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Association of adverse events and quality of life in patients with unresectable hepatocellular carcinoma

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Název: Association of adverse events and quality of life in patients with unresectable hepatocellular carcinoma
Autoři: Ion Agirrezabal, Richard F. Pollock, Phuong Lien Carion, Suki Shergill, Victoria K. Brennan, Helena Pereira, Gilles Chatellier, Valérie Vilgrain
Zdroj: Qual Life Res
Informace o vydavateli: Springer Science and Business Media LLC, 2024.
Rok vydání: 2024
Témata: Male, Principal Component Analysis, Carcinoma, Hepatocellular, Surveys and Questionnaires, Liver Neoplasms, Carcinoma, Hepatocellular/psychology [MeSH], Surveys and Questionnaires [MeSH], Female [MeSH], Aged [MeSH], Humans [MeSH], Hepatocellular carcinoma, Middle Aged [MeSH], Liver Neoplasms/psychology [MeSH], Sorafenib, Selective internal radiation therapy, Adverse events, Article, Quality of life, Male [MeSH], Quality of Life [MeSH], Principal Component Analysis [MeSH], Quality of Life, Humans, Female, Middle Aged, Aged
Popis: Hepatocellular carcinoma (HCC) is the third-leading cause of cancer-related deaths globally. Patients are often diagnosed with advanced disease, in which systemic and locoregional therapies are commonly used as first-line treatment. Such treatments can cause adverse events (AEs) that negatively affect quality of life (QoL), which is particularly undesirable where prognosis is poor. The aim of the present study was to evaluate the impact of common AEs on QoL in patients with HCC.Data from the SARAH randomized controlled trial (RCT) were analyzed. Given the large number of distinct AEs that occurred in the trial, AEs were grouped as in the SARAH trial and prioritized using principal component analysis (PCA). Linear mixed-effects models were then applied with age, ECOG status, and AEs as predictors of the QoL change as measured with the EORTC Core Quality of Life Questionnaire (QLQ-C30).The PCA resulted in the selection of 28 AEs for inclusion in the linear mixed-effects models. Of the 28 AEs, diarrhea, decreased appetite, abdominal pain, and palmar-plantar erythrodysesthesia syndrome (hand-foot syndrome) were significant drivers of reductions in QoL as measured using the QLQ-C30 global health status scale. Diarrhea, abdominal pain, and hand-foot syndrome were also significant drivers of reduced QoL outcomes.The present analysis showed that diarrhea, decreased appetite, abdominal pain, and palmar-plantar erythrodysesthesia were significantly associated with reduced QoL in patients with unresectable HCC. Reducing the incidence and/or severity of these AEs should therefore be a key focus when selecting the optimal treatments for these patients.
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1573-2649
0962-9343
DOI: 10.1007/s11136-024-03779-w
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39412677
https://repository.publisso.de/resource/frl:6522641
Rights: CC BY NC ND
Přístupové číslo: edsair.doi.dedup.....835df315b89810a2e4bc5543f4bd0399
Databáze: OpenAIRE
Popis
Abstrakt:Hepatocellular carcinoma (HCC) is the third-leading cause of cancer-related deaths globally. Patients are often diagnosed with advanced disease, in which systemic and locoregional therapies are commonly used as first-line treatment. Such treatments can cause adverse events (AEs) that negatively affect quality of life (QoL), which is particularly undesirable where prognosis is poor. The aim of the present study was to evaluate the impact of common AEs on QoL in patients with HCC.Data from the SARAH randomized controlled trial (RCT) were analyzed. Given the large number of distinct AEs that occurred in the trial, AEs were grouped as in the SARAH trial and prioritized using principal component analysis (PCA). Linear mixed-effects models were then applied with age, ECOG status, and AEs as predictors of the QoL change as measured with the EORTC Core Quality of Life Questionnaire (QLQ-C30).The PCA resulted in the selection of 28 AEs for inclusion in the linear mixed-effects models. Of the 28 AEs, diarrhea, decreased appetite, abdominal pain, and palmar-plantar erythrodysesthesia syndrome (hand-foot syndrome) were significant drivers of reductions in QoL as measured using the QLQ-C30 global health status scale. Diarrhea, abdominal pain, and hand-foot syndrome were also significant drivers of reduced QoL outcomes.The present analysis showed that diarrhea, decreased appetite, abdominal pain, and palmar-plantar erythrodysesthesia were significantly associated with reduced QoL in patients with unresectable HCC. Reducing the incidence and/or severity of these AEs should therefore be a key focus when selecting the optimal treatments for these patients.
ISSN:15732649
09629343
DOI:10.1007/s11136-024-03779-w