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A new hematologic predictor of major adverse events after cardiac surgery: red cell distribution width to lymphocyte ratio

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Title: A new hematologic predictor of major adverse events after cardiac surgery: red cell distribution width to lymphocyte ratio
Authors: Seda Kurtbeyoğlu, Aslı Demir, Eda Balcı, Hülya Yiğit Özay, Bilal Katipoğlu, Hayrettin Levent Mavioğlu
Source: Anesth Pain Med (Seoul)
Anesthesia and Pain Medicine, Vol 18, Iss 3, Pp 284-289 (2023)
Publisher Information: The Korean Society of Anesthesiologists, 2023.
Publication Year: 2023
Subject Terms: preoperative blood counts, inflammatory and immune imbalances, erythrocyte indices, Anesthesiology, Medicine, RD78.3-87.3, blood cell count, cardiac surgical procedures, Cardiothoracic and Vascular Anesthesia, 3. Good health
Description: Background: The perioperative risk factors that cause severe morbidity and prolongation of postoperative hospital stay after cardiac surgery should be determined. Various scores have been used to predict morbidity and mortality. Preoperative blood counts are considered potential biomarkers of inflammation and oxidative stress. Inflammatory and immune imbalances may have a significant impact on postoperative adverse events. The present study aimed to investigate the association and potential predictive properties of red cell distribution width/ lymphocyte ratio (RLR) for major adverse events in adult patients who underwent coronary surgery with cardiopulmonary bypass.Methods: After approval from the ethics committee, pre- and post-operative data of 700 patients were obtained from the electronic database of the hospital, intra- and post-operative anesthesia, and intensive care unit follow-up charts. We performed a stepwise multiple logistic regression analysis to investigate the association of RLR with major adverse events in adult patients who underwent coronary surgery with cardiopulmonary bypass.Results: Among 700 patients, 47 (6.7%) had major adverse events after surgery. Multivariate logistic regression analysis showed that age (odds ratio [OR], 1.08; 95% confidence interval [CI], 1.03–1.12; P < 0.001), mean platelet volume (OR, 1.49; 95% CI, 1.07–2.06; P = 0.017), and RLR (OR, 1.21; 95% CI, 1.02–1.43; P = 0.026) were significantly associated with major adverse events.Conclusions: RLR indicates the balance between inflammatory and immune responses. Therefore, it can be used to predict adverse events following coronary surgery.
Document Type: Article
Other literature type
Language: English
ISSN: 2383-7977
1975-5171
DOI: 10.17085/apm.22244
Access URL: https://pubmed.ncbi.nlm.nih.gov/37468199
https://doaj.org/article/39e696e765c640e9a324803611de54f4
Rights: CC BY NC
Accession Number: edsair.doi.dedup.....7f430aca9874602be11bf5b0c078d13b
Database: OpenAIRE
Description
Abstract:Background: The perioperative risk factors that cause severe morbidity and prolongation of postoperative hospital stay after cardiac surgery should be determined. Various scores have been used to predict morbidity and mortality. Preoperative blood counts are considered potential biomarkers of inflammation and oxidative stress. Inflammatory and immune imbalances may have a significant impact on postoperative adverse events. The present study aimed to investigate the association and potential predictive properties of red cell distribution width/ lymphocyte ratio (RLR) for major adverse events in adult patients who underwent coronary surgery with cardiopulmonary bypass.Methods: After approval from the ethics committee, pre- and post-operative data of 700 patients were obtained from the electronic database of the hospital, intra- and post-operative anesthesia, and intensive care unit follow-up charts. We performed a stepwise multiple logistic regression analysis to investigate the association of RLR with major adverse events in adult patients who underwent coronary surgery with cardiopulmonary bypass.Results: Among 700 patients, 47 (6.7%) had major adverse events after surgery. Multivariate logistic regression analysis showed that age (odds ratio [OR], 1.08; 95% confidence interval [CI], 1.03–1.12; P < 0.001), mean platelet volume (OR, 1.49; 95% CI, 1.07–2.06; P = 0.017), and RLR (OR, 1.21; 95% CI, 1.02–1.43; P = 0.026) were significantly associated with major adverse events.Conclusions: RLR indicates the balance between inflammatory and immune responses. Therefore, it can be used to predict adverse events following coronary surgery.
ISSN:23837977
19755171
DOI:10.17085/apm.22244