Analysis of the SYSDIET Healthy Nordic Diet randomized trial based on metabolic profiling reveal beneficial effects on glucose metabolism and blood lipids
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| Titel: | Analysis of the SYSDIET Healthy Nordic Diet randomized trial based on metabolic profiling reveal beneficial effects on glucose metabolism and blood lipids |
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| Autoren: | Gürdeniz, Gözde, Uusitupa, Matti, Hermansen, Kjeld, Savolainen, Markku J., Schwab, Ursula, Kolehmainen, Marjukka, Brader, Lea, Cloetens, Lieselotte, Herzig, Karl Heinz, Hukkanen, Janne, Rosqvist, Fredrik, Ulven, Stine Marie, Gunnarsdóttir, Ingibjörg, Thorsdottir, Inga, Orešič, Matej, Poutanen, Kaisa S., Risérus, Ulf, Åkesson, Björn, Dragsted, Lars Ove |
| Quelle: | Gürdeniz, G, Uusitupa, M, Hermansen, K, Savolainen, M J, Schwab, U, Kolehmainen, M, Brader, L J, Cloetens, L, Herzig, K-H, Hukkanen, J, Rosqvist, F, Ulven, S M, Gunnarsdóttir, I, Thorsdottir, I, Orešič, M, Poutanen, K S, Risérus, U, Åkesson, B & Dragsted, L O 2022, ' Analysis of the SYSDIET Healthy Nordic Diet randomized trial based on metabolic profiling reveal beneficial effects on glucose metabolism and blood lipids ', Clinical Nutrition, vol. 41, no. 2, pp. 441-451 . https://doi.org/10.1016/j.clnu.2021.12.031 Gürdeniz, G, Uusitupa, M, Hermansen, K, Savolainen, M J, Schwab, U, Kolehmainen, M, Brader, L, Cloetens, L, Herzig, K H, Hukkanen, J, Rosqvist, F, Ulven, S M, Gunnarsdóttir, I, Thorsdottir, I, Oresic, M, Poutanen, K S, Risérus, U, Åkesson, B & Dragsted, L O 2022, 'Analysis of the SYSDIET Healthy Nordic Diet randomized trial based on metabolic profiling reveal beneficial effects on glucose metabolism and blood lipids', Clinical Nutrition, vol. 41, no. 2, pp. 441-451. https://doi.org/10.1016/j.clnu.2021.12.031 |
| Verlagsinformationen: | Elsevier BV, 2022. |
| Publikationsjahr: | 2022 |
| Schlagwörter: | Blood Glucose, Male, 0301 basic medicine, Fasting/blood, Overweight/complications, Glucose and lipid metabolism, Eating, Healthy Nordic diet, Faculty of Science, Randomized Controlled Trials as Topic, Eating/physiology, Metabolic Syndrome, 2. Zero hunger, Principal Component Analysis, 0303 health sciences, Nutrition and Dietetics, LC–MS metabolomics, ta3141, Fasting, Middle Aged, Lipids, 6. Clean water, 3. Good health, Näringslära, Triglycerides/blood, Randomized controlled trial, Inflammation Mediators/blood, Area Under Curve, name=Faculty of Science, Female, Diet, Healthy, Inflammation Mediators, Näringslära och dietkunskap, Lipoproteins, Scandinavian and Nordic Countries, ta3111, 03 medical and health sciences, Lipoproteins/blood, Metabolomics/methods, Humans, Metabolomics, Blood Glucose/metabolism, Lipids/blood, Cardiometabolic Risk Factors, ta3121, Plasma metabolite scores, Overweight, LC-MS metabolomics, Metabolic Syndrome/complications, Nutrition Assessment, Biomarkers/blood, Diet, Healthy/methods, Biomarkers |
| Beschreibung: | Intake assessment in multicenter trials is challenging, yet important for accurate outcome evaluation. The present study aimed to characterize a multicenter randomized controlled trial with a healthy Nordic diet (HND) compared to a Control diet (CD) by plasma and urine metabolic profiles and to associate them with cardiometabolic markers.During 18-24 weeks of intervention, 200 participants with metabolic syndrome were advised at six centres to eat either HND (e.g. whole-grain products, berries, rapeseed oil, fish and low-fat dairy) or CD while being weight stable. Of these 166/159 completers delivered blood/urine samples. Metabolic profiles of fasting plasma and 24 h pooled urine were analysed to identify characteristic diet-related patterns. Principal components analysis (PCA) scores (i.e. PC1 and PC2 scores) were used to test their combined effect on blood glucose response (primary endpoint), serum lipoproteins, triglycerides, and inflammatory markers.The profiles distinguished HND and CD with AUC of 0.96 ± 0.03 and 0.93 ± 0.02 for plasma and urine, respectively, with limited heterogeneity between centers, reflecting markers of key foods. Markers of fish, whole grain and polyunsaturated lipids characterized HND, while CD was reflected by lipids containing palmitoleic acid. The PC1 scores of plasma metabolites characterizing the intervention is associated with HDL (β = 0.05; 95% CI: 0.02, 0.08; P = 0.001) and triglycerides (β = -0.06; 95% CI: -0.09, -0.03; P |
| Publikationsart: | Article |
| Dateibeschreibung: | application/pdf |
| Sprache: | English |
| ISSN: | 0261-5614 |
| DOI: | 10.1016/j.clnu.2021.12.031 |
| Zugangs-URL: | http://www.clinicalnutritionjournal.com/article/S0261561421005963/pdf https://pubmed.ncbi.nlm.nih.gov/35007813 https://cris.vtt.fi/en/publications/7f5e9df4-9375-40eb-a062-4676193c74ee https://doi.org/10.1016/j.clnu.2021.12.031 http://hdl.handle.net/10852/98532 https://doi.org/10.1016/j.clnu.2021.12.031 http://urn.fi/urn:nbn:fi-fe2022061647006 https://curis.ku.dk/ws/files/289168321/Gurdeniz_et_al_Clinical_Nutrition_2022_Vol_11_2_441_451.pdf http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-469771 http://www.scopus.com/inward/record.url?scp=85122434050&partnerID=8YFLogxK https://pure.au.dk/portal/en/publications/cee2ba64-80f1-44a4-8cad-b4b1753af5c9 https://doi.org/10.1016/j.clnu.2021.12.031 |
| Rights: | CC BY |
| Dokumentencode: | edsair.doi.dedup.....831e24d84a7799f66ef5c2ad3c32aed9 |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Intake assessment in multicenter trials is challenging, yet important for accurate outcome evaluation. The present study aimed to characterize a multicenter randomized controlled trial with a healthy Nordic diet (HND) compared to a Control diet (CD) by plasma and urine metabolic profiles and to associate them with cardiometabolic markers.During 18-24 weeks of intervention, 200 participants with metabolic syndrome were advised at six centres to eat either HND (e.g. whole-grain products, berries, rapeseed oil, fish and low-fat dairy) or CD while being weight stable. Of these 166/159 completers delivered blood/urine samples. Metabolic profiles of fasting plasma and 24 h pooled urine were analysed to identify characteristic diet-related patterns. Principal components analysis (PCA) scores (i.e. PC1 and PC2 scores) were used to test their combined effect on blood glucose response (primary endpoint), serum lipoproteins, triglycerides, and inflammatory markers.The profiles distinguished HND and CD with AUC of 0.96 ± 0.03 and 0.93 ± 0.02 for plasma and urine, respectively, with limited heterogeneity between centers, reflecting markers of key foods. Markers of fish, whole grain and polyunsaturated lipids characterized HND, while CD was reflected by lipids containing palmitoleic acid. The PC1 scores of plasma metabolites characterizing the intervention is associated with HDL (β = 0.05; 95% CI: 0.02, 0.08; P = 0.001) and triglycerides (β = -0.06; 95% CI: -0.09, -0.03; P |
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| ISSN: | 02615614 |
| DOI: | 10.1016/j.clnu.2021.12.031 |