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Association of insulin resistance with cardiovascular disease and all-cause mortality in type 1 diabetes: systematic review and meta-analysis

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Názov: Association of insulin resistance with cardiovascular disease and all-cause mortality in type 1 diabetes: systematic review and meta-analysis
Autori: Rui Sun, Jianxin Wang, Meng Li, Jingen Li, Yi Pan, Birong Liu, Gregory Y.H. Lip, Lijing Zhang
Zdroj: Sun, R, Wang, J, Li, M, Li, J, Pan, Y, Liu, B, Lip, G Y H & Zhang, L 2024, 'Association of Insulin Resistance With Cardiovascular Disease and All-Cause Mortality in Type 1 Diabetes: Systematic Review and Meta-analysis', Diabetes Care, vol. 47, no. 12, dc240475, pp. 2266-2274. https://doi.org/10.2337/dc24-0475
Informácie o vydavateľovi: American Diabetes Association, 2024.
Rok vydania: 2024
Predmety: 03 medical and health sciences, Diabetes Mellitus, Type 1, 0302 clinical medicine, Cardiovascular Diseases, Humans, Diabetes Mellitus, Type 1/mortality, Insulin Resistance, Cardiovascular Diseases/mortality, Insulin Resistance/physiology, 3. Good health
Popis: Background: The association of insulin resistance (IR) with cardiovascular disease (CVD) and all-cause mortality in type 1 diabetes (T1D) remains unclear.Purpose: To investigate whether IR is associated with CVD and all-cause mortality among individuals with T1D. Data Sources: PubMed, EMBASE, and the Cochrane Library databases were searched from inception to 31 October 2023.Study Selection: Observational studies reporting the associations between IR, as calculated by estimated glucose disposal rate (eGDR), and the risk of CVD and all-cause mortality in individuals with T1D were eligible for inclusion. Data Extraction: Data from 8 selected studies were extracted, pooled by random- effects models, and results were presented as hazard ratios (95% CI).Data Synthesis: Eight studies involving 21,930 individuals were included, of which 5 studies involving 19,960 T1D individuals reported the risk of CVD. During a median follow-up of 10 years, there were 2,149 cases of incident CVD. The pooled hazard ratio for composite CVD outcome per 1-unit increase in the eGDR index was 0.83 (95% CI 0.78–0.90, I2 = 58.9%). Five studies involving 19,403 T1D individuals reported the risk of all-cause mortality. During a median follow-up of 10 years, 1,279 deaths were observed. The pooled hazard ratio for all-cause mortality per 1-unit increase in the eGDR index was 0.84 (95% CI 0.81–0.87, I2 = 0%).Limitations: The small number of available studies restricted our ability to perform meta-regression analyses or more detailed subgroup analyses.Conclusions: IR, as calculated by eGDR, may be an additional risk factor for CVD and all-cause mortality in T1D.
Druh dokumentu: Article
ISSN: 1935-5548
0149-5992
DOI: 10.2337/figshare.26083753
DOI: 10.2337/dc24-0475
DOI: 10.2337/figshare.26083753.v1
Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/39018337
https://vbn.aau.dk/da/publications/31bc6082-54a1-4f72-b8cf-2dbfa8444f18
https://doi.org/10.2337/dc24-0475
Rights: CC BY NC SA
URL: https://www.diabetesjournals.org/journals/pages/license
Prístupové číslo: edsair.doi.dedup.....81c883d5420f0e5dd08d0ab6d13b4101
Databáza: OpenAIRE
Popis
Abstrakt:Background: The association of insulin resistance (IR) with cardiovascular disease (CVD) and all-cause mortality in type 1 diabetes (T1D) remains unclear.Purpose: To investigate whether IR is associated with CVD and all-cause mortality among individuals with T1D. Data Sources: PubMed, EMBASE, and the Cochrane Library databases were searched from inception to 31 October 2023.Study Selection: Observational studies reporting the associations between IR, as calculated by estimated glucose disposal rate (eGDR), and the risk of CVD and all-cause mortality in individuals with T1D were eligible for inclusion. Data Extraction: Data from 8 selected studies were extracted, pooled by random- effects models, and results were presented as hazard ratios (95% CI).Data Synthesis: Eight studies involving 21,930 individuals were included, of which 5 studies involving 19,960 T1D individuals reported the risk of CVD. During a median follow-up of 10 years, there were 2,149 cases of incident CVD. The pooled hazard ratio for composite CVD outcome per 1-unit increase in the eGDR index was 0.83 (95% CI 0.78–0.90, I2 = 58.9%). Five studies involving 19,403 T1D individuals reported the risk of all-cause mortality. During a median follow-up of 10 years, 1,279 deaths were observed. The pooled hazard ratio for all-cause mortality per 1-unit increase in the eGDR index was 0.84 (95% CI 0.81–0.87, I2 = 0%).Limitations: The small number of available studies restricted our ability to perform meta-regression analyses or more detailed subgroup analyses.Conclusions: IR, as calculated by eGDR, may be an additional risk factor for CVD and all-cause mortality in T1D.
ISSN:19355548
01495992
DOI:10.2337/figshare.26083753