Use of Floseal Hemostatic Matrix for Control of Hemostasis During Laparoscopic Cholecystectomy for Acute Cholecystitis: A Multicenter Historical Control Group Comparison (The GLA Study Gelatin Matrix for Acute Cholecystitis)
Uloženo v:
| Název: | Use of Floseal Hemostatic Matrix for Control of Hemostasis During Laparoscopic Cholecystectomy for Acute Cholecystitis: A Multicenter Historical Control Group Comparison (The GLA Study Gelatin Matrix for Acute Cholecystitis) |
|---|---|
| Autoři: | Sartelli M1, Catena F, BIANCAFARINA, Alessia, Tranà C, Piccardo A, CECCARELLI, GRAZIANO, Tirone G, Agresta F, Di Giorgio A, Catani M, Tricarico F, Buonanno M, Piazza L. |
| Zdroj: | Journal of Laparoendoscopic & Advanced Surgical Techniques. 24:837-841 |
| Informace o vydavateli: | Mary Ann Liebert Inc, 2014. |
| Rok vydání: | 2014 |
| Témata: | Adult, Male, 2. Zero hunger, 0301 basic medicine, 0303 health sciences, Adult Aged Blood Loss, Surgical / prevention & control* Cholecystectomy, Laparoscopic / methods Cholecystitis, Acute / surgery* Cohort Studies Female Gelatin Sponge, Absorbable / pharmacology* Hemostatic Techniques* Hemostatics / pharmacology Humans Male Middle Aged Postoperative Hemorrhage / prevention & control* Prospective Studies Young Adult, Hemostatic Techniques, Cholecystitis, Acute, Blood Loss, Surgical, Middle Aged, Postoperative Hemorrhage, Gelatin Sponge, Absorbable, Hemostatics, 3. Good health, Cohort Studies, Young Adult, 03 medical and health sciences, Cholecystectomy, Laparoscopic, acute cholecystitis, Humans, Female, Prospective Studies, Aged |
| Popis: | In patients with acute cholecystitis undergoing laparoscopic cholecystectomy, bleeding is a common complication that can reduce procedural visibility and worsen outcome. Insufficient hemostasis can also lead to postoperative bleeding that can, in rare cases, be fatal. Topical hemostatic agents are used to ensure adequate hemostasis during laparoscopic cholecystectomy.This prospective, open-label, nonrandomized, historical control group study investigated the use of Floseal(®) (Baxter International, Inc., Deerfield, IL) hemostatic matrix as an adjunct to surgical techniques to achieve hemostasis of the resected areas in patients undergoing laparoscopic cholecystectomy for acute cholecystitis. The primary end point was the rate of complete hemostasis 10 minutes after laparoscopic application of Floseal to the gallbladder bed. Secondary end points included complete hemostasis rates at 2, 4, and 6 minutes, surgery time, laparoscopic procedure to open laparotomy conversion rate, postoperative bleeding rate, and mortality and safety outcomes over the entire follow-up period.From April to November 2011, 101 consecutive patients were enrolled (51 men; mean age, 61.5±6.2 years). The historical control group of 100 age- and gender-matched patients with acute cholecystitis had undergone laparoscopic cholecystectomy without hemostatic agent. In the Floseal group, bleeding ceased within 10 minutes after laparoscopic application of the hemostatic agent to the gallbladder bed in all patients. The conversion rate was significantly lower in the Floseal group than in the control group (4 versus 12 patients, P |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1557-9034 1092-6429 |
| DOI: | 10.1089/lap.2013.0495 |
| DOI: | 10.1089/lap.2013.0495. |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/25025393 https://www.ncbi.nlm.nih.gov/pubmed/25025393 http://www.liebertpub.com/doi/10.1089/lap.2013.0495 https://pubmed.ncbi.nlm.nih.gov/25025393/ https://core.ac.uk/display/54516841 https://www.liebertpub.com/doi/10.1089/lap.2013.0495 https://hdl.handle.net/11573/769608 https://doi.org/10.1089/lap.2013.0495. |
| Rights: | Mary Ann Liebert TDM |
| Přístupové číslo: | edsair.doi.dedup.....7a30600c646666dcb4d35971b70009e1 |
| Databáze: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | In patients with acute cholecystitis undergoing laparoscopic cholecystectomy, bleeding is a common complication that can reduce procedural visibility and worsen outcome. Insufficient hemostasis can also lead to postoperative bleeding that can, in rare cases, be fatal. Topical hemostatic agents are used to ensure adequate hemostasis during laparoscopic cholecystectomy.This prospective, open-label, nonrandomized, historical control group study investigated the use of Floseal(®) (Baxter International, Inc., Deerfield, IL) hemostatic matrix as an adjunct to surgical techniques to achieve hemostasis of the resected areas in patients undergoing laparoscopic cholecystectomy for acute cholecystitis. The primary end point was the rate of complete hemostasis 10 minutes after laparoscopic application of Floseal to the gallbladder bed. Secondary end points included complete hemostasis rates at 2, 4, and 6 minutes, surgery time, laparoscopic procedure to open laparotomy conversion rate, postoperative bleeding rate, and mortality and safety outcomes over the entire follow-up period.From April to November 2011, 101 consecutive patients were enrolled (51 men; mean age, 61.5±6.2 years). The historical control group of 100 age- and gender-matched patients with acute cholecystitis had undergone laparoscopic cholecystectomy without hemostatic agent. In the Floseal group, bleeding ceased within 10 minutes after laparoscopic application of the hemostatic agent to the gallbladder bed in all patients. The conversion rate was significantly lower in the Floseal group than in the control group (4 versus 12 patients, P |
|---|---|
| ISSN: | 15579034 10926429 |
| DOI: | 10.1089/lap.2013.0495 |