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Accelerated loss of lean body mass in head and neck cancer patients during cisplatin-based chemoradiation

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Bibliographic Details
Title: Accelerated loss of lean body mass in head and neck cancer patients during cisplatin-based chemoradiation
Authors: Simon Lønbro, Søren Gam, Anne Pernille Hermann, Christian Rønn Hansen, Jørgen Johansen
Source: Lønbro, S, Gam, S, Hermann, A P, Hansen, C R & Johansen, J 2023, 'Accelerated loss of lean body mass in head and neck cancer patients during cisplatin-based chemoradiation', Acta Oncologica, vol. 62, no. 11, pp. 1403-1411. https://doi.org/10.1080/0284186X.2023.2245558
Publisher Information: MJS Publishing, Medical Journals Sweden AB, 2023.
Publication Year: 2023
Subject Terms: body composition, Body Composition/physiology, Squamous Cell Carcinoma of Head and Neck, Body Weight, lean body mass, Chemoradiotherapy, Chemoradiotherapy/adverse effects, concurrent chemoradiation, 3. Good health, radiation, Head and Neck Neoplasms, functional performance, muscle strength, Body Composition, Humans, Cisplatin, Head and neck cancer
Description: This study investigated changes in body weight, lean body mass (LBM), fat mass (FM), muscle strength and functional performance during radiation treatment in head and neck cancer (HNSCC) patients. Secondly, it investigated the impact of cisplatin-based chemoradiation (CCRT) on LBM loss compared with radiation alone.48 patients (all tumor sites) received either 6 weeks of radiation alone (n = 16) with 66-68 Gy in 33-34 Fx, 5-6 Fx/week or CCRT, adding weekly cisplatin or carboplatin (n = 32). LBM and FM was evaluated using Dual-energy X-ray Absorptiometry bi-weekly from pre- to two weeks post-treatment. Maximal muscle strength (knee extension, leg - and chest press) and functional performance (stair climb, chair rise, and arm curl) were assessed pre- and post-treatment.Body weight and LBM had declined significantly already week 2 into treatment and declined significantly further through week 4 and 6 before leveling off after week 6. Bi-weekly, from treatment start to week 2, 2-4, and 4-6, LBM declined 1.2 ± 0.4 kg (p = .002; 95% CI: 0.4;2.0), 2.0 ± 0.4 kg (p
Document Type: Article
Language: English
ISSN: 1651-226X
0284-186X
DOI: 10.1080/0284186x.2023.2245558
Access URL: https://pubmed.ncbi.nlm.nih.gov/37589161
https://portal.findresearcher.sdu.dk/da/publications/654df4d9-8cb5-4849-b2d1-c28e88c15996
https://doi.org/10.1080/0284186X.2023.2245558
Accession Number: edsair.doi.dedup.....7945e301884047c753d6d07dafecde26
Database: OpenAIRE
Description
Abstract:This study investigated changes in body weight, lean body mass (LBM), fat mass (FM), muscle strength and functional performance during radiation treatment in head and neck cancer (HNSCC) patients. Secondly, it investigated the impact of cisplatin-based chemoradiation (CCRT) on LBM loss compared with radiation alone.48 patients (all tumor sites) received either 6 weeks of radiation alone (n = 16) with 66-68 Gy in 33-34 Fx, 5-6 Fx/week or CCRT, adding weekly cisplatin or carboplatin (n = 32). LBM and FM was evaluated using Dual-energy X-ray Absorptiometry bi-weekly from pre- to two weeks post-treatment. Maximal muscle strength (knee extension, leg - and chest press) and functional performance (stair climb, chair rise, and arm curl) were assessed pre- and post-treatment.Body weight and LBM had declined significantly already week 2 into treatment and declined significantly further through week 4 and 6 before leveling off after week 6. Bi-weekly, from treatment start to week 2, 2-4, and 4-6, LBM declined 1.2 ± 0.4 kg (p = .002; 95% CI: 0.4;2.0), 2.0 ± 0.4 kg (p
ISSN:1651226X
0284186X
DOI:10.1080/0284186x.2023.2245558