Synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization
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| Title: | Synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization |
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| Authors: | Danielle R. Donahue, Young-Seung Kim, Gert Storm, Quentin Boffi, William F. Pritchard, Ayele H. Negussie, Chrit T. W. Moonen, Quirina M.B. de Ruiter, Hugh Britton, Bradford J. Wood, Andrew L. Lewis |
| Contributors: | Researchgr. Beeldg. Moleculaire Interv., Regenerative Medicine and Stem Cells, Cancer, Afd Pharmaceutics, Pharmaceutics, SURGERY |
| Source: | Sci Rep Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
| Publisher Information: | Springer Science and Business Media LLC, 2021. |
| Publication Year: | 2021 |
| Subject Terms: | Hepatocellular/blood supply, Carcinoma, Hepatocellular, Science, Tomography, X-Ray Computed/methods, Contrast Media, Article, Embolization, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Journal Article, General, Contrast Media/chemical synthesis, Tomography, Iodine/chemistry, Bismuth/chemistry, Carcinoma, Liver Neoplasms, Carcinoma, Hepatocellular/blood supply, Liver Neoplasms/blood supply, Embolization, Therapeutic, X-Ray Computed/methods, Microspheres, 3. Good health, Medicine, Embolization, Therapeutic/methods, Tomography, X-Ray Computed, Therapeutic/methods, Bismuth, Iodine |
| Description: | Current therapy for hypervascular cancers, e.g., hepatocellular carcinoma, includes occlusion of the tumor blood supply by arterial infusion of embolic microspheres (beads) suspended in iodine-based contrast under fluoroscopic guidance. Available radiopaque, imageable beads use iodine as the radiopacifier and cannot be differentiated from contrast. This study aimed to synthesize and characterize imageable beads using bismuth as the radiopacifier that could be distinguished from iodine contrast based upon the difference in the binding energy of k-shell electrons (k-edge). Radiodense bismuth beads were successfully synthesized some with uniform bismuth distribution across the beads. The beads were spherical and could be infused through clinical microcatheters. The bismuth beads could be imaged with clinical dual-energy computed tomography (CT), where iodine-based contrast could be distinguished from the microspheres. The ability to separate iodine from bismuth may enhance the diagnostic information acquired on follow-up CT, identifying the distribution of the embolic beads separately from the contrast. Furthermore, with sequential use of iodine- and bismuth-based beads, the two radiopaque beads could be spatially distinguished on imaging, which may enable the development of dual drug delivery and dual tracking. |
| Document Type: | Article Other literature type |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-79900-z |
| Access URL: | https://www.nature.com/articles/s41598-020-79900-z.pdf https://pubmed.ncbi.nlm.nih.gov/33436734 https://doaj.org/article/5c8343e6e7924265820253b48addecee https://research.utwente.nl/en/publications/5a4b5d1d-6646-45f7-9037-1fb54023916e https://doi.org/10.1038/s41598-020-79900-z https://research-portal.uu.nl/en/publications/af0fed61-3737-4a0c-bd04-9dbadb8ca36f https://doi.org/10.1038/s41598-020-79900-z https://pubmed.ncbi.nlm.nih.gov/33436734/ https://www.nature.com/articles/s41598-020-79900-z.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804415 https://research.utwente.nl/en/publications/synthesis-characterization-and-imaging-of-radiopaque-bismuth-bead https://www.nature.com/articles/s41598-020-79900-z https://www.narcis.nl/publication/RecordID/oai%3Aris.utwente.nl%3Apublications%2F5a4b5d1d-6646-45f7-9037-1fb54023916e https://dspace.library.uu.nl/handle/1874/441959 https://dspace.library.uu.nl/handle/1874/419440 https://dspace.library.uu.nl/handle/1874/418115 |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....7e85a03ee17fd3d9489ad8d2330b83ef |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Current therapy for hypervascular cancers, e.g., hepatocellular carcinoma, includes occlusion of the tumor blood supply by arterial infusion of embolic microspheres (beads) suspended in iodine-based contrast under fluoroscopic guidance. Available radiopaque, imageable beads use iodine as the radiopacifier and cannot be differentiated from contrast. This study aimed to synthesize and characterize imageable beads using bismuth as the radiopacifier that could be distinguished from iodine contrast based upon the difference in the binding energy of k-shell electrons (k-edge). Radiodense bismuth beads were successfully synthesized some with uniform bismuth distribution across the beads. The beads were spherical and could be infused through clinical microcatheters. The bismuth beads could be imaged with clinical dual-energy computed tomography (CT), where iodine-based contrast could be distinguished from the microspheres. The ability to separate iodine from bismuth may enhance the diagnostic information acquired on follow-up CT, identifying the distribution of the embolic beads separately from the contrast. Furthermore, with sequential use of iodine- and bismuth-based beads, the two radiopaque beads could be spatially distinguished on imaging, which may enable the development of dual drug delivery and dual tracking. |
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| ISSN: | 20452322 |
| DOI: | 10.1038/s41598-020-79900-z |