Assessment of in vitro pharmacological effect of Neotropical Piperaceae in GABAergic bioassays in relation to plants traditionally used for folk illness by the Yanesha (Peru)
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| Title: | Assessment of in vitro pharmacological effect of Neotropical Piperaceae in GABAergic bioassays in relation to plants traditionally used for folk illness by the Yanesha (Peru) |
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| Authors: | Picard, G., Valadeau, C., Albán-Castillo, J., Rojas, R., Starr, J.R., Callejas-Posada, R., Bennett, S.A.L., Arnason, J.T. |
| Source: | Journal of Ethnopharmacology. 155:1500-1507 |
| Publisher Information: | Elsevier BV, 2014. |
| Publication Year: | 2014 |
| Subject Terms: | 0301 basic medicine, 0303 health sciences, Epilepsy, GABA-BZD receptor binding, Plant Extracts, Receptors, GABA-A/metabolism, Plant Extracts/pharmacology, Anxiety, Piperaceae, Receptors, GABA-A, 03 medical and health sciences, 4-Aminobutyrate Transaminase/antagonists & inhibitors/metabolism, 4-Aminobutyrate Transaminase, Peru, Biological Assay, Medicine, Traditional, 14. Life underwater, GABA-Transaminase |
| Description: | A previous pilot ethnobotanical and ethnopharmacological study with the Q'echi׳ Maya identified the family Piperaceae, as an important taxonomic group traditionally used for the treatment of epileptic and culture-bound anxiety disorders and possessing activity in the GABA system. Following that lead, a botanical survey was conducted in Peru, where 47 species of Piperaceae were collected including 21 plants traditionally used for folk illnesses by the Yanesha of Peru, an indigenous Amazonian group.Two high throughput bioassays were used to quantify the in vitro activity of botanical extracts on the GABA system.Plant extracts demonstrated moderate to high affinity to the γ-aminobutyric acid benzodiazepine (GABA-BZD) receptor. In addition, extracts demonstrated low to moderate activity in the inhibition of the GABA-transaminase, with select plants exhibiting significant activity. Plants indicated by the Yanesha showed comparable activity to the other Piperaceae plants collected. Piper cremii was the most active plant in the GABA-BZD receptor assay, and Drymaria cordata (Caryophyllaceae) in the GABA-T assay.The study provides evidence that there is a pharmacological basis behind the use of plants in the treatment of susto and mal aire in both Central and South America, and we propose that the possible mechanism of action includes an interaction with the GABA-T enzyme and/or the GABAA-BZD receptor. |
| Document Type: | Article |
| Language: | English |
| ISSN: | 0378-8741 |
| DOI: | 10.1016/j.jep.2014.07.039 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/25091465 http://www.sciencedirect.com/science/article/pii/S0378874114005583 https://www.sciencedirect.com/science/article/pii/S0378874114005583 http://www.ncbi.nlm.nih.gov/pubmed/25091465 https://siis.unmsm.edu.pe/en/publications/assessment-of-in-vitro-pharmacological-effect-of-neotropical-pipe-3 https://pubmed.ncbi.nlm.nih.gov/25091465/ |
| Rights: | Elsevier TDM |
| Accession Number: | edsair.doi.dedup.....83486c2d27b009cd0bf1fae3b0fb31bf |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | A previous pilot ethnobotanical and ethnopharmacological study with the Q'echi׳ Maya identified the family Piperaceae, as an important taxonomic group traditionally used for the treatment of epileptic and culture-bound anxiety disorders and possessing activity in the GABA system. Following that lead, a botanical survey was conducted in Peru, where 47 species of Piperaceae were collected including 21 plants traditionally used for folk illnesses by the Yanesha of Peru, an indigenous Amazonian group.Two high throughput bioassays were used to quantify the in vitro activity of botanical extracts on the GABA system.Plant extracts demonstrated moderate to high affinity to the γ-aminobutyric acid benzodiazepine (GABA-BZD) receptor. In addition, extracts demonstrated low to moderate activity in the inhibition of the GABA-transaminase, with select plants exhibiting significant activity. Plants indicated by the Yanesha showed comparable activity to the other Piperaceae plants collected. Piper cremii was the most active plant in the GABA-BZD receptor assay, and Drymaria cordata (Caryophyllaceae) in the GABA-T assay.The study provides evidence that there is a pharmacological basis behind the use of plants in the treatment of susto and mal aire in both Central and South America, and we propose that the possible mechanism of action includes an interaction with the GABA-T enzyme and/or the GABAA-BZD receptor. |
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| ISSN: | 03788741 |
| DOI: | 10.1016/j.jep.2014.07.039 |