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The genetic versus pharmacological invalidation of the cannabinoid CB1 receptor results in differential effects on ‘non-associative’ memory and forebrain monoamine concentrations in mice

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Název: The genetic versus pharmacological invalidation of the cannabinoid CB1 receptor results in differential effects on ‘non-associative’ memory and forebrain monoamine concentrations in mice
Autoři: Thiemann, Gunnar, Fletcher, Ben C, Ledent, Catherine, Molleman, Areles, Hasenöhrl, Rüdiger U
Zdroj: Neurobiology of Learning and Memory. 88:416-423
Informace o vydavateli: Elsevier BV, 2007.
Rok vydání: 2007
Témata: Serotonin, CB1 -- physiology, CB1 -- genetics, Biogenic amines, Knockout, Neural Inhibition -- drug effects, Cerebral Cortex -- metabolism, Inbred Strains, Piperidines -- pharmacology, CB1-knockout, Mice, Inbred Strains, Psychophysiologic -- drug effects, Hippocampus, Statistics, Nonparametric, Association Learning -- physiology, Mice, 03 medical and health sciences, 0302 clinical medicine, Piperidines, Receptor, Cannabinoid, CB1, Hippocampus -- drug effects, Animals, Nonparametric, Hippocampus -- metabolism, CB1 -- antagonists & inhibitors, Habituation, Psychophysiologic, Cannabinoid, Pyrazoles -- pharmacology, Cerebral Cortex, Mice, Knockout, Analysis of Variance, Psychophysiologic -- physiology, Statistics, Association Learning, Neural Inhibition, Sciences bio-médicales et agricoles, Exploratory Behavior -- physiology, Exploratory Behavior -- drug effects, Serotonin -- metabolism, Neural Inhibition -- physiology, Cerebral Cortex -- drug effects, Exploratory Behavior, CB1 -- classification, Pyrazoles, Association Learning -- drug effects, Habituation, Rimonabant, Receptor
Popis: The endocannabinoid CB(1) receptor has been implicated in the inhibitory control of learning and memory. In the present experiment, we compared the behavioral response of CB(1) receptor knockout mice (CB(1)R(-/-)) with animals administered CB(1) receptor antagonist/inverse agonist SR141716A (rimonabant; 3 mg/kg IP, 30 min pre-trial) in terms of acquisition and retention of a habituation task and changes in cerebral monoamines. The results can be summarized as follows: (i) the acute and chronic invalidation of the CB(1) receptor resulted in an increase of behavioral habituation during the first exposure to an open field, indicative of enhanced acquisition of the task; (ii) CB(1)R(-/-) mice, but not rimonabant-treated animals, showed enhanced retention of the habituation task when re-tested 48 h and 1 week subsequent to the first exposure to the open field, respectively; (iii) the facilitation of retention of the habituation task in CB(1)R(-/-) mice was accompanied by a selective and site-specific increase in serotonin activity in hippocampus; and (iv) rimonabant-treated animals displayed 'antidepressant-like' neurochemical alterations of cerebral monoamines, that is, most parameters of monoaminergic activity were increased especially in dorsal striatum and hippocampus. Taken together, the present findings demonstrate that the genetic disruption of the CB(1) receptor gene can cause an improvement of behavioral habituation, which is considered to represent a form of 'non-associative' learning. Furthermore, our data support the assumption of a rimonabant-sensitive cannabinoid receptive site that is different from the 'classical' CB(1) receptor and which, under physiological conditions, might be involved in the inhibitory control of the acquisition but not retention of non-associative learning tasks.
Druh dokumentu: Article
Popis souboru: 1 full-text file(s): application/pdf
Jazyk: English
ISSN: 1074-7427
DOI: 10.1016/j.nlm.2007.07.013
Přístupová URL adresa: http://uhra.herts.ac.uk/bitstream/2299/2005/1/901120.pdf
https://pubmed.ncbi.nlm.nih.gov/17884611
https://core.ac.uk/display/1638124
https://www.ncbi.nlm.nih.gov/pubmed/17884611
https://uhra.herts.ac.uk/handle/2299/2005?show=full
https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/54675/Details
https://www.sciencedirect.com/science/article/pii/S1074742707001165
Rights: Elsevier TDM
Přístupové číslo: edsair.doi.dedup.....80e7be44157366db4204b1239cfc186b
Databáze: OpenAIRE
Popis
Abstrakt:The endocannabinoid CB(1) receptor has been implicated in the inhibitory control of learning and memory. In the present experiment, we compared the behavioral response of CB(1) receptor knockout mice (CB(1)R(-/-)) with animals administered CB(1) receptor antagonist/inverse agonist SR141716A (rimonabant; 3 mg/kg IP, 30 min pre-trial) in terms of acquisition and retention of a habituation task and changes in cerebral monoamines. The results can be summarized as follows: (i) the acute and chronic invalidation of the CB(1) receptor resulted in an increase of behavioral habituation during the first exposure to an open field, indicative of enhanced acquisition of the task; (ii) CB(1)R(-/-) mice, but not rimonabant-treated animals, showed enhanced retention of the habituation task when re-tested 48 h and 1 week subsequent to the first exposure to the open field, respectively; (iii) the facilitation of retention of the habituation task in CB(1)R(-/-) mice was accompanied by a selective and site-specific increase in serotonin activity in hippocampus; and (iv) rimonabant-treated animals displayed 'antidepressant-like' neurochemical alterations of cerebral monoamines, that is, most parameters of monoaminergic activity were increased especially in dorsal striatum and hippocampus. Taken together, the present findings demonstrate that the genetic disruption of the CB(1) receptor gene can cause an improvement of behavioral habituation, which is considered to represent a form of 'non-associative' learning. Furthermore, our data support the assumption of a rimonabant-sensitive cannabinoid receptive site that is different from the 'classical' CB(1) receptor and which, under physiological conditions, might be involved in the inhibitory control of the acquisition but not retention of non-associative learning tasks.
ISSN:10747427
DOI:10.1016/j.nlm.2007.07.013