Classical determinants of coronary artery disease as predictors of complexity of coronary lesions, assessed with the SYNTAX score
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| Název: | Classical determinants of coronary artery disease as predictors of complexity of coronary lesions, assessed with the SYNTAX score |
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| Autoři: | Montero Cabezas, J.M., Karalis, I., Wolterbeek, R., Kraaijeveld, A.O., Hoefer, I.E., Pasterkamp, G., Pijls, N.H., Doevendans, P.A., Walterberger, J., Kuiper, J., Zonneveld, A.J. van, Jukema, J.W. |
| Přispěvatelé: | Cardiovasculaire Immunologie, Team Medisch, CDL Staf Research, Circulatory Health, CDL Arcadia, Experimentele Afd. Cardiologie 1, Onderzoek Vrouw Hart & Vaatziekten, Regenerative Medicine and Stem Cells, MS Oogheelkunde, Other research (not in main researchprogram) |
| Zdroj: | Neth Heart J |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2017. |
| Rok vydání: | 2017 |
| Témata: | RISK, Original Article - E‑Learning, Coronary angiography, PATHOPHYSIOLOGY, PROGRESSION, ASSOCIATION, SDG 3 – Goede gezondheid en welzijn, Coronary artery disease, 3. Good health, 03 medical and health sciences, SEVERITY, 0302 clinical medicine, MYOCARDIAL-INFARCTION, ATHEROSCLEROSIS, Risk factors, SDG 3 - Good Health and Well-being, CARDIOVASCULAR-DISEASE, Journal Article, TRIAL, Cardiology and Cardiovascular Medicine, INTERVENTION, Risk assessment |
| Popis: | We need new biomarkers that can predict cardiovascular disease to improve both diagnosis and therapeutic strategies. The CIRCULATING CELLS study was designed to study the role of several cellular mediators of atherosclerosis as biomarkers of coronary artery disease (CAD). An objective and reproducible method for the quantification of CAD extension is required to establish relationships with these potential biomarkers. We sought to analyse the correlation of the SYNTAX score with known CAD risk factors to test it as a valid marker of CAD extension.A subgroup of 279 patients (67.4% males) were included in our analysis. Main exclusion criteria were a history of previous percutaneous coronary intervention or surgical revascularisation that prevent an accurate assessment of the SS. Diabetes mellitus, smoking, renal insufficiency, body mass index and a history of CAD and myocardial infarction were all positively and strongly associated with a higher SYNTAX score after adjustment for the non-modifiable biological factors (age and sex). In the multivariate model, age and male sex, along with smoking and renal insufficiency, remain statistical significantly associated with the SYNTAX score.In a selected cohort of revascularisation-naive patients with CAD undergoing coronary angiography, non-modifiable cardiovascular risk factors such as advanced age, male sex, as well as smoking and renal failure were independently associated with CAD complexity assessed by the SYNTAX score. The SYNTAX score may be a valid marker of CAD extension to establish relationships with potential novel biomarkers of coronary atherosclerosis. |
| Druh dokumentu: | Article Other literature type |
| Popis souboru: | image/pdf; application/pdf |
| Jazyk: | English |
| ISSN: | 1876-6250 1568-5888 |
| DOI: | 10.1007/s12471-017-1005-0 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/28593492 https://research.tue.nl/nl/publications/classical-determinants-of-coronary-artery-disease-as-predictors-o https://cris.maastrichtuniversity.nl/en/publications/classical-determinants-of-coronary-artery-disease-as-predictors-o https://core.ac.uk/display/151302206 https://link.springer.com/content/pdf/10.1007%2Fs12471-017-1005-0.pdf https://dspace.library.uu.nl/handle/1874/356378 https://www.narcis.nl/publication/RecordID/oai%3Ascholarlypublications.universiteitleiden.nl%3Aitem_2945549 https://dspace.library.uu.nl/handle/1874/356378 https://hdl.handle.net/1887/94742 https://hdl.handle.net/1887/58941 |
| Rights: | CC BY |
| Přístupové číslo: | edsair.doi.dedup.....74f117119f9b91e532decdce3a0a7f7d |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | We need new biomarkers that can predict cardiovascular disease to improve both diagnosis and therapeutic strategies. The CIRCULATING CELLS study was designed to study the role of several cellular mediators of atherosclerosis as biomarkers of coronary artery disease (CAD). An objective and reproducible method for the quantification of CAD extension is required to establish relationships with these potential biomarkers. We sought to analyse the correlation of the SYNTAX score with known CAD risk factors to test it as a valid marker of CAD extension.A subgroup of 279 patients (67.4% males) were included in our analysis. Main exclusion criteria were a history of previous percutaneous coronary intervention or surgical revascularisation that prevent an accurate assessment of the SS. Diabetes mellitus, smoking, renal insufficiency, body mass index and a history of CAD and myocardial infarction were all positively and strongly associated with a higher SYNTAX score after adjustment for the non-modifiable biological factors (age and sex). In the multivariate model, age and male sex, along with smoking and renal insufficiency, remain statistical significantly associated with the SYNTAX score.In a selected cohort of revascularisation-naive patients with CAD undergoing coronary angiography, non-modifiable cardiovascular risk factors such as advanced age, male sex, as well as smoking and renal failure were independently associated with CAD complexity assessed by the SYNTAX score. The SYNTAX score may be a valid marker of CAD extension to establish relationships with potential novel biomarkers of coronary atherosclerosis. |
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| ISSN: | 18766250 15685888 |
| DOI: | 10.1007/s12471-017-1005-0 |