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Sirtuin1 expression and survival in endometrial and clear-cell uterine cancer

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Title: Sirtuin1 expression and survival in endometrial and clear-cell uterine cancer
Authors: Beyer, Susanne, Chen, Fangfang, Meister, Sarah, Czogalla, Bastian, Kolben, Theresa M., Hester, Anna, Burges, Alexander, Trillsch, Fabian, Schmöckel, Elisa, Mayr, Doris, Mayerhofer, Artur, Mahner, Sven, Jeschke, Udo, Kolben, Thomas
Source: Histochem Cell Biol
Publisher Information: Springer Science and Business Media LLC, 2020.
Publication Year: 2020
Subject Terms: 0301 basic medicine, Original Paper, 0303 health sciences, Female [MeSH], Endometrial Neoplasms/metabolism [MeSH], Aged [MeSH], Humans [MeSH], Endometrial cancer, Survival Analysis [MeSH], Sirtuin1, HDAC, Immunohistochemistry [MeSH], Endometrial Neoplasms/pathology [MeSH], Sirtuin 1/biosynthesis [MeSH], Survival, Adenocarcinoma, Clear Cell/pathology [MeSH], Uterine Neoplasms/pathology [MeSH], Adenocarcinoma, Clear Cell/metabolism [MeSH], Uterine Neoplasms/metabolism [MeSH], Immunohistochemistry, Survival Analysis, Endometrial Neoplasms, 3. Good health, 03 medical and health sciences, Sirtuin 1, Uterine Neoplasms, Humans, Female, Adenocarcinoma, Clear Cell, Aged
Description: Several risk factors like obesity and hyperlipidemia were described for endometrial cancer. Here, the nuclear NAD-dependent histone-deacetylase Sirtuin1 (SIRT1) seems to be important. SIRT1 is also involved in cell regulatory mechanisms and can serve as tumor promotor or suppressor. Its role in tumor biology is not clear yet. In this study, we evaluated and correlated the SIRT1 expression with patients’ tumor characteristics in endometrioid and clear-cell cancer of the uterus. 65 paraffin-embedded samples of patients with endometrial and clear-cell cancer of the uterus were immunohistochemically stained and SIRT1 expression was evaluated by immunoreactive score. The results were correlated to clinical and pathological tumor characteristics as well as to the expression of ARID1A and β-Catenin. The staining was significantly more intensive in uterine endometrioid carcinoma compared to uterine clear-cell carcinoma (p = 0.007). The expression of SIRT1 correlated significantly with the membranous expression of β-Catenin (p = 0.028) and ARID1A (p = 0.021). Patients with positive Sirtuin1 expression had a significantly better progression-free survival (p = 0.042), the overall survival showed a trend towards a better prognosis (p = 0.070). SIRT1 expression seems to be associated with improved progression-free survival in uterine cancer (endometrioid and clear-cell) and is correlated to the tumor suppressors β-Catenin and ARID1A. Further studies are necessary to elucidate the role of SIRT1 in uterine and ovarian cancer and its potential as a therapeutic target.
Document Type: Article
Other literature type
Language: English
ISSN: 1432-119X
0948-6143
DOI: 10.1007/s00418-020-01873-x
DOI: 10.1055/s-0040-1717187
Access URL: https://link.springer.com/content/pdf/10.1007/s00418-020-01873-x.pdf
https://epub.ub.uni-muenchen.de/73081/1/Beyer2020_Article_Sirtuin1ExpressionAndSurvivalI.pdf
https://pubmed.ncbi.nlm.nih.gov/32388637
https://www.ncbi.nlm.nih.gov/pubmed/32388637
https://link.springer.com/article/10.1007/s00418-020-01873-x
https://pubmed.ncbi.nlm.nih.gov/32388637/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429549
https://link.springer.com/content/pdf/10.1007/s00418-020-01873-x.pdf
https://epub.ub.uni-muenchen.de/73081/
http://www.thieme-connect.de/products/ejournals/html/10.1055/s-0040-1717187
https://repository.publisso.de/resource/frl:6467542
https://epub.ub.uni-muenchen.de/73081/
Rights: CC BY
Accession Number: edsair.doi.dedup.....7a4a172a48a0160c4c67d252cd402dfe
Database: OpenAIRE
Description
Abstract:Several risk factors like obesity and hyperlipidemia were described for endometrial cancer. Here, the nuclear NAD-dependent histone-deacetylase Sirtuin1 (SIRT1) seems to be important. SIRT1 is also involved in cell regulatory mechanisms and can serve as tumor promotor or suppressor. Its role in tumor biology is not clear yet. In this study, we evaluated and correlated the SIRT1 expression with patients’ tumor characteristics in endometrioid and clear-cell cancer of the uterus. 65 paraffin-embedded samples of patients with endometrial and clear-cell cancer of the uterus were immunohistochemically stained and SIRT1 expression was evaluated by immunoreactive score. The results were correlated to clinical and pathological tumor characteristics as well as to the expression of ARID1A and β-Catenin. The staining was significantly more intensive in uterine endometrioid carcinoma compared to uterine clear-cell carcinoma (p = 0.007). The expression of SIRT1 correlated significantly with the membranous expression of β-Catenin (p = 0.028) and ARID1A (p = 0.021). Patients with positive Sirtuin1 expression had a significantly better progression-free survival (p = 0.042), the overall survival showed a trend towards a better prognosis (p = 0.070). SIRT1 expression seems to be associated with improved progression-free survival in uterine cancer (endometrioid and clear-cell) and is correlated to the tumor suppressors β-Catenin and ARID1A. Further studies are necessary to elucidate the role of SIRT1 in uterine and ovarian cancer and its potential as a therapeutic target.
ISSN:1432119X
09486143
DOI:10.1007/s00418-020-01873-x