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Comparison of First- and Second-Generation Drug-Eluting Stents in Patients with Acute Myocardial Infarction and Prediabetes Based on the Hemoglobin A1c Level

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Název: Comparison of First- and Second-Generation Drug-Eluting Stents in Patients with Acute Myocardial Infarction and Prediabetes Based on the Hemoglobin A1c Level
Autoři: Yong Hoon Kim, Ae-Young Her, Myung Ho Jeong, Byeong-Keuk Kim, Sung-Jin Hong, Seunghwan Kim, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
Přispěvatelé: Yong Hoon Kim, Ae-Young Her, Myung Ho Jeong, Byeong-Keuk Kim, Sung-Jin Hong, Seunghwan Kim, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Ko, Young Guk
Zdroj: J Interv Cardiol
Journal of Interventional Cardiology, Vol 2020 (2020)
Informace o vydavateli: Wiley, 2020.
Rok vydání: 2020
Témata: Myocardial Infarction / epidemiology, Male, Comparative Effectiveness Research, Myocardial Infarction / diagnosis, Myocardial Infarction, Percutaneous Coronary Intervention / methods, Prediabetic State, 03 medical and health sciences, Percutaneous Coronary Intervention, 0302 clinical medicine, Diseases of the circulatory (Cardiovascular) system, Humans, Glycated Hemoglobin A / analysis, Myocardial Infarction / surgery, Prediabetic State* / epidemiology, Glycated Hemoglobin, Incidence, Patient Selection, 4. Education, Drug-Eluting Stents* / classification, Drug-Eluting Stents, Middle Aged, 3. Good health, Treatment Outcome, Prediabetic State* / blood, RC666-701, Percutaneous Coronary Intervention / instrumentation, Percutaneous Coronary Intervention / adverse effects, Drug-Eluting Stents* / adverse effects, Female, Prediabetic State* / diagnosis, Research Article
Popis: Objective. To compare major clinical outcomes after successful percutaneous coronary intervention (PCI) with first-generation (1G) drug-eluting stents (DES) and second-generation (2G) DES in patients with acute myocardial infarction (AMI) and prediabetes. Background. Patients with prediabetes are associated with an increased incidence of coronary artery disease. The relative superiority of 1G- and 2G-DES in these patients is not well established. Methods. A total of 4997 patients with AMI and prediabetes were divided into two groups: the 1D-DES group (n = 726) and the 2G-DES group (n = 4271). The primary outcomes were the patient-oriented composite outcomes (POCOs) defined as all-cause death, recurrent myocardial infarction (Re-MI), and any disease revascularization at 2-year follow-up. The secondary outcome was probable or definite stent thrombosis (ST). Results. After propensity score-matching (PSM) analysis, two PSM groups (698 pairs, n = 1396, C-statistics = 0.725) were generated. The cumulative incidence rates of POCOs (hazard ratio (HR): 1.467; 95% confidence interval (CI): 1.068–2.015; p=0.018), any disease revascularization (HR: 2.259; 95% CI: 1.397–3.654; p=0.001), and ST (HR: 4.361; 95% CI: 1.243–15.30; p=0.021) in the 1G-DES group were significantly higher than those in the 2G-DES group. However, the cumulative incidence rates of all-cause death, cardiac death, and Re-MI were similar between the two groups. Conclusions. In patients with AMI and prediabetes, 2G-DES implantation was more efficacious than 1G-DES implantation over a 2-year follow-up period. However, further studies are needed to confirm these results.
Druh dokumentu: Article
Other literature type
Popis souboru: text/xhtml; application/pdf
Jazyk: English
ISSN: 1540-8183
0896-4327
DOI: 10.1155/2020/1710439
Přístupová URL adresa: https://downloads.hindawi.com/journals/jitc/2020/1710439.pdf
https://pubmed.ncbi.nlm.nih.gov/32733169
https://doaj.org/article/788474695dbc4e968fc4911e468ae8e5
https://downloads.hindawi.com/journals/jitc/2020/1710439.pdf
https://europepmc.org/article/MED/32733169
https://pubmed.ncbi.nlm.nih.gov/32733169/
https://yonsei.pure.elsevier.com/en/publications/comparison-of-first-a-nd-second-generation-drug-eluting-stents-in
https://yonsei.pure.elsevier.com/en/publications/comparison-of-first-and-second-generation-drug-eluting-stents-in-
https://www.hindawi.com/journals/jitc/2020/1710439/
Rights: CC BY
CC BY NC ND
Přístupové číslo: edsair.doi.dedup.....769e709a67446167b0cf87b0af831c3c
Databáze: OpenAIRE
Popis
Abstrakt:Objective. To compare major clinical outcomes after successful percutaneous coronary intervention (PCI) with first-generation (1G) drug-eluting stents (DES) and second-generation (2G) DES in patients with acute myocardial infarction (AMI) and prediabetes. Background. Patients with prediabetes are associated with an increased incidence of coronary artery disease. The relative superiority of 1G- and 2G-DES in these patients is not well established. Methods. A total of 4997 patients with AMI and prediabetes were divided into two groups: the 1D-DES group (n = 726) and the 2G-DES group (n = 4271). The primary outcomes were the patient-oriented composite outcomes (POCOs) defined as all-cause death, recurrent myocardial infarction (Re-MI), and any disease revascularization at 2-year follow-up. The secondary outcome was probable or definite stent thrombosis (ST). Results. After propensity score-matching (PSM) analysis, two PSM groups (698 pairs, n = 1396, C-statistics = 0.725) were generated. The cumulative incidence rates of POCOs (hazard ratio (HR): 1.467; 95% confidence interval (CI): 1.068–2.015; p=0.018), any disease revascularization (HR: 2.259; 95% CI: 1.397–3.654; p=0.001), and ST (HR: 4.361; 95% CI: 1.243–15.30; p=0.021) in the 1G-DES group were significantly higher than those in the 2G-DES group. However, the cumulative incidence rates of all-cause death, cardiac death, and Re-MI were similar between the two groups. Conclusions. In patients with AMI and prediabetes, 2G-DES implantation was more efficacious than 1G-DES implantation over a 2-year follow-up period. However, further studies are needed to confirm these results.
ISSN:15408183
08964327
DOI:10.1155/2020/1710439