ATG9A controls all stages of autophagosome biogenesis
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| Titel: | ATG9A controls all stages of autophagosome biogenesis |
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| Autoren: | Ruheena Javed, Muriel Mari, Einar Trosdal, Thabata Lopes Alberto Duque, Masroor Paddar, Lee Allers, Prithvi Akepati, Michal H. Mudd, Fulvio Reggiori, Vojo Deretic |
| Quelle: | Javed, R, Mari, M, Trosdal, E, Lopes Alberto Duque, T, Paddar, M, Allers, L, Akepati, P, Mudd, M H, Reggiori, F & Deretic, V 2025, 'ATG9A controls all stages of autophagosome biogenesis', Autophagy, vol. 21, no. 8, pp. 1859-1861. https://doi.org/10.1080/15548627.2025.2494802 |
| Verlagsinformationen: | Informa UK Limited, 2025. |
| Publikationsjahr: | 2025 |
| Schlagwörter: | Mice, Endosomal Sorting Complexes Required for Transport/metabolism, Autophagy-Related Proteins/metabolism, Vesicular Transport Proteins/metabolism, Humans, Animals, Autophagosomes/metabolism, Membrane Proteins/metabolism, Autophagy/physiology, HeLa Cells |
| Beschreibung: | Canonical autophagy is an intracellular pathway that degrades and recycles cellular components. A key step of this pathway is the formation of double-membraned organelles, known as autophagosomes, an emblematic feature of macroautophagy. For convenience, the formation of autophagosomes can be categorized into sequential steps, initiation (X), expansion (Y) and closure (Z). ATG9A is an integral membrane protein known for its role in the X and Y steps. whereby it organizes phagophore membrane assembly and its growth. Here, we report a previously unappreciated function of mammalian ATG9A in directing the last step Z. In particular, ATG9A partners with the key ESCRT-III component CHMP2A through IQGAP1 to facilitate autophagosome closure. Thus, ATG9A orchestrates all stages of autophagosome membrane biogenesis, from phagophore initiation to its closure. This makes ATG9A a unique ATG factor that works as a central hub in autophagosome biogenesis. |
| Publikationsart: | Article |
| Sprache: | English |
| ISSN: | 1554-8635 1554-8627 |
| DOI: | 10.1080/15548627.2025.2494802 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/40241347 |
| Dokumentencode: | edsair.doi.dedup.....77f8f44a1141fbfb668b46539ca5fc54 |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Canonical autophagy is an intracellular pathway that degrades and recycles cellular components. A key step of this pathway is the formation of double-membraned organelles, known as autophagosomes, an emblematic feature of macroautophagy. For convenience, the formation of autophagosomes can be categorized into sequential steps, initiation (X), expansion (Y) and closure (Z). ATG9A is an integral membrane protein known for its role in the X and Y steps. whereby it organizes phagophore membrane assembly and its growth. Here, we report a previously unappreciated function of mammalian ATG9A in directing the last step Z. In particular, ATG9A partners with the key ESCRT-III component CHMP2A through IQGAP1 to facilitate autophagosome closure. Thus, ATG9A orchestrates all stages of autophagosome membrane biogenesis, from phagophore initiation to its closure. This makes ATG9A a unique ATG factor that works as a central hub in autophagosome biogenesis. |
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| ISSN: | 15548635 15548627 |
| DOI: | 10.1080/15548627.2025.2494802 |