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Versteckte Vielfalt: Diversität von Zellen im industriellen Bioprozess

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Bibliographic Details
Title:	Versteckte Vielfalt: Diversität von Zellen im industriellen Bioprozess
Authors:	Arulrajah, Prasika, Heins, Anna-Lena
Source:	BIOspektrum. 29:241-244
Publisher Information:	Springer Science and Business Media LLC, 2023.
Publication Year:	2023
Subject Terms:	Wissenschaft, Life Sciences, general, Biochemistry, general, Human Genetics, Microbiology, Pharmacology/Toxicology, ddc
Description:	Population heterogeneity poses a major challenge in industrial scale bioprocesses, affecting process performance but also leading to more robust phenotypes. To investigate this phenomenon, multiple fluorescent reporter strains are cultivated under simulated industrial scale conditions in multi-compartment bioreactors. This approach significantly raises the quantitative understanding of population heterogenity which is needed before its benefits can help to develop high-yielding, more robust bioprocesses.
Document Type:	Article
File Description:	application/pdf
Language:	German
ISSN:	1868-6249 0947-0867
DOI:	10.1007/s12268-023-1922-y
DOI:	10.15480/882.8093
Access URL:	https://mediatum.ub.tum.de/1763577
Rights:	CC BY
Accession Number:	edsair.doi.dedup.....802b1c8b21b480126b31d5f9f5141ab6
Database:	OpenAIRE

Description
Abstract:	Population heterogeneity poses a major challenge in industrial scale bioprocesses, affecting process performance but also leading to more robust phenotypes. To investigate this phenomenon, multiple fluorescent reporter strains are cultivated under simulated industrial scale conditions in multi-compartment bioreactors. This approach significantly raises the quantitative understanding of population heterogenity which is needed before its benefits can help to develop high-yielding, more robust bioprocesses.
ISSN:	18686249 09470867
DOI:	10.1007/s12268-023-1922-y