/mortality, ASSOCIATIONS, 0105 earth and related environmental sciences, RISK, Air Pollutants, Science & Technology, STABILITY, Research, O-3, 1103 Clinical Sciences, Environmental Exposure, Air Pollution/adverse effects, GLOBAL BURDEN, 16. Peace & justice, 3. Good health, [SDV] Life Sciences [q-bio], Europe, Cardiovascular Diseases, 13. Climate action, Medicine, FINE PARTICULATE MATTER, CANADIAN CENSUS HEALTH, Life Sciences & Biomedicine, Environmental Exposure/adverse effects |
| Popis: | Objective To investigate the associations between air pollution and mortality, focusing on associations below current European Union, United States, and World Health Organization standards and guidelines. Design Pooled analysis of eight cohorts. Setting Multicentre project Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE) in six European countries. Participants 325 367 adults from the general population recruited mostly in the 1990s or 2000s with detailed lifestyle data. Stratified Cox proportional hazard models were used to analyse the associations between air pollution and mortality. Western Europe-wide land use regression models were used to characterise residential air pollution concentrations of ambient fine particulate matter (PM 2.5 ), nitrogen dioxide, ozone, and black carbon. Main outcome measures Deaths due to natural causes and cause specific mortality. Results Of 325 367 adults followed-up for an average of 19.5 years, 47 131 deaths were observed. Higher exposure to PM 2.5 , nitrogen dioxide, and black carbon was associated with significantly increased risk of almost all outcomes. An increase of 5 µg/m 3 in PM 2.5 was associated with 13% (95% confidence interval 10.6% to 15.5%) increase in natural deaths; the corresponding figure for a 10 µg/m 3 increase in nitrogen dioxide was 8.6% (7% to 10.2%). Associations with PM 2.5 , nitrogen dioxide, and black carbon remained significant at low concentrations. For participants with exposures below the US standard of 12 µg/m 3 an increase of 5 µg/m 3 in PM 2.5 was associated with 29.6% (14% to 47.4%) increase in natural deaths. Conclusions Our study contributes to the evidence that outdoor air pollution is associated with mortality even at low pollution levels below the current European and North American standards and WHO guideline values. These findings are therefore an important contribution to the debate about revision of air quality limits, guidelines, and standards, and future assessments by the Global Burden of Disease. |
| Druh dokumentu: | Article Other literature type |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1756-1833 |
| DOI: | 10.1136/bmj.n1904 |
| DOI: | 10.5451/unibas-ep89545 |
| Přístupová URL adresa: | https://www.bmj.com/content/bmj/374/bmj.n1904.full.pdf https://pubmed.ncbi.nlm.nih.gov/34470785 https://hal.science/hal-03401763v1 https://hal.science/hal-03401763v1/document https://doi.org/10.1136/bmj.n1904 https://openaccess.sgul.ac.uk/id/eprint/113619/1/bmj.n1904.full.pdf https://www.bmj.com/content/374/bmj.n1904 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8409282 https://forskning.ruc.dk/en/publications/long-term-exposure-to-low-level-air-pollution-and-mortality-in-ei https://rivm.openrepository.com/handle/10029/625231 https://www.bmj.com/content/bmj/374/bmj.n1904.full.pdf https://findanexpert.unimelb.edu.au/scholarlywork/1594583-long-term-exposure-to-low-level-air-pollution-and-mortality-in-eight-european-cohorts-within-the-elapse-project--pooled-analysis. http://hdl.handle.net/10044/1/91573 https://pure.au.dk/portal/en/publications/dd84d1dd-0226-4953-92ed-9f24245f324e https://edoc.unibas.ch/89545/ https://curis.ku.dk/ws/files/279382072/Long_term_exposure_to_low_level_air_pollution.pdf https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=62967 https://biblio.vub.ac.be/vubir/(220d77b0-8539-4b88-a3e0-9d1eb1e7c226).html https://hdl.handle.net/11250/2984913 https://hdl.handle.net/10029/625231 https://pure.au.dk/portal/en/publications/dd84d1dd-0226-4953-92ed-9f24245f324e https://doi.org/10.1136/bmj.n1904 https://pure.au.dk/ws/files/274827771/bmj.n1904.full.pdf https://www.ncbi.nlm.nih.gov/pubmed/34470785 https://doi.org/10.1136/bmj.n1904 https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85114298591 |
| Rights: | CC BY NC URL: http://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (http://creativecommons.org/licenses/by-nc/4.0/) . |
| Přístupové číslo: | edsair.doi.dedup.....83e10af707627283f52809b0ed38d5e3 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Objective To investigate the associations between air pollution and mortality, focusing on associations below current European Union, United States, and World Health Organization standards and guidelines. Design Pooled analysis of eight cohorts. Setting Multicentre project Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE) in six European countries. Participants 325 367 adults from the general population recruited mostly in the 1990s or 2000s with detailed lifestyle data. Stratified Cox proportional hazard models were used to analyse the associations between air pollution and mortality. Western Europe-wide land use regression models were used to characterise residential air pollution concentrations of ambient fine particulate matter (PM 2.5 ), nitrogen dioxide, ozone, and black carbon. Main outcome measures Deaths due to natural causes and cause specific mortality. Results Of 325 367 adults followed-up for an average of 19.5 years, 47 131 deaths were observed. Higher exposure to PM 2.5 , nitrogen dioxide, and black carbon was associated with significantly increased risk of almost all outcomes. An increase of 5 µg/m 3 in PM 2.5 was associated with 13% (95% confidence interval 10.6% to 15.5%) increase in natural deaths; the corresponding figure for a 10 µg/m 3 increase in nitrogen dioxide was 8.6% (7% to 10.2%). Associations with PM 2.5 , nitrogen dioxide, and black carbon remained significant at low concentrations. For participants with exposures below the US standard of 12 µg/m 3 an increase of 5 µg/m 3 in PM 2.5 was associated with 29.6% (14% to 47.4%) increase in natural deaths. Conclusions Our study contributes to the evidence that outdoor air pollution is associated with mortality even at low pollution levels below the current European and North American standards and WHO guideline values. These findings are therefore an important contribution to the debate about revision of air quality limits, guidelines, and standards, and future assessments by the Global Burden of Disease. |
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| ISSN: | 17561833 |
| DOI: | 10.1136/bmj.n1904 |