Dysfunction of PSA-specific CD8+ T cells in prostate cancer patients correlates with CD38 and Tim-3 expression
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| Title: | Dysfunction of PSA-specific CD8+ T cells in prostate cancer patients correlates with CD38 and Tim-3 expression |
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| Authors: | Ahmed Magheli, Marco Frentsch, Christian Klopf, Andreas Thiel, Xiangdong Li, Alberto Sada Japp, Hans Krause, M. Alper Kursunel, Waltraut Jekabsons, Julia Nora Mälzer, Sarah Meier, Nafis A. Rahman |
| Source: | Cancer Immunology, Immunotherapy. 64:1487-1494 |
| Publisher Information: | Springer Science and Business Media LLC, 2015. |
| Publication Year: | 2015 |
| Subject Terms: | Male, Prostatic neoplasms - immunology, CD8-Positive T-Lymphocytes, ta3111, ADP-ribosyl cyclase 1 - analysis, 03 medical and health sciences, 0302 clinical medicine, Prostatic neoplasms - therapy, Humans, Middle aged, Hepatitis A Virus Cellular Receptor 2, Aged, Membrane Glycoproteins, Prostatic neoplasms - chemistry, Membrane Proteins, Prostatic Neoplasms, Membrane glycoproteins - analysis, Middle Aged, Prostate-Specific Antigen, Membrane proteins - analysis, ta3122, ADP-ribosyl Cyclase 1, 3. Good health, Prostate-specific antigen - immunology, CD8-positive T-lymphocytes - immunology, Hepatitis A virus cellular receptor 2 |
| Description: | The efficacy of immunotherapy in cancer patients is influenced by differences in their immune status. An evaluation of immunocompetence before therapy may help to predict therapeutic success and guide the selection of appropriate regimens. We assessed the preexisting cellular immunity against prostate-specific antigen (PSA) in untreated prostate cancer patients and healthy controls through measurement of the phenotype and function of CD8(+) T cells. Our data show that the majority of healthy men possess functional PSA-specific CD8(+) T cells in contrast to cancer patients, where |
| Document Type: | Article |
| Language: | English |
| ISSN: | 1432-0851 0340-7004 |
| DOI: | 10.1007/s00262-015-1752-y |
| DOI: | 10.1007/s002620151752y |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/26289091 http://juuli.fi/Record/0006766915 https://doi.org/10.1007/s002620151752y http://juuli.fi/Record/0250187415 https://www.ncbi.nlm.nih.gov/pubmed/26289091 https://pubmed.ncbi.nlm.nih.gov/26289091/ https://link.springer.com/article/10.1007/s00262-015-1752-y/fulltext.html https://link.springer.com/article/10.1007/s00262-015-1752-y http://europepmc.org/abstract/MED/26289091 |
| Rights: | Springer TDM |
| Accession Number: | edsair.doi.dedup.....7cbc6ae39d7c8f7e99fbee5dc3532dbf |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | The efficacy of immunotherapy in cancer patients is influenced by differences in their immune status. An evaluation of immunocompetence before therapy may help to predict therapeutic success and guide the selection of appropriate regimens. We assessed the preexisting cellular immunity against prostate-specific antigen (PSA) in untreated prostate cancer patients and healthy controls through measurement of the phenotype and function of CD8(+) T cells. Our data show that the majority of healthy men possess functional PSA-specific CD8(+) T cells in contrast to cancer patients, where |
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| ISSN: | 14320851 03407004 |
| DOI: | 10.1007/s00262-015-1752-y |