Clinical significance of primary tumor resection in colorectal cancer patients with synchronous unresectable metastasis: Palliative Surgery in Colorectal Cancer
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| Názov: | Clinical significance of primary tumor resection in colorectal cancer patients with synchronous unresectable metastasis: Palliative Surgery in Colorectal Cancer |
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| Autori: | Min Sung Kim, MinKyu Chung, Nam Kyu Kim, Se Jin Baek, Byung Soh Min, Chang Woo Kim, Min Soo Cho, Sang Joon Shin, Hyuk Hur, Seung Hyuk Baik, Joong Bae Ahn |
| Prispievatelia: | Min Sung Kim, MinKyu Chung, Joong Bae Ahn, Chang Woo Kim, Min Soo Cho, Sang Joon Shin, Se Jin Baek, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Nam Kyu Kim, Kim, Chang Woo, Min, Byung Soh, Baek, Se Jin, Baik, Seung Hyuk, Shin, Sang Joon, Ahn, Joong Bae, Jung, Min Kyu, Cho, Min Soo, Hur, Hyuk, Kim, Nam Kyu, Kim, Min Sung |
| Zdroj: | Journal of Surgical Oncology. 110:214-221 |
| Informácie o vydavateľovi: | Wiley, 2014. |
| Rok vydania: | 2014 |
| Predmety: | Male, Leucovorin, Kaplan-Meier Estimate, Deoxycytidine, 0302 clinical medicine, Organoplatinum Compounds/therapeutic use, Antineoplastic Combined Chemotherapy Protocols, Neoplasm Metastasis, Adjuvant, Colectomy, Leucovorin/therapeutic use, Colorectal Neoplasms/drug therapy, Middle Aged, Antineoplastic Agents/administration & dosage, 3. Good health, Survival Rate, Fluorouracil/analogs & derivatives, Treatment Outcome, Chemotherapy, Adjuvant, Female, Fluorouracil, Colorectal Neoplasms, Rectum/surgery, Camptothecin/analogs & derivatives, Adult, Deoxycytidine/analogs & derivatives, Antineoplastic Agents, Fluorouracil/therapeutic use, Drug Administration Schedule, 03 medical and health sciences, synchronous unresectable metastasis, Chemotherapy, Humans, Camptothecin/therapeutic use, Capecitabine, Retrospective Studies, Aged, Palliative Care/methods, Colorectal Neoplasms/surgery, Colorectal Neoplasms/pathology, Colorectal Neoplasms/mortality, primary tumor resection, Asymptomatic Diseases, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Camptothecin, colorectal neoplasm, Deoxycytidine/therapeutic use, Follow-Up Studies |
| Popis: | The aim of this study was to compare the outcomes in colorectal cancer (CRC) patients with synchronous unresectable metastases who received either primary tumor resection (PTR) or chemotherapy as the first treatment and to investigate the clinical course of asymptomatic patients who received chemotherapy as the first treatment.We retrospectively analyzed 324 CRC patients with synchronous unresectable metastases. Overall survival (OS) was analyzed for the two groups (upfront PTR group [n = 72] vs. upfront chemotherapy group [n = 252]). Surgical morbidity and mortality were recorded. In the asymptomatic patients who received upfront chemotherapy, the incidences of primary tumor-related complications were analyzed.In patients who underwent PTR as the first treatment, the median OS period was superior to those who received upfront chemotherapy (17.2 vs. 13.6 months, P = 0.002). In the PTR group, surgical morbidity and mortality were 11.6% and 1.9%, respectively. Of the 252 asymptomatic patients, the incidence of primary tumor-related complications was 35%. Emergent surgery was ultimately done in 14% of the 252 patients.CRC patients with synchronous unresectable metastases who underwent PTR followed by chemotherapy had significantly longer survival times compared to patients who received chemotherapy as the first treatment. |
| Druh dokumentu: | Article |
| Popis súboru: | 214~221 |
| Jazyk: | English |
| ISSN: | 0022-4790 |
| DOI: | 10.1002/jso.23607 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/24668581 https://yonsei.pure.elsevier.com/en/publications/clinical-significance-of-primary-tumor-resection-in-colorectal-ca https://europepmc.org/article/MED/24668581 https://koreauniv.pure.elsevier.com/en/publications/clinical-significance-of-primary-tumor-resection-in-colorectal-ca https://ir.ymlib.yonsei.ac.kr/handle/22282913/99671 https://onlinelibrary.wiley.com/doi/full/10.1002/jso.23607 https://www.ncbi.nlm.nih.gov/pubmed/24668581 |
| Rights: | Wiley TDM CC BY NC ND |
| Prístupové číslo: | edsair.doi.dedup.....7a3c1ef4811a387a4d5eef5f71fb7b0b |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | The aim of this study was to compare the outcomes in colorectal cancer (CRC) patients with synchronous unresectable metastases who received either primary tumor resection (PTR) or chemotherapy as the first treatment and to investigate the clinical course of asymptomatic patients who received chemotherapy as the first treatment.We retrospectively analyzed 324 CRC patients with synchronous unresectable metastases. Overall survival (OS) was analyzed for the two groups (upfront PTR group [n = 72] vs. upfront chemotherapy group [n = 252]). Surgical morbidity and mortality were recorded. In the asymptomatic patients who received upfront chemotherapy, the incidences of primary tumor-related complications were analyzed.In patients who underwent PTR as the first treatment, the median OS period was superior to those who received upfront chemotherapy (17.2 vs. 13.6 months, P = 0.002). In the PTR group, surgical morbidity and mortality were 11.6% and 1.9%, respectively. Of the 252 asymptomatic patients, the incidence of primary tumor-related complications was 35%. Emergent surgery was ultimately done in 14% of the 252 patients.CRC patients with synchronous unresectable metastases who underwent PTR followed by chemotherapy had significantly longer survival times compared to patients who received chemotherapy as the first treatment. |
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| ISSN: | 00224790 |
| DOI: | 10.1002/jso.23607 |