Plasma mitochondrial DNA levels are inversely associated with HIV-RNA levels and directly with CD4 counts: potential role as a biomarker of HIV replication: potential role as a biomarker of HIV replication
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| Názov: | Plasma mitochondrial DNA levels are inversely associated with HIV-RNA levels and directly with CD4 counts: potential role as a biomarker of HIV replication: potential role as a biomarker of HIV replication |
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| Autori: | Pernas, Berta, Rego-Pérez, Ignacio, Tabernilla, Andrés, Balboa, Vanesa, Relaño, Sara, Grandal, Marta, Crespo, Manuel, Mena, Alvaro, Castro-Iglesias, Angeles, Blanco, Francisco J, Poveda, Eva |
| Prispievatelia: | Pharmaceutical and Pharmacological Sciences |
| Zdroj: | RUC. Repositorio da Universidade da Coruña instname |
| Informácie o vydavateľovi: | Oxford University Press (OUP), 2017. |
| Rok vydania: | 2017 |
| Predmety: | Adult, Male, 0301 basic medicine, HIV-1/genetics, Virus replication, HIV Infections, Real-Time Polymerase Chain Reaction, Virus Replication, DNA, Mitochondrial, DNA, Mitochondrial/blood, Cohort Studies, Plasma, 03 medical and health sciences, Blood HIV RNA, Virology, Biological makers, Humans, Viral load, RNA, Viral/blood, Viremia, CD4 count determination procedure, 0303 health sciences, HIV, DNA, Middle Aged, Viral Load, HIV infection, Mitochondrial, CD4 Lymphocyte Count, 3. Good health, Spain, HIV Infections/epidemiology, Spain/epidemiology, HIV-1, Cohort studies, RNA, Viral, Female, Biomarkers/blood, Biomarkers |
| Popis: | To evaluate plasma mitochondrial DNA (mtDNA) levels among HIV-infected patients and its potential role as a biomarker of residual viral replication.HIV-infected patients on follow-up at a reference hospital in north-west Spain were selected. DNA was isolated from plasma samples and mtDNA levels were assessed using a quantitative real-time PCR assay. HIV-RNA levels and CD4+ cell counts were evaluated in the same blood samples used for plasma mtDNA quantification. Epidemiological and clinical variables were included for the analysis.A total of 235 HIV-infected patients were included. Mean plasma mtDNA levels were 217 ± 656 copies/μL for naive (31.9%) and 364 ± 939 copies/μL for HIV-infected patients receiving ART and with suppressed viraemia (P = 0.043). Among the latter, mean plasma mtDNA levels were 149 ± 440 copies/μL for those with low-level viraemia (LLV; HIV-RNA 20-200 copies/mL), 265 ± 723 copies/μL for those with detected-not-quantified (DNQ) viraemia (HIV-RNA |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/dkx272 |
| Prístupová URL adresa: | https://academic.oup.com/jac/article-pdf/72/11/3159/21359397/dkx272.pdf https://pubmed.ncbi.nlm.nih.gov/28961892 http://hdl.handle.net/2183/20799 https://europepmc.org/abstract/MED/28961892 https://academic.oup.com/jac/article/72/11/3159/4101634 http://academic.oup.com/jac/article/72/11/3159/4101634/Plasma-mitochondrial-DNA-levels-are-inversely https://www.ncbi.nlm.nih.gov/pubmed/28961892 https://hdl.handle.net/20.500.14017/3c73b92c-170c-4c64-9904-0a3e5128e86b https://doi.org/10.1093/jac/dkx272 https://biblio.vub.ac.be/vubir/(3c73b92c-170c-4c64-9904-0a3e5128e86b).html |
| Prístupové číslo: | edsair.doi.dedup.....733ffc6e74d3cf68091af12561062b1f |
| Databáza: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | To evaluate plasma mitochondrial DNA (mtDNA) levels among HIV-infected patients and its potential role as a biomarker of residual viral replication.HIV-infected patients on follow-up at a reference hospital in north-west Spain were selected. DNA was isolated from plasma samples and mtDNA levels were assessed using a quantitative real-time PCR assay. HIV-RNA levels and CD4+ cell counts were evaluated in the same blood samples used for plasma mtDNA quantification. Epidemiological and clinical variables were included for the analysis.A total of 235 HIV-infected patients were included. Mean plasma mtDNA levels were 217 ± 656 copies/μL for naive (31.9%) and 364 ± 939 copies/μL for HIV-infected patients receiving ART and with suppressed viraemia (P = 0.043). Among the latter, mean plasma mtDNA levels were 149 ± 440 copies/μL for those with low-level viraemia (LLV; HIV-RNA 20-200 copies/mL), 265 ± 723 copies/μL for those with detected-not-quantified (DNQ) viraemia (HIV-RNA |
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| ISSN: | 14602091 03057453 |
| DOI: | 10.1093/jac/dkx272 |