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Low birthweight in patients with type 2 diabetes is associated with elevated risk of cardiovascular events and mortality

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Název: Low birthweight in patients with type 2 diabetes is associated with elevated risk of cardiovascular events and mortality
Autoři: Aleksander L. Hansen, Charlotte Brøns, Leonie M. Engelhard, Mette K. Andersen, Torben Hansen, Jens S. Nielsen, Peter Vestergaard, Kurt Højlund, Niels Jessen, Michael H. Olsen, Henrik T. Sørensen, Reimar W. Thomsen, Allan Vaag
Zdroj: Diabetologia
Hansen, A L, Brøns, C, Engelhard, L M, Andersen, M K, Hansen, T, Nielsen, J S, Vestergaard, P, Højlund, K, Jessen, N, Olsen, M H, Sørensen, H T, Thomsen, R W & Vaag, A 2024, 'Low birthweight in patients with type 2 diabetes is associated with elevated risk of cardiovascular events and mortality', Diabetologia, vol. 67, no. 8, pp. 1616-1629. https://doi.org/10.1007/s00125-024-06170-z
Hansen, A L, Brøns, C, Engelhard, L M, Andersen, M K, Hansen, T, Nielsen, J S, Vestergaard, P, Højlund, K, Jessen, N, Olsen, M H, Sørensen, H T, Thomsen, R W & Vaag, A 2024, ' Low birthweight in patients with type 2 diabetes is associated with elevated risk of cardiovascular events and mortality ', Diabetologia, vol. 67, pp. 1616–1629 . https://doi.org/10.1007/s00125-024-06170-z
Informace o vydavateli: Springer Science and Business Media LLC, 2024.
Rok vydání: 2024
Témata: Male, Adult, Epidemiology, Denmark, Birthweight, Article, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Fetal programming, Diabetes Mellitus, Humans, Birth Weight, Prospective Studies, Mortality, Cardiovascular Diseases/mortality, Aged, Low Birth Weight, Infant, Newborn, Infant, Type 2 diabetes, Middle Aged, Infant, Low Birth Weight, Newborn, Cardiovascular disease, 16. Peace & justice, Type 2/complications, Denmark/epidemiology, 3. Good health, Stroke, Diabetes Mellitus, Type 2, Cardiovascular Diseases, Female, Cohort study
Popis: Aims/hypothesis Low birthweight is a risk factor for type 2 diabetes and CVD. This prospective cohort study investigated whether lower birthweight increases CVD risk after diagnosis of type 2 diabetes. Methods Original midwife records were evaluated for 8417 participants recently diagnosed with type 2 diabetes in the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort. Patients were followed for the first occurrence of a composite CVD endpoint (myocardial infarction, coronary revascularisation, peripheral arterial disease, stroke, unstable angina, heart failure or CVD death), a three-component endpoint comprising major adverse cardiovascular events (MACE), and all-cause mortality. Ten-year risks were estimated using the Aalen–Johansen estimator considering non-CVD death as a competing risk. HRs were determined by Cox regression. Models were controlled for sex, age, calendar year at birth, family history of diabetes and born-at-term status. Results A total of 1187 composite CVD endpoints, 931 MACE, and 1094 deaths occurred during a median follow-up period of 8.5 years. The 10-year standardised composite CVD risk was 19.8% in participants with a birthweight Conclusions/interpretation Having a birthweight Graphical Abstract
Druh dokumentu: Article
Other literature type
Popis souboru: application/pdf
Jazyk: English
ISSN: 1432-0428
0012-186X
DOI: 10.1007/s00125-024-06170-z
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38777869
https://curis.ku.dk/ws/files/403260579/s00125_024_06170_z_2_.pdf
Rights: CC BY
Přístupové číslo: edsair.doi.dedup.....710f550d06a35c943818b9865dbaf799
Databáze: OpenAIRE
Popis
Abstrakt:Aims/hypothesis Low birthweight is a risk factor for type 2 diabetes and CVD. This prospective cohort study investigated whether lower birthweight increases CVD risk after diagnosis of type 2 diabetes. Methods Original midwife records were evaluated for 8417 participants recently diagnosed with type 2 diabetes in the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort. Patients were followed for the first occurrence of a composite CVD endpoint (myocardial infarction, coronary revascularisation, peripheral arterial disease, stroke, unstable angina, heart failure or CVD death), a three-component endpoint comprising major adverse cardiovascular events (MACE), and all-cause mortality. Ten-year risks were estimated using the Aalen–Johansen estimator considering non-CVD death as a competing risk. HRs were determined by Cox regression. Models were controlled for sex, age, calendar year at birth, family history of diabetes and born-at-term status. Results A total of 1187 composite CVD endpoints, 931 MACE, and 1094 deaths occurred during a median follow-up period of 8.5 years. The 10-year standardised composite CVD risk was 19.8% in participants with a birthweight Conclusions/interpretation Having a birthweight Graphical Abstract
ISSN:14320428
0012186X
DOI:10.1007/s00125-024-06170-z