Life cycle transcriptome of the malaria mosquito Anopheles gambiae and comparison with the fruitfly Drosophila melanogaster
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| Název: | Life cycle transcriptome of the malaria mosquito Anopheles gambiae and comparison with the fruitfly Drosophila melanogaster |
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| Autoři: | Koutsos, A. C., Blass, Claudia, Meister, Stephan, Schmidt, Sabine, MacCallum, R. M., Soares, M. B., Collins, F. H., Benes, Vladimir, Zdobnov, Evgeny, Kafatos, F. C., Christophides, G. K. |
| Zdroj: | Proceedings of the National Academy of Sciences, Vol. 104, No 27 (2007) pp. 11304-11309 |
| Informace o vydavateli: | Proceedings of the National Academy of Sciences, 2007. |
| Rok vydání: | 2007 |
| Témata: | ddc:616, Male, Life Cycle Stages, Drosophila melanogaster/ genetics/growth & development/metabolism, Transcription, Genetic, Gene Expression Regulation, Developmental, RNA, Messenger/ genetics/metabolism, Insect Vectors, Malaria, 3. Good health, Mice, Drosophila melanogaster, Life Cycle Stages/ genetics/physiology, Anopheles, Malaria/parasitology, Animals, Female, Gene Expression Regulation, Developmental/ genetics, RNA, Messenger, Insect Vectors/genetics, Anopheles gambiae/ genetics/growth & development/metabolism |
| Popis: | The African mosquito Anopheles gambiae is the major vector of human malaria. We report a genome-wide survey of mosquito gene expression profiles clustered temporally into developmental programs and spatially into adult tissue-specific patterns. Global expression analysis shows that genes that belong to related functional categories or that encode the same or functionally linked protein domains are associated with characteristic developmental programs or tissue patterns. Comparative analysis of our data together with data published from Drosophila melanogaster reveal an overall strong and positive correlation of developmental expression between orthologous genes. The degree of correlation varies, depending on association of orthologs with certain developmental programs or functional groups. Interestingly, the similarity of gene expression is not correlated with the coding sequence similarity of orthologs, indicating that expression profiles and coding sequences evolve independently. In addition to providing a comprehensive view of temporal and spatial gene expression during the A. gambiae life cycle, this large-scale comparative transcriptomic analysis has detected important evolutionary features of insect transcriptomes. |
| Druh dokumentu: | Article |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.0703988104 |
| Přístupová URL adresa: | http://www.pnas.org/content/104/27/11304.full.pdf https://pubmed.ncbi.nlm.nih.gov/17563388 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040894/ https://www.pnas.org/content/104/27/11304.short http://www.pnas.org/cgi/doi/10.1073/pnas.0703988104 http://cegg.unige.ch/system/files/agam_devel_PNAS.pdf https://pubag.nal.usda.gov/catalog/2353141 https://pubmed.ncbi.nlm.nih.gov/17563388/ https://archive-ouverte.unige.ch/unige:8837 |
| Přístupové číslo: | edsair.doi.dedup.....74937ca5ae139e9564f127e12ca86a75 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | The African mosquito Anopheles gambiae is the major vector of human malaria. We report a genome-wide survey of mosquito gene expression profiles clustered temporally into developmental programs and spatially into adult tissue-specific patterns. Global expression analysis shows that genes that belong to related functional categories or that encode the same or functionally linked protein domains are associated with characteristic developmental programs or tissue patterns. Comparative analysis of our data together with data published from Drosophila melanogaster reveal an overall strong and positive correlation of developmental expression between orthologous genes. The degree of correlation varies, depending on association of orthologs with certain developmental programs or functional groups. Interestingly, the similarity of gene expression is not correlated with the coding sequence similarity of orthologs, indicating that expression profiles and coding sequences evolve independently. In addition to providing a comprehensive view of temporal and spatial gene expression during the A. gambiae life cycle, this large-scale comparative transcriptomic analysis has detected important evolutionary features of insect transcriptomes. |
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| ISSN: | 10916490 00278424 |
| DOI: | 10.1073/pnas.0703988104 |