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Alteration of glucose metabolism and expression of glucose transporters in ovarian cancer

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Title: Alteration of glucose metabolism and expression of glucose transporters in ovarian cancer
Authors: Faris Ali, Zineb Qmichou, Mohamed Oukabli, Nadia Dakka, Youssef Bakri, Mohamed Eddouks, Rabii Ameziane El Hassani
Source: Explor Target Antitumor Ther
Exploration of Targeted Anti-tumor Therapy, Vol 5, Iss 2, Pp 384-399 (2024)
Publisher Information: Open Exploration Publishing, 2024.
Publication Year: 2024
Subject Terms: 0301 basic medicine, chemotherapy resistance, Cancer Research, Glucose uptake, Cancer cell, Review, Cancer research, Tumor cells, Metastasis, 12. Responsible consumption, 03 medical and health sciences, Endocrinology, Cancer Progression, Ovarian cancer, Biochemistry, Genetics and Molecular Biology, Genetics, Insulin, glucose transporters, Anaerobic glycolysis, aerobic glycolysis, Internal medicine, Molecular Biology, Biology, Glucose transporter, Cancer, 2. Zero hunger, 0303 health sciences, Glucose Transporter Type 1, prognosis biomarker, Life Sciences, Role of AMP-Activated Protein Kinase in Cellular Metabolism, RC31-1245, Glutamine Metabolism, 3. Good health, Glycogen Metabolism, ovarian cancer, Metabolism, Tumor microenvironment, RNA Methylation and Modification in Gene Expression, FOS: Biological sciences, Cancer Cell Metabolism, Metabolic Reprogramming in Cancer Biology, Warburg effect, Glycolysis, diagnosis biomarker, GLUT1, Warburg Effect
Description: Aerobic glycolysis also known as the Warburg effect, remains a hallmark of various cancers, including ovarian cancer. Cancer cells undergo metabolic changes to sustain their tumorigenic properties and adapt to environmental conditions, such as hypoxia and nutrient starvation. Altered metabolic pathways not only facilitate ovarian cancer cells’ survival and proliferation but also endow them to metastasize, develop resistance to chemotherapy, maintain cancer stem cell phenotype, and escape anti-tumor immune responses. Glucose transporters (GLUTs), which play a pivotal role as the rate-limiting step in glycolysis, are frequently overexpressed in a variety of tumors, including ovarian cancer. Multiple oncoproteins can regulate GLUT proteins, promoting tumor proliferation, migration, and metastasis, either dependent or independent of glycolysis. This review examines the alteration of GLUT proteins, particularly GLUT1, in ovarian cancer and its impact on cancer initiation, progression, and resistance to treatment. Additionally, it highlights the role of these proteins as biomarkers for diagnosis and prognosis in ovarian cancer, and delves into novel therapeutic strategies currently under development that target GLUT isoforms.
Document Type: Article
Other literature type
ISSN: 2692-3114
DOI: 10.37349/etat.2024.00224
DOI: 10.60692/70d9e-fma16
DOI: 10.60692/2s37e-8sa43
Access URL: https://pubmed.ncbi.nlm.nih.gov/38745772
https://doaj.org/article/099e42bfab6f4ba491db39943b0b31bd
Rights: URL: https://doi.org/10.37349/Open_Exploration_Crossmark_Policy
URL: http://creativecommons.org/licenses/by/4.0/This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Accession Number: edsair.doi.dedup.....7de6042e6910cb6d97eebf80356d2250
Database: OpenAIRE
Description
Abstract:Aerobic glycolysis also known as the Warburg effect, remains a hallmark of various cancers, including ovarian cancer. Cancer cells undergo metabolic changes to sustain their tumorigenic properties and adapt to environmental conditions, such as hypoxia and nutrient starvation. Altered metabolic pathways not only facilitate ovarian cancer cells’ survival and proliferation but also endow them to metastasize, develop resistance to chemotherapy, maintain cancer stem cell phenotype, and escape anti-tumor immune responses. Glucose transporters (GLUTs), which play a pivotal role as the rate-limiting step in glycolysis, are frequently overexpressed in a variety of tumors, including ovarian cancer. Multiple oncoproteins can regulate GLUT proteins, promoting tumor proliferation, migration, and metastasis, either dependent or independent of glycolysis. This review examines the alteration of GLUT proteins, particularly GLUT1, in ovarian cancer and its impact on cancer initiation, progression, and resistance to treatment. Additionally, it highlights the role of these proteins as biomarkers for diagnosis and prognosis in ovarian cancer, and delves into novel therapeutic strategies currently under development that target GLUT isoforms.
ISSN:26923114
DOI:10.37349/etat.2024.00224