Zobrazit v EDS

Trabecular Bone Score as a Marker of Skeletal Fragility Across the Spectrum of Chronic Kidney Disease: A Systematic Review and Meta-analysis

Uloženo v:
Podrobná bibliografie
Název: Trabecular Bone Score as a Marker of Skeletal Fragility Across the Spectrum of Chronic Kidney Disease: A Systematic Review and Meta-analysis
Autoři: Bioletto F., Barale M., Maiorino F., Pusterla A., Fraire F., Arvat E., Ghigo E., Procopio M.
Zdroj: The Journal of Clinical Endocrinology & Metabolism. 109:e1534-e1543
Informace o vydavateli: The Endocrine Society, 2023.
Rok vydání: 2023
Témata: Fractures, Bone, Bone Density, Renal Dialysis, CKD-MBD, bone fragility, chronic kidney disease, dialysis, fractures, kidney transplant, renal osteodystrophy, trabecular bone score, Cancellous Bone, Humans, Renal Insufficiency, Chronic, Biomarkers, 3. Good health
Popis: Context The impairment of bone microarchitecture is a key determinant of skeletal fragility in patients with chronic kidney disease (CKD). The trabecular bone score (TBS) has been developed as a reliable noninvasive index of bone quality. However, its utility in this setting is still debated. Objective The aim of this systematic review and meta-analysis was to summarize the available evidence about TBS as a marker of skeletal fragility across the spectrum of CKD. Methods PubMed/Medline, EMBASE, and Cochrane Library databases were systematically searched until July 2023 for studies reporting data about TBS in patients with CKD. Effect sizes were pooled through a random-effect model. Results Compared to controls, lower TBS values were observed in CKD patients not on dialysis (−0.057, 95%CI:[−0.090, −0.024], P < .01), in dialysis patients (−0.106, 95%CI:[−0.141, −0.070], P < .01), and in kidney transplant recipients (KTRs) (−0.058, 95%CI:[−0.103, −0.012], P = .01). With respect to fracture risk, TBS was able to predict incident fractures in nondialysis patients at unadjusted analyses (hazard ratio [HR] per SD decrease: 1.45, 95%CI:[1.05, 2.00], P = .02), though only a nonsignificant trend was maintained when fully adjusting the model for FRAX® (HR = 1.26, 95%CI:[0.88, 1.80], P = .21). Dialysis patients with prevalent fractures had lower TBS values compared to unfractured ones (−0.070, 95% CI:[−0.111, −0.028], P < .01). Some studies supported a correlation between TBS and fracture risk in KTRs, but results could not be pooled due to the lack of sufficient data. Conclusion CKD patients are characterized by an impairment of bone microarchitecture, as demonstrated by lower TBS values, across the whole spectrum of kidney disease. TBS can also be helpful in the discrimination of fracture risk, with lower values being correlated with a higher risk of prevalent and incident fractures.
Druh dokumentu: Article
Jazyk: English
ISSN: 1945-7197
0021-972X
DOI: 10.1210/clinem/dgad724
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38079472
Rights: OUP Standard Publication Reuse
Přístupové číslo: edsair.doi.dedup.....787885422ded743ed1a138c5921e4bb0
Databáze: OpenAIRE
Popis
Abstrakt:Context The impairment of bone microarchitecture is a key determinant of skeletal fragility in patients with chronic kidney disease (CKD). The trabecular bone score (TBS) has been developed as a reliable noninvasive index of bone quality. However, its utility in this setting is still debated. Objective The aim of this systematic review and meta-analysis was to summarize the available evidence about TBS as a marker of skeletal fragility across the spectrum of CKD. Methods PubMed/Medline, EMBASE, and Cochrane Library databases were systematically searched until July 2023 for studies reporting data about TBS in patients with CKD. Effect sizes were pooled through a random-effect model. Results Compared to controls, lower TBS values were observed in CKD patients not on dialysis (−0.057, 95%CI:[−0.090, −0.024], P < .01), in dialysis patients (−0.106, 95%CI:[−0.141, −0.070], P < .01), and in kidney transplant recipients (KTRs) (−0.058, 95%CI:[−0.103, −0.012], P = .01). With respect to fracture risk, TBS was able to predict incident fractures in nondialysis patients at unadjusted analyses (hazard ratio [HR] per SD decrease: 1.45, 95%CI:[1.05, 2.00], P = .02), though only a nonsignificant trend was maintained when fully adjusting the model for FRAX® (HR = 1.26, 95%CI:[0.88, 1.80], P = .21). Dialysis patients with prevalent fractures had lower TBS values compared to unfractured ones (−0.070, 95% CI:[−0.111, −0.028], P < .01). Some studies supported a correlation between TBS and fracture risk in KTRs, but results could not be pooled due to the lack of sufficient data. Conclusion CKD patients are characterized by an impairment of bone microarchitecture, as demonstrated by lower TBS values, across the whole spectrum of kidney disease. TBS can also be helpful in the discrimination of fracture risk, with lower values being correlated with a higher risk of prevalent and incident fractures.
ISSN:19457197
0021972X
DOI:10.1210/clinem/dgad724