A versatile stereocontrolled synthesis of 2-deoxyiminosugar C-glycosides and their evaluation as glycosidase inhibitors
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| Název: | A versatile stereocontrolled synthesis of 2-deoxyiminosugar C-glycosides and their evaluation as glycosidase inhibitors |
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| Autoři: | Alexandre Lumbroso, Clément Berthonneau, Isabelle Beaudet, Jean-Paul Quintard, Aurélien Planchat, M. Isabel García-Moreno, Carmen Ortiz Mellet, Erwan Le Grognec |
| Přispěvatelé: | Universidad de Sevilla. Departamento de Química orgánica, Institut de Chimie des Substances Naturelles (ICSN). France, Ministère de l'Enseignement Supérieur, de la Recherche et de l’Innovation (MESRI). France, Université de Rennes. France, Ministerio de Ciencia e Innovación (MICIN). España, Agencia Estatal de Investigación. España, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER), Catalysis, ORganometallic chemistry And synthesIs of Ligands ( CORAIL), Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| Zdroj: | idUS. Depósito de Investigación de la Universidad de Sevilla Universidad de Sevilla (US) |
| Informace o vydavateli: | Royal Society of Chemistry (RSC), 2021. |
| Rok vydání: | 2021 |
| Témata: | Models, Molecular, Molecular Stereoisomerism, Glycoside Hydrolases, Stereoisomerism, Chemistry Techniques, Synthetic, MESH: Carbohydrate Conformation Chemistry Techniques, 01 natural sciences, Imino Sugars, 3. Good health, 0104 chemical sciences, Synthetic Enzyme Inhibitors / chemical synthesis* Enzyme Inhibitors / chemistry Enzyme Inhibitors / pharmacology* Glycoside Hydrolases / antagonists & inhibitors* Glycosides / chemical synthesis* Glycosides / chemistry Glycosides / pharmacology* Imino Sugars / chemistry* Models, C-glycoside, 13. Climate action, Carbohydrate Conformation, [CHIM]Chemical Sciences, Glycosides, Enzyme Inhibitors |
| Popis: | Dihydroxylation of (R,S) or (S,S)-2,6-disubstituted dehydropiperidines enantioselectively obtained from stannylated precursors allows a versatile preparation of 2-deoxyiminosugar C-glycosides which have been evaluated as glycosidases inhibitors. |
| Druh dokumentu: | Article |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1477-0539 1477-0520 |
| DOI: | 10.1039/d0ob02249g |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/33427829 https://hdl.handle.net/11441/141423 https://hal.archives-ouvertes.fr/hal-03376475 http://pubs.rsc.org/en/content/articlelanding/2021/ob/d0ob02249g http://www.ncbi.nlm.nih.gov/pubmed/33427829 https://crystallography.net/cod/7157828.html https://pubs.rsc.org/en/content/articlelanding/2021/ob/d0ob02249g https://www.ncbi.nlm.nih.gov/pubmed/33427829 https://idus.us.es/handle//11441/141423 |
| Rights: | Royal Society of Chemistry Licence to Publish CC BY NC ND |
| Přístupové číslo: | edsair.doi.dedup.....81f7d08bfb233a3d16e4bf48692fb1e3 |
| Databáze: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | Dihydroxylation of (R,S) or (S,S)-2,6-disubstituted dehydropiperidines enantioselectively obtained from stannylated precursors allows a versatile preparation of 2-deoxyiminosugar C-glycosides which have been evaluated as glycosidases inhibitors. |
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| ISSN: | 14770539 14770520 |
| DOI: | 10.1039/d0ob02249g |