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Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry

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Title: Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry
Authors: Cobo Ibáñez, Tatiana, Castellví, Ivan, Pros, Ana, Domínguez Álvaro, Marta, Nuño Nuño, Laura, Martínez Barrio, Julia, Jovaní, Vega, Romero Bueno, Fredeswinda, Ruiz Lucea, Esther, Tomero, Eva, Trallero Araguás, Ernesto, Narváez, Javier, Camins Fàbregas, Jordi, Ruiz Román, Alberto, Loarce Martos, Jesús, Holgado, Susana, Flores Rodríguez, V. Miguel, Sivera, Francisca, Merino Argumanez, Carolina, Juan Mas, Antonio, Altabás González, Irene, Martín López, María, Belzunegui Otano, Joaquín María, Carrasco Cubero, Carmen, Freire González, Mercedes, Rúa Figueroa, Iñigo, Lozano Rivas, Nuria, Suarez Cuba, Julio David, Martínez, Olga, Ortega Castro, Rafaela, Alcocer, Patricia, Gómez Gómez, Alejandro, Sánchez Pernaute, Olga, Tandaipan, José Luis, Carrión Barberà, Irene, Plasencia Rodríguez, Chamaida, Ibarguengoitia Barrena, Oihane, Vidal Montal, Paola, Ortiz Santamaria, Vera, Garrido Puñal, Noemi, Riveros, Anne, Delgado Frías, Esmeralda, López Gómez, Juan Miguel, Barbadillo, Carmen, Pego Reigosa, José María, Joven, Beatriz, Valero Jaimes, Jesús Alejandro, Naveda, Elena, Turrión Nieves, Ana Isabel, Seoane Mato, Daniel, Prado Galbarro, Francisco Javier, Puche Larrubia, María Ángeles
Contributors: [Cobo-Ibáñez T] Rheumatology Department, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain. Department of Medicine, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Madrid, Spain. [Castellví I] Servei de Reumatologia, Hospital Universitari de la Santa Creu I Sant Pau, Barcelona, Spain. [Pros A] Rheumatology Department, Hospital del Mar, Barcelona, Spain. [Domínguez-Álvaro M] Unidad de Investigación, Sociedad Española de Reumatología, Madrid, Spain. [Nuño-Nuño L] Rheumatology Department, Hospital Universitario la Paz, Madrid, Spain. [Martínez-Barrio J] Rheumatology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Ortiz-Santamaria V] Rheumatology Department, Hospital General de Granollers, Granollers, Spain, Hospital General de Granollers
Source: Arthritis Res Ther
Scientia
Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Dipòsit Digital de la UB
ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)
ARTHRITIS RESEARCH & THERAPY
r-FISABIO. Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Docusalut
Conselleria de Salut i Consum del Govern de les Illes Balears
Arthritis Research & Therapy, Vol 27, Iss 1, Pp 1-12 (2025)
Publisher Information: Springer Science and Business Media LLC, 2025.
Publication Year: 2025
Subject Terms: Male, Time Factors, España, Diseases of the musculoskeletal system, Autoanticossos, Severity of Illness Index, CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies, Tratamiento médico, DISEASES::Musculoskeletal Diseases::Muscular Diseases::Myositis, Registries, Masculino, Persona de Mediana Edad, COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::autoanticuerpos, Adulto, Femenino, Autoanticuerpos, Middle Aged, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico, Humanos, Damage, ENFERMEDADES::enfermedades musculoesqueléticas::enfermedades musculares::miositis, Danys, Female, Enfermedad, Adult, Anciano, Músculs - Malalties, Estudios Transversales, Índice de Severidad de la Enfermedad, Sistema de Registros, Registros de investigación, Antisynthetase, Humans, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis, Aged, Autoantibodies, Myositis, Research, Registres, Activity, Cross-Sectional Studies, RC925-935, Spain, Quality of Life, Miositis, Miopaties inflamatòries idiopàtiques, Calidad de Vida, Idiopathic inflammatory myopathies, Factores de Tiempo
Description: OBJECTIVE: To evaluate the main outcomes of disease activity and their association with other measures of activity, damage, and quality of life in patients with idiopathic inflammatory myopathy (IIM) according to time since diagnosis and positivity to antisynthetase autoantibodies (ASAs). METHODS: Cross-sectional multicenter study within the Spanish Myo-Spain registry. Cases were classified as incident (≤ 12 months since diagnosis) and prevalent. The main outcomes of disease activity were the Myositis Disease Activity Assessment visual analogue scale (MYOACT), the Manual Muscle Test 8 (MMT-8), physician global activity (PhGA), and extramuscular activity. Other measures of activity, damage, and quality of life included patient global disease activity, MYOACT muscular, creatine phosphokinase, Health Assessment Questionnaire, physician and patient global damage, global damage of the Myositis Damage Index, and the 12-item Short-Form Health Survey (SF-12). We analyzed associations using a multivariate generalized linear model and a simple linear regression model. RESULTS: A total of 554 patients with different diagnostic subgroups of IIM were included (136 incident and 418 prevalent cases), with 215 ASA-positive patients (58 incident and 157 prevalent cases). All measures of disease activity were higher in the incident cases (p
Document Type: Article
Other literature type
File Description: application/pdf
Language: English
ISSN: 1478-6362
DOI: 10.1186/s13075-024-03471-x
Access URL: http://hdl.handle.net/11351/13083
https://hdl.handle.net/2445/218909
http://hdl.handle.net/11268/13656
https://fisabio.portalinvestigacion.com/publicaciones/18328
https://hdl.handle.net/20.500.13003/21589
https://doaj.org/article/aa2dd0dafee54b2d8f2a02ee914fae89
Rights: CC BY NC ND
Accession Number: edsair.doi.dedup.....77557732cbecc3b4769254c5c3201f48
Database: OpenAIRE
Description
Abstract:OBJECTIVE: To evaluate the main outcomes of disease activity and their association with other measures of activity, damage, and quality of life in patients with idiopathic inflammatory myopathy (IIM) according to time since diagnosis and positivity to antisynthetase autoantibodies (ASAs). METHODS: Cross-sectional multicenter study within the Spanish Myo-Spain registry. Cases were classified as incident (≤ 12 months since diagnosis) and prevalent. The main outcomes of disease activity were the Myositis Disease Activity Assessment visual analogue scale (MYOACT), the Manual Muscle Test 8 (MMT-8), physician global activity (PhGA), and extramuscular activity. Other measures of activity, damage, and quality of life included patient global disease activity, MYOACT muscular, creatine phosphokinase, Health Assessment Questionnaire, physician and patient global damage, global damage of the Myositis Damage Index, and the 12-item Short-Form Health Survey (SF-12). We analyzed associations using a multivariate generalized linear model and a simple linear regression model. RESULTS: A total of 554 patients with different diagnostic subgroups of IIM were included (136 incident and 418 prevalent cases), with 215 ASA-positive patients (58 incident and 157 prevalent cases). All measures of disease activity were higher in the incident cases (p
ISSN:14786362
DOI:10.1186/s13075-024-03471-x