Measurement of Multiple Solid Portions in Part-Solid Nodules for T Categorization: Evaluation of Prognostic Implication
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| Název: | Measurement of Multiple Solid Portions in Part-Solid Nodules for T Categorization: Evaluation of Prognostic Implication |
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| Autoři: | Young-Joo Suh, Jin Mo Goo, Eui Jin Hwang, Young Tae Kim, Chang Min Park, Hyungjin Kim |
| Přispěvatelé: | Hyungjin Kim, Jin Mo Goo, Young Joo Suh, Eui Jin Hwang, Chang Min Park, Young Tae Kim, Suh, Young Joo |
| Zdroj: | Journal of Thoracic Oncology. 13:1864-1872 |
| Informace o vydavateli: | Elsevier BV, 2018. |
| Rok vydání: | 2018 |
| Témata: | Male, Lung Neoplasms, Adenocarcinoma of Lung/surgery, Local/diagnostic imaging, Adenocarcinoma of Lung, Lung Neoplasms/diagnostic imaging, Lung Neoplasms/surgery, Adenocarcinoma, Multidetector computed tomography, 03 medical and health sciences, 0302 clinical medicine, Non-Small-Cell Lung/diagnostic imaging, Carcinoma, Non-Small-Cell Lung, Humans, Solitary Pulmonary Nodule/pathology, Lung Neoplasms/pathology, Adenocarcinoma of Lung/diagnostic imaging, Tomography, Aged, Neoplasm Staging, Retrospective Studies, Solitary Pulmonary Nodule/surgery, Carcinoma, Solitary Pulmonary Nodule, Non-Small-Cell Lung/surgery, Middle Aged, Non-Small-Cell Lung/pathology, X-Ray Computed/methods, Survival Rate, Solitary Pulmonary Nodule/diagnostic imaging, Neoplasm Recurrence, Solid portion, Local/pathology, Local/surgery, Part-solid nodule, Female, Neoplasm Recurrence, Local, Tomography, X-Ray Computed, Adenocarcinoma of Lung/pathology, Follow-Up Studies |
| Popis: | Our study aimed to analyze the prognostic implication of the multiplicity of solid portions in part-solid nodules (PSNs) on computed tomography scans and compare the prognostic performance of various measures of solid portions, including the single largest solid portion, solid proportion, and summated multiple solid portion measurements.The cases of a total of 345 patients with surgically resected stage IA adenocarcinomas manifesting as PSNs were retrospectively reviewed. The multiplicity of the solid portion in PSNs was determined and the diameter of each solid portion was measured. The prognostic implication of the multiplicity of the solid portion and other clinical variables in relation to disease-free survival (DFS) was analyzed by using Cox regression. In addition, risk stratification based on the single largest solid portion, sum of the solid portions, single solid proportion, and sum of the solid proportions was conducted. Next, concordance indices (C-indices) for DFS were obtained for each measure and compared. Intrareader and interreader measurement variability was assessed.Multiplicity of the solid portion did not have a significant effect on DFS; clinical T category was the only independent risk factor for tumor recurrence (p < 0.05). The C-index of the single solid portion (conventional clinical T category) was 0.817 (95% confidence interval: 0.691-0.942). There were no significant differences (p > 0.05) between the C-indices of the single solid portion and other solid portion measures. Interreader measurement variability was substantial.The current clinical T categorization of PSNs based on the single solid portion measurement is appropriate. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1556-0864 |
| DOI: | 10.1016/j.jtho.2018.09.023 |
| Přístupová URL adresa: | http://www.jto.org/article/S1556086418331757/pdf https://pubmed.ncbi.nlm.nih.gov/30292849 https://www.jto.org/article/S1556086418331757/pdf https://pubmed.ncbi.nlm.nih.gov/30292849/ https://snucm.elsevierpure.com/en/publications/measurement-of-multiple-solid-portions-in-part-solid-nodules-for- https://ir.ymlib.yonsei.ac.kr/handle/22282913/171223 https://europepmc.org/abstract/MED/30292849 https://www.sciencedirect.com/science/article/pii/S1556086418331757 |
| Rights: | Elsevier Non-Commercial CC BY NC ND |
| Přístupové číslo: | edsair.doi.dedup.....75ad5c34af98282d6f558feeb011b385 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Our study aimed to analyze the prognostic implication of the multiplicity of solid portions in part-solid nodules (PSNs) on computed tomography scans and compare the prognostic performance of various measures of solid portions, including the single largest solid portion, solid proportion, and summated multiple solid portion measurements.The cases of a total of 345 patients with surgically resected stage IA adenocarcinomas manifesting as PSNs were retrospectively reviewed. The multiplicity of the solid portion in PSNs was determined and the diameter of each solid portion was measured. The prognostic implication of the multiplicity of the solid portion and other clinical variables in relation to disease-free survival (DFS) was analyzed by using Cox regression. In addition, risk stratification based on the single largest solid portion, sum of the solid portions, single solid proportion, and sum of the solid proportions was conducted. Next, concordance indices (C-indices) for DFS were obtained for each measure and compared. Intrareader and interreader measurement variability was assessed.Multiplicity of the solid portion did not have a significant effect on DFS; clinical T category was the only independent risk factor for tumor recurrence (p < 0.05). The C-index of the single solid portion (conventional clinical T category) was 0.817 (95% confidence interval: 0.691-0.942). There were no significant differences (p > 0.05) between the C-indices of the single solid portion and other solid portion measures. Interreader measurement variability was substantial.The current clinical T categorization of PSNs based on the single solid portion measurement is appropriate. |
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| ISSN: | 15560864 |
| DOI: | 10.1016/j.jtho.2018.09.023 |